Sortilin as a target for fibro-calcific remodeling in CKD (C02)

• Subject Area: Cardiology, Angiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

The increased cardiovascular risk in CKD patients arises from premature vascular and cardiac aging. We identified the intracellular sorting receptor sortilin as a calcification promotor, with post-translational modification of sortilin in CKD further increasing calcification. Also, our findings suggest a function of sortilin in tissue fibrosis. Therefore, this project will use a translational approach to investigate sortilin as a key target for combating fibro-calcific remodeling in the kidney-cardiovascular axis. We will investigate the underlying mechanism of sortilin-mediated fibrosis and identify sortilin inhibitors for reducing vascular calcification and tissue fibrosis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Head: Claudia Göttsch, Ph.D.