Dissection of platelet-macrophage-fibroblast interaction in CKD-driven cardiac remodeling (M08*)

• Subject Area: Cardiology, Angiology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

We recently identified a platelet-macrophage-fibroblast interaction as a major driver of maladaptive cardiac remodeling in heart failure. This project aims to molecularly map CKD-induced cardiac remodeling in mice and patients at an unprecedented resolution to dissect aberrant platelet-macrophage-fibroblast crosstalk in maladaptive cardiac remodeling. The insights gained will guide the identification of novel therapeutic targets and the development of targeted interventions to prevent or reverse cardiac dysfunction in CKD patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Dr. Roman Bülow; Dr. Konrad Hoeft