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Universitätsklinikum Freiburg
Department Innere Medizin
Klinik für Innere Medizin II - Gastroenterologie,
Hepatologie, Endokrinologie u Infektiologie

Address Hugstetter Straße 55
79106 Freiburg
Deutschland

GERiT This institution in GERiT

79106 Freiburg

Projects

Research Grants
- Current projects
- Completed projects
Priority Programmes
- Completed projects
  - Native display of Borrelia antigens on the surface of hepatitis B virus capsids: Improved prophylactic and potential therapeutic vaccines against Lyme disease
    (Applicant Nassal, Michael )
Independent Junior Research Groups
- Completed projects
  - Molekulare Voraussetzungen für die Entwicklung immundominanter und protektiver Virus-spezifischer CD8+ T-Zellantworten
    (Applicant Neumann-Haefelin, Christoph )
  - T-cell response to hepatitis B and C
    (Applicant Thimme, Robert )
Heisenberg Professorships
- Completed projects
  - Immunbiologie der Hepatitis B und C Virus-Infektion und des hepatozellulären Karzinoms
    (Applicant Thimme, Robert )
Research Units
- Current projects
  - FOR 5560: Crosstalk between B cell metabolism and signaling
    (Spokesperson Jellusova, Julia )
  - Metabolic regulation of plasma cell function and antibody glycosylation
    (Applicants Bengsch, Ph.D., Bertram ; Voll, Reinhard )
- Completed projects
Heisenberg Fellowships
- Current projects
  - Regulation of T cell exhaustion in chronic hepatitis B infection and hepatocellular carcinoma
    (Applicant Bengsch, Ph.D., Bertram )
- Completed projects
  - Mechanistic analysis of Vascular Endothelial Growth Factor (VEGF) Internal Ribosomal Entry Site (IRES)-mediated translation in tumorigenesis
    (Applicant Thoma, Christian )
Scientific Networks
- Current projects
  - Initiation of the Clinical Research Network 'German Study Network in Infectious Diseases' (DEutsches STudiennetzwerk INfektiologie, DESTINi)
    (Applicant Rieg, Siegbert )
Heisenberg Grants
- Current projects
  - Mechanisms of human CD8+ T cell heterogeneity and maintenance in COVID19 vaccination, viral hepatitis and liver cancer
    (Applicant Hofmann, Maike )
  - Regulation of T cell exhaustion in chronic hepatitis B virus infection and hepatocellular carcinoma
    (Applicant Bengsch, Ph.D., Bertram )
Research Fellowships
- Completed projects
Collaborative Research Centres
- Current projects
  - Bi-directional communication between intraepithelial lymphocytes and epithelial cells to maintain intestinal barrier integrity
    (Project Heads Sagar, Sagar ; Tanriver, Yakup )
  - Bioinformatics Core
    (Project Heads Börries, Melanie ; Sagar, Sagar )
  - Clinical integration of microbiome research
    (Project Heads Gessner, Ph.D., André ; Middelhoff, Moritz ; Quante, Michael ; Steiger, Katja )
  - Diverging mechanisms of antigen-specific CD8+ T cell dysfunction result in protective versus pathogenic responses in chronic hepatitis B virus infection
    (Project Heads Hofmann, Maike ; Thimme, Robert )
  - Immunopathology Unit
    (Project Heads Bengsch, Ph.D., Bertram ; Schell, Ph.D., Christoph B. )
  - Mechanisms of hepatitis E virus persistence and immunopathology in immunocompromised patients
    (Project Head Neumann-Haefelin, Christoph )
  - Pathogenic instruction of CD8 T cell differentiation in Crohn’s disease
    (Project Head Bengsch, Ph.D., Bertram )
  - Targeting the pro-oncogenic ER-stress mediator ATF6 to reset the immunosuppressive tissue-microenvironment in liver cancer
    (Project Heads Heikenwälder, Mathias ; Hofmann, Maike )
  - Understanding the crosstalk between juvenile myelomonocytic leukaemia (JMML) and immune cells
    (Project Heads Bengsch, Ph.D., Bertram ; Erlacher, Miriam )
- Completed projects
  - Alpha-Fetoprotein spezifische Immuntherapie des hepatozellulären Karzinoms
    (Project Heads Blum, Hubert E. ; Geißler, Michael ; Mohr, Leonhard )
  - CXCR4-imaging in esophageal cancer - diagnosis and prognosis
    (Project Heads Quante, Michael ; Schottelius, Margret ; Wester, Hans-Jürgen )
  - Identification and functional analysis of regulatory T cells during chronic HCV infection
    (Project Head Thimme, Robert )
Major Research Instrumentation
- Completed projects
  - Durchflusszytometer mit 5 Lasern
  - Massenspektrometer-gekoppeltes Zytometer mit Imagingfähigkeit
CRC/Transregios
- Current projects
Further Instrumentation Related Funding
- Current projects
  - The German Mass Cytometry Alliance
    (Applicants Baumgart, Sabine ; Bengsch, Ph.D., Bertram ; Kunkel, Désirée ; Mei, Henrik ; Warth, Sarah )
Research Training Groups
- Completed projects
  - GRK 300: Pathogenic Microorganisms: Molecular Mechanisms and Genomic Approaches
    (Spokesperson Clayton, Christine Elizabeth )
Clinical Trials
- Completed projects
  - Covered transjugular intrahepatic portosystemic stent shunt versus optimezed medical treatment for the secondary prevention of variceal bleeding in cirrhosis
    (Applicant Sauerbruch, Tilman )
Graduate Schools
- Completed projects
  - GSC 4: Molecular Cell Research in Biology and Medicine (MOBILMED)
    (Spokesperson Borner, Christoph )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2189: CIBSS - Centre for Integrative Biological Signalling Studies
    (Spokespersons Driever, Wolfgang ; Hunte, Carola ; Kleine-Vehn, Jürgen ; Weber, Wilfried )

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