Secondary neuroinflammation in the CNS white matter and its modulation by erythropoietin (B06)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2008 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 29837756

The project will investigate the functional integrity of CNS white matter tracts in mouse models of MS when the myelin sheath becomes an inflammatory target of autoaggressive T cells and activated microglia/macrophages. The novelty of this work stems from the recent discovery that oligodendrocytes provide metabolic support to myelinated axons and that the integrity of 'myelinic channels' is required to maintain rapid metabolic fluxes from oligodendrocytes to the axonal compartment.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 43: The Brain as a Target of Inflammatory Processes
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Co-Applicant Institution: Max-Planck-Institut für experimentelle Medizin (aufgelöst)
• Project Heads: Professorin Dr. Hannelore Maria Ehrenreich, from 1/2012 until 1/2012; Professor Klaus-Armin Nave, Ph.D.