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Institution
Johannes Gutenberg-Universität Mainz
Universitätsmedizin
Centrum für Thrombose und Hämostase (CTH)
Address
Langenbeckstraße 1
55131 Mainz
Deutschland
GERiT
This institution in GERiT
55131 Mainz
Projects
Research Grants
Current projects
B-cell acute lymphoblastic leukaemia-derived large oncosomes; where they go and what they do
(Applicant
Minciacchi, Valentina René
)
Disentangling tumor specific regulatory mechanisms of prothrombin gene expression by differential high-content screening in an integrated genetic reporter system
(Applicant
Khan, Ph.D., Essak
)
Regulation of retinoic acid signaling by alternative polyadenylation
(Applicant
Danckwardt, Sven
)
Role of T-cell derived prothrombin in septicemia
(Applicants
Danckwardt, Sven
;
Probst, Hans Christian
)
Completed projects
Anti-oxidative und cytoprotektive Funktionen des Enzyms Paraoxonase-2
(Applicant
Horke, Sven
)
Bedeutung des Adipozytenhormons Leptin für die Plättchenaggegation und Thrombose: Einsicht in die Pathomechanismen und das Thromboserisiko bei Adipositas
(Applicant
Schäfer, Katrin
)
Characterization of the mechanisms of biased coagulation protease signalling: Novel cross talk between protease activated receptor and integrin signalling in glomerular disease.
(Applicant
Thati, Ph.D., Madhusudhan
)
Functional analysis of regulated mRNA 3'end processing in the control of inflammatory processes, innate immunity and tumorigenesis
(Applicant
Danckwardt, Sven
)
Identifizierung und Charakterisierung von Resistenzen ADP-Rezeptor-vermittelter Signalübertragung in humanen Thrombozyten
(Applicant
Großmann, Ralf
)
Integrin alphaIIbß3 mediated Signaling to the Actin Cytoskeleton
(Applicant
Walter, Ulrich
)
Microbiota-induced morphogenetic adaption of the small intestinal architecture
(Applicant
Reinhardt, Christoph Ralf
)
Molecular mechanisms of ANP/cGMP-dependent inhibition of aldosterone production in adrenal gland
(Applicant
Walter, Ulrich
)
Molecular mechanisms of von Willebrand-factor (VWF)-stimulated, NO-independent acitivation of soluble guanylyl cyclase (sGC) in human platelets
(Applicant
Gambaryan, Stephan
)
Molekulargenetik der diabetischen Nephropathie
(Applicant
Lindner, Tom H.
)
New protein kinase A and G-dependent signaling pathways and networks in the regulation of platelet activation
(Applicants
Jurk, Kerstin
;
Zahedi, René P.
)
Regulation of coagulation by the bacteria of the gut microbiota
(Applicant
Reinhardt, Christoph Ralf
)
Rolle von Elastase/PAR-1 im Rahmen der atherosklerotischen Läsionsprogression
(Applicant
Dorweiler, Bernhard
)
The modulation of the hematopoietic system by Paraoxonase-2
(Applicant
Kleinert, Hartmut
)
The role of Paraoxonase 2 (PON2) in resistance of oral squamous cell carcinoma against radio- and chemotherapy
(Applicant
Krüger, Maximilian
)
Priority Programmes
Completed projects
PCF11-dependent regulation of transcriptome 3’end mRNP dynamics during neuronal development
(Applicant
Danckwardt, Sven
)
Independent Junior Research Groups
Current projects
Understanding platelet clearance in health and disease and its feedback to platelet production
(Applicant
Deppermann, Carsten
)
Collaborative Research Centres
Current projects
Coagulation signaling as a modulator for anti-tumor immunity
(Project Heads
Graf, Ph.D., Claudine
;
Ruf, Wolfram
)
Modulating macrophages and platelets in hepatocellular carcinoma and infection
(Project Heads
Deppermann, Carsten
;
Schuppan, Detlef
;
Sprinzl, Martin
)
TF-PAR2 signaling in viral infections
(Project Heads
Beling, Antje
;
Ruf, Wolfram
)
Completed projects
Kardiovaskuläre Effekte nach Ausschaltung des VASP-Gens durch homologe Rekombination im Mäusemodell
(Project Head
Walter, Ulrich
)
Research Fellowships
Completed projects
The role of platelets in neutrophil recruitment and revascularization after sterile injury and infection
(Applicant
Deppermann, Carsten
)
Tissue Factor and PAR2 signaling in the endothelium
(Applicant
Rothmeier, Andrea
)
Major Research Instrumentation
Completed projects
Nicht-invasive intravitale 3D-Kleintierimaging Plattform
Spinning Disk Konfokal Intravitalforschungsmikroskop
CRC/Transregios
Current projects
Coagulation receptors in models of cutaneous inflammation
(Project Head
Ruf, Wolfram
)
Myeloid cell–regulatory T cell crosstalk in thrombus development and resolution
(Project Heads
Bopp, Tobias
;
Ruf, Wolfram
)
Clinical Trials
Current projects
Enhanced recovery and Abbreviated duration of Anticoagulation for thromboprophylaxis after primary hip Arthroplasty: the Enhanced AAA trial
(Applicant
Konstantinides, Stavros
)
Pulmonary Embolism International Thrombolysis Study (PEITHO) Study 3: A reduced dose of intravenous thrombolytic treatment for patients with intermediate high-risk acute pulmonary embolism
(Applicant
Konstantinides, Stavros
)
Research Units
Current projects
FOR 5644: The role of immune cells in the function of the normal and diseased testis and epididymis (‘INFINITE’)
(Spokesperson
Meinhardt, Andreas
)
The connection between the gut microbiome and testicular immune cells: implications for testicular diseases
(Applicants
Bhushan, Sudhanshu
;
Reinhardt, Christoph Ralf
)
Research Training Groups
Current projects
GRK 2859: R-loop Regulation in Robustness and Resilience
(Spokesperson
Luke, Ph.D., Brian
)
DFG Research Centres
Completed projects
Forschungsprofessuren
(Project Head
Lohse, Martin J.
)
Kernzentrum
(Project Head
Lohse, Martin J.
)
Nachwuchsgruppeninstitut
(Project Head
Lohse, Martin J.
)
Öffentlichkeitsarbeit
(Project Head
Lohse, Martin J.
)
Studiengänge
(Project Head
Lohse, Martin J.
)
Zentrale Verwaltung
(Project Head
Lohse, Martin J.
)
Additional Information
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