Project Details
Projekt
SFB 688: Mechanisms and Imaging of Cell-Cell-Interactions in the Cardiovascular System
Subject Area
Medicine
Biology
Biology
Term
from 2006 to 2017
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 14085162
In this Collaborative Research Centre, scientists and clinicians from four faculties and eleven institutes/clinics of the University of Würzburg investigate:
(1) basic function and mechanisms of cardiovascular cell-cell interactions;
(2) molecular and functional imaging of the cardiovascular system and its cell-cell-interactions.
This collaboratory project covers research disciplines such as physics, chemistry, biochemistry, cell biology, theoretical and clinical medicine, including cardiology, neurology and haemostaseology. Cell-cell-interactions in the cardiovascular system are essential for the circulatory blood supply and organ perfusion. They are part of inflammation, healing and a variety of adaptation processes.
Pathological cell-cell-interactions are also involved in the pathogenesis of numerous diseases and present important targets for novel diagnostic and therapeutic concepts. Such dysfunctions of these dynamically and temporarily regulated blood and vessel wall cells represent the foundations of the acute coronary syndrome and follow-up complications and diseases. Blood leukocyte transmigration and invasion is central to the pathology of cardiac and cerebral ischemia/reperfusion and their resulting injuries. The function and dysfunction of cell-cell interactions will therefore be investigated, aiming to recognise and prevent major cardiovascular diseases at an early onset. Many projects of the Collaborative Research Centre also collaborate on the phenotypical characterisation of murine disease models and address the following questions:
(1) analysis of platelets, platelet-/cell wall interactions and endothelial barrier functions covering molecular approaches to clinical application. Modern methods of biochemistry/cell biology, functional proteomics and bioinformatics as well as murine and human physiology, pathophysiology and haemostaseology, experimental and clinical cardiology and neurology are applied;
(2) analysis of locally generated murine disease models with respect to pathological cell-cell-interactions, and their cardiovascular, cerebrovascular and haemostaseological phenotypes;
(3) developing novel in vivo imaging techniques for an early diagnosis of pathological cell-cell-interactions of vessels, relevant for murine disease models and at a later stage, applications on humans.
In the first year of the current funding period (2006) the Collaborative Research Centre published 29 original articles and six reviews (see homepage www.sfb688.de).
(1) basic function and mechanisms of cardiovascular cell-cell interactions;
(2) molecular and functional imaging of the cardiovascular system and its cell-cell-interactions.
This collaboratory project covers research disciplines such as physics, chemistry, biochemistry, cell biology, theoretical and clinical medicine, including cardiology, neurology and haemostaseology. Cell-cell-interactions in the cardiovascular system are essential for the circulatory blood supply and organ perfusion. They are part of inflammation, healing and a variety of adaptation processes.
Pathological cell-cell-interactions are also involved in the pathogenesis of numerous diseases and present important targets for novel diagnostic and therapeutic concepts. Such dysfunctions of these dynamically and temporarily regulated blood and vessel wall cells represent the foundations of the acute coronary syndrome and follow-up complications and diseases. Blood leukocyte transmigration and invasion is central to the pathology of cardiac and cerebral ischemia/reperfusion and their resulting injuries. The function and dysfunction of cell-cell interactions will therefore be investigated, aiming to recognise and prevent major cardiovascular diseases at an early onset. Many projects of the Collaborative Research Centre also collaborate on the phenotypical characterisation of murine disease models and address the following questions:
(1) analysis of platelets, platelet-/cell wall interactions and endothelial barrier functions covering molecular approaches to clinical application. Modern methods of biochemistry/cell biology, functional proteomics and bioinformatics as well as murine and human physiology, pathophysiology and haemostaseology, experimental and clinical cardiology and neurology are applied;
(2) analysis of locally generated murine disease models with respect to pathological cell-cell-interactions, and their cardiovascular, cerebrovascular and haemostaseological phenotypes;
(3) developing novel in vivo imaging techniques for an early diagnosis of pathological cell-cell-interactions of vessels, relevant for murine disease models and at a later stage, applications on humans.
In the first year of the current funding period (2006) the Collaborative Research Centre published 29 original articles and six reviews (see homepage www.sfb688.de).
DFG Programme
Collaborative Research Centres
International Connection
Canada
Completed projects
- A01 - Studies on the cellular regulation of platelet adhesion receptors in hemostasis and thrombosis (Project Head Nieswandt, Bernhard )
- A02 - Comparative modeling of signaling in platelets (Project Head Dandekar, Thomas )
- A03 - Pathologische Aktivierung des Kontaktphasesystems in vivo - Schnittstelle zwischen Hämostase und vaskulärer Entzündu (Project Heads Nieswandt, Bernhard ; Renné, Thomas )
- A04 - Regulation of the endothelial barrier by Rho GTPases in vivo and in vitro (Project Head Waschke, Jens )
- A05 - Molekulare Mechanismen der Steroid-vermittelten Regulation der Permeabili-tät der Blut-Hirn-Schranke (Project Head Förster, Carola )
- A06 - Molekulare Mechanismen und funktionelle Auswirkungen der Immunzellmigration durch zerebrale Endothelzellen (Project Head Rieckmann, Peter )
- A07 - Vascular effects of the natriuretic peptides ANP, BNP and CNP (Project Head Kuhn, Michaela )
- A10 - Inflammation and cardiac damage - role of CD4+ T cells after myocardial infarct (Project Heads Ertl, Georg ; Frantz, Stefan ; Hofmann, Ulrich ; Kerkau, Thomas )
- A11 - Vascular functions of the cytoskeletal regulatory phosphatases chronophin and AUM (Project Head Gohla, Antje )
- A12 - Th17 cells in the pathogenesis of atherosclerosis (Project Head Zernecke-Madsen, Alma )
- A13 - Kallikrein/Kinin-System mediated cell/cell-interactions at the blood-brain-barrier during cerebral ischemia (Project Head Kleinschnitz, Christoph )
- A16 - Function of the Hey and Hes bHLH factors in the vascular system (Project Head Gessler, Manfred )
- A17 - New pathways of G protein mediated ERK1/2 activation in cardiovascular cells (Project Head Lorenz, Kristina )
- A18 - The role of platelet Mg2+ channels in thrombosis and hemostasis (Project Head Braun, Ph.D., Attila Laszlo )
- A19 - CEACAM1-isoprostane-interaction in initiation and progression of atherosclerosis (Project Head Ergün, Süleyman )
- A20 - Relevance of IL-6 receptor gp130 endocytosis to control inflammatory processes in the cardiovascular system (Project Heads Ertl, Georg ; Frantz, Stefan ; Hermanns, Heike M. )
- A21 - Role of matrix proteins and their receptors during thrombopoiesis (Project Head Schulze, Harald )
- A22 - Gamma-Delta-T cells in the pathogenesis of atherosclerosis (Project Head Zernecke-Madsen, Alma )
- B01 - Cell-cell interactions in the pathogenesis of cerebral ischemia: mechanisms of thrombus formation and MR imaging (Project Heads Nieswandt, Bernhard ; Stoll, Guido )
- B02 - MR-Bildgebung der myokardialen Wundheilung (Project Heads Bauer, Wolfgang Rudolf ; Waller, Christiane )
- B03 - Entwicklung und Einsatz intelligenter MR-Kontrastmittel und Methoden zur molekularen in vivo Bildgebung (Project Heads Jakob, Peter M. ; Schenk, Wolfdieter A. )
- B04 - High resolution MR imaging for non invasive characterization of vessel structure and endothelial function (Project Heads Bauer, Wolfgang Rudolf ; Rommel, Eberhard )
- B05 - Magnetic field correlation imaging for characterization and quantification of the arrangement of cells and microvessels (Project Head Bauer, Wolfgang Rudolf )
- B06 - In vivo Detektion der Rezeptor-Signaltransduktion mittels FRET Mikroskopie (Project Heads Bünemann, Moritz ; Lohse, Martin J. )
- B07 - Spatiotemporal analyses of cell-cell interactions in the ischemic brain using two-photon and light sheet microscopy (Project Heads Heinze, Katrin G. ; Stegner, David ; Stoll, Guido )
- B08 - Intracellular cAMP- and cGMP-compartments in cell-cell communication in the cardiovascular system (Project Head Lohse, Martin J. )
- N01 - Effektoren der endothelialen Permeabilität (Project Head Renné, Thomas )
- Z01 - Administration (Project Head Nieswandt, Bernhard )
- Z02 - Integrative vascular functional analysis using imaging (Project Heads Ertl, Georg ; Jakob, Peter M. ; Samnick, Samuel )
Applicant Institution
Julius-Maximilians-Universität Würzburg
Spokesperson
Professor Dr. Bernhard Nieswandt
