Project Details
Projekt
Functional impact of MALT1 protease activation in B cell lymphomagenesis (P07)
Subject Area
Hematology, Oncology
Immunology
Immunology
Term
from 2018 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 360372040
MALT1 acts as a scaffold and a protease in lymphomas addicted to oncogenic activation of BCR signalling. While MALT1 scaffolding activates NF-κB, the contribution of MALT1 protease activity to lymphomagenesis is still unclear. We demonstrated that genetic destruction of TRAF6-MALT1 interaction in mice leads to loss of MALT1 scaffolding, but increased MALT1 protease function. Here, we want to analyse how specific activation of MALT1 protease alone or in combination with NF-κB driver mutations (e.g. oncogenic MYD88) is triggering B cell activation and expansion during different stages of B cell development. We will unravel the molecular consequences of MALT1 protease activation and evaluate options for therapeutic inhibition.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1335:
Aberrant Immune Signals in Cancer
Applicant Institution
Technische Universität München (TUM)
Project Head
Professor Daniel Krappmann, Ph.D.
