SFB 1032:
Nanoagents for Spatio-temporal Control of Molecular and Cellular Reactions
Subject Area
Physics
Biology
Chemistry
Term
from 2012 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 201269156
The Collaborative Research Center (CRC) 1032, designs nanoscale biomolecular constructs, i.e. nanoagents, that are capable of controlling functional processes at the molecular scale to extend to interfacing with living cells in a programmable manner. Key design strategies are (i) nucleic acid-based scaffolds, (ii) functionalized membranes and nanotemplated surfaces, and (iii) macromolecular guidance cues in 3D matrices. The CRC structure is outlined in area A, “Spatio-temporal control in nanoscale molecular reaction networks” – focusing on the design principles of nanoagents made from DNA, proteins and lipid membranes – and area B, “Nanosystems controlling cellular dynamics” – where nanoscale agents are used to physically guide or genetically control living cells. The unifying challenge of the CRC is to build artificial constructs at multiple scales in order to control and quantify cellular perturbations, enhance visualization approaches, and more vigorously develop and apply theoretical concepts under highly-controlled confining boundary conditions.
DFG Programme
Collaborative Research Centres
Current projects
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A02 - Sensing and control with nucleic acid hybrid nanoactuators
(Project Head
Simmel, Friedrich
)
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A03 - Programmable pattern formation in systems of communicating subunits
(Project Head
Gerland, Ulrich
)
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A04 - Mechanical breeding of DNA/RNA sequences
(Project Head
Braun, Dieter
)
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A05 - Nano-agents for the manipulation of innate immunity
(Project Head
Carell, Thomas
)
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A06 - DNA assemblies for structural analysis of guest molecules and plasmon-enhanced SERS
(Project Heads
Heuer-Jungemann, Amelie
;
Liedl, Tim
)
-
A07 - DNA scaffolds, rafts and switchable supported lipid membranes studied by x-rays
(Project Heads
Nickel, Bert
;
Rädler, Joachim
)
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A08 - Spatio-temporal control of light-driven plasmonic and photoswitchable nanoagents
(Project Head
Lohmüller, Theobald
)
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A09 - Spatio-temporal positioning of nanoagents by protein self-organization
(Project Head
Schwille, Petra
)
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A10 - Control of organoid structure formation by the mechanical plasticity of collagen networks
(Project Head
Bausch, Andreas
)
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A11 - Nanoimaging of DNA nanoagents interacting with cells
(Project Head
Jungmann, Ralf
)
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A12 - RNA aptamers as sensors for the miR200-family of micro RNAs
(Project Head
Schneider, Sabine
)
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A13 - Membrane Sensors by DNA Nanotech
(Project Head
Tinnefeld, Philip
)
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B01 - Surface designs for the control of cell migration
(Project Heads
Rädler, Joachim
;
Veigel, Claudia
)
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B02 - Formation of Pattern and Shape in Confined Cellular Systems
(Project Head
Frey, Erwin
)
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B03 - Combining advanced fluorescence methods and nanoagents
(Project Head
Lamb, Don C.
)
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B04 - Nucleic acid nanoagents utilizing the intracellular microRNA-200c machinery for switching functions in breast cancer cells
(Project Head
Wagner, Ernst
)
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B08 - Controlling cellular function by structured environments: Artificial angioge-nesis
(Project Head
Zahler, Stefan
)
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B09 - Spatio-temporal control over cell and membrane functions with light-driven nanoagents
(Project Head
Thorn-Seshold, Oliver
)
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B12 - Physical principles of cell migration in confining and structured environments
(Project Head
Broedersz, Chase
)
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MGK - Integrated Research Training Group
(Project Heads
Braun, Dieter
;
Liedl, Tim
;
Ruthardt, Nadia
;
Rädler, Joachim
;
Tinnefeld, Philip
)
-
Z - Central Tasks of the Collaborative Research Centre
(Project Head
Rädler, Joachim
)
Completed projects
