Project Details
Projekt
One CAR – multiple antigens: Universal CAR-T cells that are chemically programmed to recognize tumors (A02)
Subject Area
Hematology, Oncology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 452881907
In this project, we will use a chemically programmable CAR (cpCAR) that can be redirected to target multiple antigens simultaneously or sequentially to address heterogeneous target cell populations and to prevent antigen loss as a major obstacle to effective CAR-T cell therapy. We will perform careful analysis of target cell engagement, cpCAR signaling and functional output in comparison to ‘conventional’ scFv-based CARs in the context of hematologic and solid tumors. Further, we will use the cpCAR as a co-receptor to augment co-stimulatory signaling and in logic gates to enhance selectivity for target cells.
DFG Programme
CRC/Transregios
Applicant Institution
Technische Universität München (TUM)
Project Head
Professor Dr. Michael Hudecek
