Project Details
Projekt
Mechanisms of CD19+ B cell mediated tissue remodelling as checkpoints in autoimmune- fibrosing disorders such as systemic sclerosis (TP08)
Subject Area
Rheumatology
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 550296805
The project investigates the effect of CD19-CAR-T cell therapy on the molecular skin phenotype in systemic sclerosis, a severe autoimmune disease with high mortality characterised by skin and organ fibrosis. The aim is to deeply phenotype the effects of CD19-CAR-T cell therapy on fibrotic tissue remodelling and vasculopathy using Spatial omics (MERSCOPE) and imaging mass cytometry. Based on these findings, the project will identify mediators that regulate B cell-induced changes in the skin and will identify molecular treatment response patterns as basis to improve personalized treatment strategies in the future.
DFG Programme
Collaborative Research Centres
Applicant Institution
Friedrich-Alexander-Universität Erlangen-Nürnberg
Project Head
Dr. Christina Bergmann
