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Institution
Rheinische Friedrich-Wilhelms-Universität Bonn
Medizinische Fakultät
Institut für Biochemie und Molekularbiologie
Address
Nußallee 11
53115 Bonn
Deutschland
GERiT
This institution in GERiT
53115 Bonn
Projects
Priority Programmes
Current projects
Coordination Funds
(Applicant
Becker, Thomas
)
Nuclear quality control of non-imported mitochondrial precursor proteins
(Applicants
den Brave, Fabian
;
Mogk, Axel
)
SPP 2453: Integration of mitochondria into the cellular proteostasis network
(Spokesperson
Becker, Thomas
)
The role of J-domain proteins in quality control of mitochondrial protein import
(Applicants
Becker, Thomas
;
Kirstein, Janine
)
The role of lysosomal protein degradation in mitochondrial membrane stress responses
(Applicants
van der Laan, Martin
;
Winter, Dominic
)
Completed projects
Biochemical and structural characterization of mammalian deiodinases as key regulators of thyroid hormone metabolism
(Applicants
Schweizer, Ulrich
;
Steegborn, Clemens
)
Cell type-specific inactivation of Mct8 in brain cells: Gene expression, metabolism, morphology
(Applicant
Wirth, Eva K.
)
Charakterisierung von Interaktionspartnern der Collapsin-Response-Mediator-Proteine
(Applicant
Kappler, Joachim
)
Oral thyroxine resistance revisited - how thyroxine transpasses the gut-blood barrier
(Applicants
Führer-Sakel, Dagmar
;
Schweizer, Ulrich
)
Physiological effects of altered Se transport and Se tissue distribution in selenoprotein P knock out mice - studies on the impact of gender on the phenotype
(Applicant
Schomburg, Lutz
)
Structure and function of the thyroid hormone transporter MCT8
(Applicant
Schweizer, Ulrich
)
The effect on translational efficiency of the i6A37 modification in cytoplasmic and mitochondrial tRNAs: Mitochondrial and selenoproteins.
(Applicant
Schweizer, Ulrich
)
The functionals role of AAA+ proteases as central components of the mitochondrial protein quality control network under normal and stress conditions
(Applicant
Voos, Wolfgang
)
Research Grants
Current projects
Investigation of sodium phenylbutyrate (NaPB) as a chemical chaperone for the treatment of Mct8-deficient mouse models
(Applicants
Braun, Doreen
;
Schweizer, Ulrich
)
SUMO-dependent control of mitochondrial protein biogenesis
(Applicant
den Brave, Fabian
)
The role of Por1 and its partner protein Om14 in mitochondrial protein import
(Applicant
Becker, Thomas
)
Completed projects
Crosstalk between mitochondrial and lipid biogenesis
(Applicant
Becker, Thomas
)
Investigation into the role of Secisbp2 in re-coding of UGA codons in selenoproteins by global ribosomal footprinting
(Applicant
Schweizer, Ulrich
)
Metabolism and function of N-acetylaspartate, N-acetylaspartylglutamate and related metabolites
(Applicant
Eckhardt, Matthias
)
Molecular and cellular mechanisms to protect against the accumulation of protein aggregates in mitochondria
(Applicant
Voos, Wolfgang
)
Posttranslationale Modifikationen N-gebundener Oligosaccharidseitenketten lysosomaler Arylsulfatasen
(Applicant
Gieselmann, Volkmar
)
Sex-specific selenoprotein expression and selenium metabolism
(Applicant
Schomburg, Lutz
)
Sexually dimorphic generation of estradiol from estrone sulfate and other hormonal molecules from adrenal precursors in the life cycle of normal and abnormal human hair growth.
(Applicant
Schweizer, Ulrich
)
Transgene Mausmodelle zur Untersuchung der Funktion der Polysialinsäure für die neuronale Entwicklung und Myelinisierung
(Applicant
Eckhardt, Matthias
)
Untersuchungen zur lokalen Synthese und Wirkung biologisch aktiver Metaboliten im menschlichen Knochen aus Estradiol sowie Dehydroepiandrosteronsulfat
(Applicant
Schweikert, Hans-Udo
)
Untersuchungen zur lokalen Synthese und Wirkung biologisch aktiver Metaboliten in menschlichen Haarwurzeln aus Estradiol sowie Dehydroepiandrosteronsulfat
(Applicant
Schweikert, Hans-Udo
)
Research Units
Current projects
FOR 2625: Mechanisms of Lysosomal Homeostasis
(Spokesperson
Braulke, Thomas
)
Lysosomal gene transcription and protein expression
(Applicants
Braulke, Thomas
;
Winter, Dominic
)
Completed projects
Quantitative determination of the effect of transcription factors TFEB and TFE3 on the expression of lysosomal proteins
(Applicants
Gieselmann, Volkmar
;
Winter, Dominic
)
Heisenberg Grants
Current projects
The Dynamic Proteome of the Lysosome
(Applicant
Winter, Dominic
)
Collaborative Research Centres
Current projects
Quality control at the protein entry gate of mitochondria
(Project Head
Becker, Thomas
)
Completed projects
Aktives Zentrum, Aufbau und Membrantopologie des Oligosaccharyltransferase-Komplexes aus Schweineleber
(Project Head
Bause, Ernst
)
Charakterisierung und Lokalisierung GPI-spaltender Enzyme in Trypanosoma brucei brucei
(Project Head
Schuler, Frank
)
Die Funktion molekularer Chaperone und ihrer Interaktionspartner beim Import mitochondrialer Vorstufenproteine
(Project Head
Voos, Wolfgang
)
Enzymologie und Molekularbiologie von processing-Glykosidasen
(Project Heads
Bause, Ernst
;
Völker, Christof
)
Functional consequences of altered sphingolipid metabolism in myelinating cells
(Project Head
Eckhardt, Matthias
)
Molekulare Mechanismen der Pathogenese der Metachromatischen Leukodystrophie
(Project Head
Gieselmann, Volkmar
)
Neuronal T3 transport and interneuron development
(Project Heads
Grüters-Kieslich, Annette
;
Krude, Heiko
;
Schweizer, Ulrich
)
Protein and lipid analysis by mass spectrometry and lipid metabolic tracing
(Project Heads
Dörmann, Peter
;
Gieselmann, Volkmar
;
Thiele, Christoph
)
Rolle von mitochondrialen Hsp70 und Partnerproteinen beim Proteinimport
(Project Heads
Meisinger, Chris
;
Voos, Wolfgang
)
Struktur- und Konformationsanalyse der Glycokonjugate
(Project Head
Klein, Roger A.
)
The protein sorting and assembly maschineries of the mitochondrial outer membrane
(Project Heads
Becker, Thomas
;
Pfanner, Nikolaus
)
Untersuchungen zur JBiosynthese normaler und mutanter Arylsulfatase
(Project Head
Gieselmann, Volkmar
)
Untersuchungen zu Veränderungen der Signaltransduktion bei der Metachromatischen Leukodystrophie
(Project Head
Gieselmann, Volkmar
)
Untersuchungen zu veränderungen der Signaltransduktion und Genexpression bei der Metachromatischen Leukodystrophie
(Project Head
Gieselmann, Volkmar
)
Major Research Instrumentation
Completed projects
ESI/MALDI Massenspektrometer
HPLC-gekoppeltes Elektrospray-Tandemmassenspektrometer
Clinical Research Units
Completed projects
Cellular thyroid hormone signalling mechanisms during weight maintenance
(Applicant
Köhrle, Josef
)
Novel physiological thyroid hormone metabolites as potent modulators of energy expenditure and body weight
(Applicant
Köhrle, Josef
)
Additional Information
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