Modulating the tumor metastasis propagating and inhibiting effects of tumor associated macrophages via Fc-receptors (B02)

• Subject Area: Hematology, Oncology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 429280966

Tumor-immune cell interactions can modulate tumor establishment and metastasis. Depending on the cytokine environment macrophages and other myeloid cells can fuel inflammation or trigger resolution of inflammation resulting in suppression of (tumor)immunity and tissue repair. In line with this notion, tumor associated macrophages (TAM) can support or limit tumor growth and metastasis depending on the organ environment. The project aims at (1) identifying organ specific roles of bone marrow derived versus tissue resident macrophages in modulating tumor growth and early metastatic colonisation, (2) at characterizing and alter the phenotype of TAM subpopulations present in tumors growing in different organ environments, and (3) at studying the role of myeloid effector cells in supporting or limiting human primary melanoma and early metastatic melanoma colonisation and growth in humanized mice in vivo.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 305: Striking a moving target: From mechanisms of metastatic colonization to novel systemic therapies
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Falk Nimmerjahn