Deciphering the role of adenylate kinases and microtubule inner proteins in male fertility (B02)

• Subject Area: Cell Biology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 549467913

Flagellar and ciliary motor proteins use ATP as energy source, rendering the maintenance of adenine nucleotide homeostasis essential for sperm motility and male fertility. This project aims to identify genetic variants affecting adenine nucleotide homeostasis in men with impaired sperm motility/motile ciliopathies. Thus, the flagellar adenine nucleotide-homeostasis circuit will be elucidated to facilitate the analysis of pathogenic variants underlying male infertility and to characterise the molecular machinery governing flagellar beating at high resolution. The insights gained will aid the diagnosis, counselling, and treatment of affected men.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1748: Principles of Reproduction – Unravelling the Molecular Mechanisms of Male Infertility
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Heymut Omran