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Eberhard Karls Universität Tübingen
Interfakultäres Institut für Biochemie

Address Auf der Morgenstelle 34
72074 Tübingen
Deutschland

GERiT This institution in GERiT

72074 Tübingen

Projects

Research Grants
- Current projects
- Completed projects
Research Units
- Current projects
  - FOR 2953: Sialic Acid as Regulator in Development and Immunity
    (Spokesperson Mühlenhoff, Martina )
  - Structural Biology of Polysialic Acid Recognition
    (Applicants Stehle, Thilo ; Zocher, Ph.D., Georg )
- Completed projects
  - CNP-induced cGMP signalling in neural differentiation and functional integration
    (Applicant Schmidt, Hannes )
  - Coordination Funds
    (Applicant Feil, Robert )
  - Coordination Funds
    (Applicant Stehle, Thilo )
  - Differential roles of two types of Glycans for cell attachment and entry of Merkel cell polyomavirus
    (Applicant Stehle, Thilo )
  - Dynamic organisation of the localised ASH1 messenger ribonucleoprotein complex in yeast.
    (Applicant Jansen, Ralf-Peter )
  - FOR 2060: cGMP Signalling in Cell Growth and Survival
    (Spokesperson Feil, Robert )
  - FOR 2327: VIROCARB: Glycans Controlling Non-Enveloped Virus Infections
    (Spokesperson Stehle, Thilo )
  - FOR 2333: Macromolecular Complexes in mRNA translocation
    (Spokesperson Niessing, Dierk )
  - Global and local cGMP signals in growth control
    (Applicant Feil, Robert )
  - Mapping the interactomes of localized mRNAs by proximity biotinylation
    (Applicant Jansen, Ralf-Peter )
  - mRNA targeting to the endoplasmic reticulum in budding yeast
    (Applicant Jansen, Ralf-Peter )
  - Receptor Binding and Inhibition of Glycan-binding Polyomaviruses
    (Applicant Stehle, Thilo )
Priority Programmes
- Current projects
  - Correcting a common CRB1 mutation by RNA base editing – towards an unprecedented treatment strategy for retinal degeneration
    (Applicants Achberger, Kevin ; Stafforst, Thorsten )
  - The contribution of cytosolic chaperones to the biogenesis of mitochondrial proteins
    (Applicants Buchner, Johannes ; Rapaport, Doron )
- Completed projects
Independent Junior Research Groups
- Current projects
  - Systems biology analysis of vaccine-induced immunity to infectious diseases in cancer patients
    (Applicant Wimmers, Florian )
- Completed projects
  - Entwicklung und Nutzung chemischer Werkzeuge zur Untersuchung von Histon-Modifikationen und den zugehörigen Enzymen
    (Applicant Schwarzer, Dirk )
Clinical Research Units
- Completed projects
Heisenberg Professorships
- Completed projects
  - Site-directed RNA Editing and Photo-controlled Manipulation of Biochemical Processes
    (Applicant Stafforst, Thorsten )
Heisenberg Grants
- Completed projects
  - Site-directed RNA Editing and Photo-controlled Manipulation of Biochemical Processes
    (Applicant Stafforst, Thorsten )
Collaborative Research Centres
- Current projects
  - Elucidating the native function and signalling components of the cell death executioners Bs3 and Bs4C
    (Project Heads Lahaye, Thomas ; Stehle, Thilo )
- Completed projects
  - A cGMP signaling cascade controlling axonal branching and neuronal circuitry
    (Project Heads Rathjen, Fritz G. ; Schmidt, Hannes )
  - Biochemische Untersuchungen zur MHC II-Prozessierung von Peptid/Proteinantigenen in APC
    (Project Head Kalbacher, Hubert )
  - Biogenesis of outer membrane proteins in evolutionary context
    (Project Head Rapaport, Doron )
  - Coordination of nuclear mRNA maturation and cytoplasmic RNA localization
    (Project Head Jansen, Ralf-Peter )
  - Deletion und Analyse der Funktion der cGMP-abhängigen Proteinkinasen in Mäusen
    (Project Heads Feil, Robert ; Hofmann, Franz )
  - Die Bedeutung der Apoptose und Caspase-vermittelten Freisetzung von Lysophosphatidylcholin in der Atherosklerose
    (Project Head Schulze-Osthoff, Klaus )
  - Die Rolle des kortikalen Zytoskeletts und der Translation vei der mRNA Lokalisierung in Hefe
    (Project Head Jansen, Ralf-Peter )
  - Die Rolle von Todesrezeptor/Liganden-Systemen im entzündlichen Endothel
    (Project Heads Riehemann, Ph.D., Kristina ; Schulze-Osthoff, Klaus )
  - Gezielte Aktivierung des Apoptoseprogramms durch Gentransfer
    (Project Head Schulze-Osthoff, Klaus )
  - H2O2 perception and signal transduction: the specific role of AHK5
    (Project Heads Harter, Klaus ; Stehle, Thilo )
  - Kontrolle der Myosin-Funktion durch Mitglieder der UCS-Proteinfamilie
    (Project Head Jansen, Ralf-Peter )
  - Mechanismen der Apoptose-Induktion und Resistenz gegenüber ionisierender Strahlung
    (Project Heads Jänicke, Reiner U. ; Schulze-Osthoff, Klaus )
  - Mechanismus der Signaltransduktion im endosomalen Membrantransport am Beispiel von Hefe Synaptojanin und interagierenden Proteinen
    (Project Head Singer-Krüger, Birgit )
  - Molecular mechanisms of the biogenesis of mitochondrial outer membrane proteins
    (Project Head Rapaport, Doron )
  - Molecular structure and function of the preprotein translocase of the outer membrane of mitochondria
    (Project Head Rapaport, Doron )
  - Molecular switches between premature senescence and apoptosis in anticancer treatment
    (Project Heads Essmann, Frank ; Schulze-Osthoff, Klaus )
  - Plant receptor kinases as targets for microbial effectors
    (Project Heads Nürnberger, Thorsten ; Stehle, Thilo )
  - Proteases in the MHC class II pathway
    (Project Heads Kalbacher, Hubert ; Melms, Arthur )
  - Regulation of irradiation and chemoresistance by microRNA expression
    (Project Heads Schmitz, Ingo ; Schulze-Osthoff, Klaus )
  - Role of novel unusual inhibitor of NF¦ÊB proteins in inflammation
    (Project Head Schulze-Osthoff, Klaus )
  - Role of the novel IêB protein IêB-æ in the liver
    (Project Heads Jänicke, Reiner U. ; Schulze-Osthoff, Klaus ; Totzke, Gudrun )
  - SFB 773: Understanding and Overcoming Therapy Resistance of Solid Tumours
    (Spokespersons Schulze-Osthoff, Klaus ; Wesselborg, Sebastian )
  - Structural Analysis of Cell Wall Protein Components
    (Project Heads Bertsche, Ute ; Macek, Boris ; Stehle, Thilo )
  - Structural and functional analysis of viral proteins and host receptors
    (Project Head Stehle, Thilo )
  - Structure and Function of Bacterial Cell Wall Proteins
    (Project Head Stehle, Thilo )
  - Struktur und Funktion von Arabidopsis Typ A und Typ B Responseregulatoren
    (Project Head Stehle, Thilo )
  - Transmembrane Signaling in Bacterial Adenylate Cyclases
    (Project Heads Schultz, Joachim E. ; Stehle, Thilo )
Research Fellowships
- Completed projects
  - Die physiologische Funktion der "low molecular weight" - Protein-Tyrosin-Phosphatase: Untersuchungen an der Grenzfläche zwischen Chemie und Biologie
    (Applicant Schwarzer, Dirk )
  - The role of inhibitory interneurons in neurovascular coupling
    (Applicant Thunemann, Martin )
DIP Programme
- Completed projects
  - MitoBalance: Uncovering the mechanisms underlying mitochondrial proteostasis
    (Applicants Rapaport, Doron ; Schuldiner, Ph.D., Maya )
CRC/Transregios
- Completed projects
  - Mechanosensitive cGMP signalling in platelets
    (Project Heads Feil, Robert ; Feil, Susanne )
  - Role of atypical IκB protein IκBζ in HCC formation
    (Project Heads Hailfinger, Stephan ; Schulze-Osthoff, Klaus )
  - Structures of cellular machineries relevant for antibiotic synthesis and action
    (Project Head Stehle, Thilo )
  - X-ray analysis of enzymes and virulence factors of pathogenic staphylococci
    (Project Head Stehle, Thilo )
Major Research Instrumentation
- Completed projects
  - Integrated Confocal/Multiphoton Imaging System
Research Training Groups
- Current projects
  - GRK 2364: MOMbrane: The multifaceted functions and dynamics of the mitochondrial outer membrane (MOM)
    (Spokesperson Rapaport, Doron )
  - GRK 2381: cGMP: From Bedside to Bench
    (Spokesperson Feil, Robert )
  - GRK 2816: Non-canonical G protein signaling pathways: Mechanisms, functions, consequences
    (Spokesperson Nürnberg, Bernd )
- Completed projects
  - GRK 230: Molecular Cell Biology
    (Spokesperson Dobberstein, Bernhard )
  - GRK 686: Mechanisms of Solid Tumor Development and New Concepts of Experimental Therapy
    (Spokesperson Iftner, Thomas )
  - GRK 1089: Protein Interactions and Modifications in Heart
    (Spokesperson Gödecke, Axel )
International Research Training Groups
- Completed projects
  - GRK 1302: The PI3K Pathway in Tumour Growth and Diabetes
    (Spokesperson Nürnberg, Bernd )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2124: Controlling Microbes to Fight Infections (CMFI)
    (Spokespersons Brötz-Oesterhelt, Heike ; Ley, Ruth E. ; Peschel, Andreas )
  - EXC 2180: Image-Guided and Functionally Instructed Tumor Therapies (iFIT)
    (Spokespersons Pichler, Bernd ; Rammensee, Hans-Georg ; Walz, Juliane ; Zender, Lars )

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