Project Details
Projekt
Dissection and correction of human regulatory T cell dysfunctions by CRISPR engineering (C04)
Subject Area
Immunology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 452881907
Children with monogenic IBD (mIBD) often suffer from severe, therapy-refractory disease. The project will evaluate the potential of genetically engineered antigen-specific Tregs with chimeric antigen receptors (CAR Tregs) for the treatment of mIBD. Gut-specific CAR Tregs overexpressing key immunoregulatory cytokines (e.g., IL-10, TGF-β1) and/or the master transcription factor Fopx3 will be engineered by gene editing and/or modulation via microbial metabolites to enhance their potency for targeted treatment of mIBD or autoimmune enteropathies caused by Foxp3, IL-10 and TGF-β1 deficiencies.
DFG Programme
CRC/Transregios
Applicant Institution
Technische Universität München
Project Heads
Professor Dr. Daniel Kotlarz; Professor Dr. Maik Luu, since 1/2026; Professorin Dr. Kathrin Schumann, Ph.D., until 12/2025
