SPP 1086:  Genetic and Molecular Analysis of Basement Membranes and Basement Membrane Anchorage

• Subject Area: Medicine
• Term: from 2000 to 2006
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5470026

No abstract available

• DFG Programme: Priority Programmes
• International Connection: Italy

Projects

• Analysis of Laminin - alpha7beta1 Integrin Interactions: Ligand specificity and Binding sites (Applicant von der Mark, Ph.D., Klaus )
• Bedeutung der mikrofibrillären Proteine Fibrillin-1, Emilin und Kollagen VI in der Verankerung der Basalmembran normaler und erkrankter Glomeruli (Role of microfibrillar proteins fibrillin-1, emilin and collagen type VI in basement membrane anchorage of normal and diseased glomeruli) (Applicant Sterzel, Ralf Bernd )
• Bedeutung des "kidney injury molecule-1" für die Zell-Matrix-Wechselwirkung von renalen tubulären Epithelzellen nach ischämischer Nierenschädigung (Role of "kidney injury molecule-1" in cell-matrix interaction of renal tubular epithelial cells after ischemic injury to the kidney) (Applicant Schulze-Lohoff, Eckhard )
• Biochemical and functional analysis of laminin isoforms, laminin-5, -6 and -7 (Applicant Sasaki, Takako )
• Characterization and functional analysis of collagen XXII (Applicant Bruckner-Tuderman, Leena Kaarina )
• Collagen XXII: A novel collagen of basement membranes and other tissue junctions (Applicant Koch, Manuel )
• Die Rolle von Lamininen für Bildung und "Remodeling" von epithelialen Basalmembranen (The role of laminins in the formation and the remodeling of epithelial basement membranes) (Applicant Aumailley, Monique )
• Die Rolle von Zell-Zell- und Zell-Matrix-Interaktionen bei der Synthese und Aktivierung von MMP-2 und MMP-9 in epidermalen Tumorzellen in vitro und in vivo (Applicant Nischt, Roswitha )
• Establishment and maintenance of the SPP1086 homepage. Exchange of methods between SPP groups (Applicant Paulsson, Mats )
• Functional analysis of Discoidin domain receptors during kidney development and progressive renal disease (Applicant Vogel, Wolfgang )
• Functional characterization of Laminin 10 (Applicant Sorokin, Lydia )
• Functions of laminin isoforms during hematopoietic stem cell development (Applicant Klein, Gerd )
• Funktion des Laminin-bindenden Integrins alpha7beta1 während der Embryonalentwicklung (Functional analysis of the Laminin-binding Integrin alpha7beta1 during Embryonic Development) (Applicant Mayer, Ulrike )
• Funktionelle Charakterisierung der alpha7beta1 Integrin bindenden Proteine (Applicant Wixler, Ph.D., Viktor )
• Genetic analysis of nidogens during embryonic development in mice, in particular in bone development (Applicant Bader, Bernhard )
• Identification of alpha 1 beta 1 and alpha 2 beta 2 integrin recognition motifs within basement membrane ligands using phage display library screening, and their physiological effects on cells (Applicant Eble, Johannes Andreas )
• In vivo contributions of collagen IV for structure, stability and function of basement membranes (Applicant von der Mark, Ph.D., Klaus )
• Molecular and genetic analysis of domains mediating laminin self interactions (Applicant Paulsson, Mats )
• Molecular and genetic analysis of domains mediating laminin self-interactions (Applicant Sinz, Andrea )
• Molecular interactions between microfibrils and basement membranes (Applicant Reinhardt, Dieter )
• Molecular interactions between microfibrils and basement membranes (Applicant Schlötzer-Schrehardt, Ursula )
• Molekulare Mechanismen der chronischen Glomerulonephritis - Funktion eines neuen kleinen Heparansulfat-Proteoglycans in der glomerulären Basalmembran (Molecular basis of renal disease - function of a novel small heparan sulfate proteoglycan in the glomerular basement membrane) (Applicant Floege, Jürgen )
• Regulation der Basalmembranbildung in organotypischen Kokulturen von Haut-Keratinozyten (inklusive Zell-Linien) und Fibroblasten (Applicant Breitkreutz, Dirk )
• Role of beta1-integrins for G protein-coupled signaling cascades (Applicant Bloch, Wilhelm )
• Role of integrins, extracellular matrix ligands and matrix metalloproteinase-13 in an in vitro periodontitis model (Applicant Tomakidi, Pascal )
• Rolle von beta1-Integrinen für die Lokalisation und Funktion membran-assoziierter Signalmoleküle und Ionenkanäle (Role of beta1-integrins for localization and function of membrane-associated signaling molecules and ion channels) (Applicant Addicks, Klaus )
• Shedding of epidermal transmembrane proteins (Applicant Bruckner-Tuderman, Leena Kaarina )
• Significance of the extracellular cleavage of BP180/type XVII collagen for skin biology and disease (Applicant Hirako, Yoshiaki )
• Structure and function of SMOC-1 and SMOC-2, two novel calcium-binding proteins associated with basement membranes (Applicant Hartmann, Ursula )
• Struktur und Funktion von LG-Modulen des Laminins (Structure and function of LG modules of laminins) (Applicant Timpl, Rupert )
• Struktur und Funktion von SMOC-1 und SMOC-2, zwei neuen modulären, calciumbindenden und Basalmembran-assoziierten Proteinen (Structure and funcation of SMOC-1 und SMOC-2, two novel modular calcium-binding proteins associated with basement membranes) (Applicant Maurer, Patrik )
• Strukturelle und funktionelle Untersuchungen von Basalmembranen und ihren Rezeptoren in der Pathogenese hereditärer Muskelerkrankungen (Applicant Straub, Volker Wilhelm )
• The role of heparansulfate proteoglycan agrin at the retina - basal lamina interface in the developing CNS (Applicant Kröger, Stephan )
• Zielgerichtete Transduktion aktivierter Endothelzellen mit adenoviralen Vektoren großer DNA-Kapazität und Expression von angiostatischen Faktoren und Matrix Metalloproteinase (MMP) Inhibitoren (Targeted transduction of activated endothelial cells with high-capacity adenoviral vectors and expression of angios (Applicant Kochanek, Stefan )

• Spokesperson: Professor Dr. Mats Paulsson