Deciphering the role of perivascular inflammation after subarachnoid haemorrhage (B02)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 548585053

This project investigates how perivascular macrophages (PVMs) contribute to early microvascular dysfunction after subarachnoid haemorrhage (SAH). Using in vivo imaging and single-nucleus RNA sequencing, it aims to define how PVMs interact with vascular and parenchymal cells to induce microvasospasm. A special focus is on segment-specific effects (vascular and cellular zonation). The project will identify key molecular pathways and test novel therapeutic strategies to prevent delayed cerebral ischemia caused by PVM-mediated microvascular injury.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1744: Compartmentalized cellular networks in neurovascular diseases
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Nikolaus Plesnila; Professorin Dr. Nicole Terpolilli