Control and evolution of somite pattern formation during early development (C06)

• Fachliche Zuordnung: Entwicklungsbiologie ; Bioinformatik und Theoretische Biologie
• Förderung: Förderung von 2008 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 13532522

Vertebrate somitogenesis is being studied in a diverse set of animals, and ist understanding has reached a level where theoretical modeling can provide important insights. Here, we focus on an evolutionary transition in the oscillatory Expression pattern of the genes involved in the 'somitogenesis clock*. Such a transition appears to have occurred between Zebrafish and Medaka. We will use theoretical modeling to study the phenotypic variability of the regulatory network controlling somitogenesis, and will perform experiments to characterize the effects of the regulatory evolution in key clock elements.

• DFG-Verfahren: Sonderforschungsbereiche
• Teilprojekt zu: SFB 680: Molekulare Grundlagen evolutionärer Innovationen
• Antragstellende Institution: Universität zu Köln
• Teilprojektleiter: Professor Dr. Ulrich Gerland