The role of immunoproteasomes and the ubiquitin system in inflammatory processes in mouse models of Alzheimer's and Parkinson's disease (B07+)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2008 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 29837756

Immunoproteasomes play an important role in the clearance of damaged proteins to maintain proteostasis during inflammation. The accumulation of damaged proteins, their aggregation, and subsequent cell death along with neuroinflammation represent hallmarks of neurodegeneration. The project aims to investigate the impact of immunoproteasome deficiency on neuroinflammation and disease progression in mouse models of Alzheimer`s and Parkinson`s disease. As immunoproteasome impairment results in autoinflammation along with a striking type I interferon signature, this link will be studied in terms of cytokine profiles, microglia activation, its association with oxidative stress and protein inclusions, as well as neuronal plasticity.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 43: The Brain as a Target of Inflammatory Processes
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Orhan Aktas, until 9/2008; Professor Dr. Frank Heppner; Professor Dr. Peter Michael Kloetzel; Professorin Dr. Elke Beate Krüger