Project Details
Projekt
Cell death and the innate immune response caused by desmoglein dysfunction (B03)
Subject Area
Dermatology
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 547068789
B03 aims to elucidate the mechanisms of desmosomal adhesion loss in pemphigus vulgaris (PV), bullous impetigo (BI), and Darier's disease (DD). Using RNAseq and immunofluorescence of tissue samples, disease-specific and overlapping gene signatures in the three entities will be analyzed. Using CRISPR/Cas9, relevant signaling pathways (necroptosis, apoptosis, pyroptosis, ferroptosis) will be blocked. 3D skin equivalents will be used, among other methods.
DFG Programme
CRC/Transregios
Applicant Institution
Philipps-Universität Marburg
Project Heads
Professor Felix Lauffer, Ph.D.; Professor Dr. Amir Sadegh Yazdi
