Project Details
Projekt
Deciphering cellular interactions in CNS macrophage niches in mice and humans by spatial proteogenomics (A01)
Subject Area
Molecular and Cellular Neurology and Neuropathology
Immunology
Immunology
Term
since 2017
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024
We will investigate central nervous system (CNS) associated macrophages (CAMs) in CNS border regions in mice and humans through single-cell sequencing and spatial mapping of mRNA and proteins. We will explore the anatomical niches of CAMs, their interactions with adjacent cells as well as with defined stromal cells under homeostatic conditions. Further, we will examine CAMs features and interactions during congenital cytomegalovirus infection (CMV) in mouse and humans. In sum, this project will provide insights into the endogenous immune system at CNS borders during ontogeny, homeostasis and perturbation.
DFG Programme
CRC/Transregios
Subproject of
TRR 167:
Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
Applicant Institution
Technische Universität München (TUM)
Project Heads
Dr. Lukas Amann, since 1/2025; Professor Dr. Marco Prinz
