Vascular multi-cellular circadian networks as a modulator of stroke progression (A05)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 548585053

This project examines how circadian clocks in endothelial, mural, and neuronal cells modulate stroke progression and outcomes. Using genetic mouse models, single-cell transcriptomics, and clock gene knockouts, the project investigates how circadian disruption—such as light exposure at night—affects infarct size, vascular tone, and blood–brain barrier function. It aims to uncover core circadian mechanisms that determine vulnerability to stroke and evaluates whether restoring circadian integrity can serve as a novel therapeutic approach to improve stroke recovery.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1744: Compartmentalized cellular networks in neurovascular diseases
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professorin Dr. Maria Robles; Dr. Steffen Tiedt