Role of lipoproteins in cerebral amyloid angiopathy (C02)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 548585053

This project focuses on the mechanisms how astrocyte-derived lipoproteins, particularly APOE, contribute to amyloid deposition in cerebral amyloid angiopathy (CAA). It explores whether APOE aggregates act as nucleation sites for β-amyloid (Aβ) within the walls of blood vessels. Using transgenic mice, spatial localization techniques, and lipidomic profiling, the project aims to clarify the site and mechanism of APOE aggregation, the contribution of lipid components, and the therapeutic potential of targeting aggregated APOE to slow disease progression in CAA.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1744: Compartmentalized cellular networks in neurovascular diseases
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Mikael Jakob Simons