The role of RNA in synapse physiology and neurodegeneration (B06)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Biophysics
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

This research project investigates the role of RNA in synaptic processes, with a particular focus on non-coding RNAs such as microRNAs (miRNAs) and small nucleolar RNAs (snoRNAs). We will explore the role of synaptically localized miRNAs in regulating synaptic protein levels and plasticity, as well as their contribution to Alzheimer’s disease and Parkinson’s disease. By integrating cutting-edge methodologies and collaborative efforts, this project will provide novel insights, ultimately paving the way for potential therapeutic strategies targeting neurodegenerative diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Professor Dr. André Fischer; Professor Dr. Tiago Fleming Outeiro