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Zonation-specific endothelial FOXF2 signaling in stroke and small vessel disease (A02)

Subject Area Molecular and Cellular Neurology and Neuropathology
Term since 2026
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 548585053
 
Focusing on the transcription factor FOXF2, this project explores its role in brain endothelial cells and its zonation-specific function in small vessel disease (SVD) and stroke. Using mouse models with endothelial cell-specific FOXF2 deletion, the project studies effects on blood–brain barrier integrity, neurovascular signaling, and astrocyte interactions. It aims to determine how FOXF2 deficiency via its effects on zonation-specific cellular crosstalk affects vascular dysfunction and infarct expansion as a basis for the development of targeted therapeutic interventions for SVD and stroke.
DFG Programme Collaborative Research Centres
 
 

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