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Institution
Universität Duisburg-Essen
Campus Essen
Zentrum für Medizinische Biotechnologie (ZMB)
Address
Universitätsstraße
45141 Essen
Deutschland
GERiT
This institution in GERiT
45141 Essen
Projects
Research Grants
Current projects
Implications of the serine protease HTRA1 in Light Chain Amyloidosis
(Applicants
Carpinteiro, Alexander
;
Ehrmann, Michael
)
Multivalency in DNA-confined spaces
(Applicant
Saccà, Barbara
)
Replication origin firing regulation to ensure genome stability in metazoan cells
(Applicant
Boos, Dominik
)
Completed projects
A semisynthetic protease DNA-nanomachine
(Applicant
Saccà, Barbara
)
Callyaerins as lead structures and chemical probes for antitubercular drug discovery
(Applicants
Kaiser, Markus
;
Kalscheuer, Rainer
)
Cellular factors implicated in amyloid fibril homeostasis
(Applicant
Ehrmann, Michael
)
Characterisation of the human serine protease HTrA1
(Applicant
Ehrmann, Michael
)
Exploration of carbohydrate metabolism in hyperthermophilic archaea: novel approaches, enzymes and metabolic pathways
(Applicants
Kaiser, Markus
;
Siebers, Bettina
)
Extracytoplasmic protein folding stress signalling as a target for the development of novel antibiotics
(Applicants
Ehrmann, Michael
;
Kaiser, Markus
)
Genome-wide activity-based profiling of Arabidopsis proteomes
(Applicants
van der Hoorn, Renier A.L.
;
Kaiser, Markus
;
Schmidt, Jürgen
)
Implications of the human serine protease HtrA1 in Alzheimer's disease
(Applicant
Ehrmann, Michael
)
Reconfigurable DNA-nanochambers as dynamic compartmentalization systems
(Applicant
Saccà, Barbara
)
Regulation of intracellular HTRA1 protease
(Applicant
Ehrmann, Michael
)
Self-assembling DNA-nanoarrays containing mechanical units
(Applicant
Saccà, Barbara
)
Structure-function analysis of DegP
(Applicant
Ehrmann, Michael
)
Struktur- und Funktionsanalyse eines komplexen integralen Membranproteins aus der ABC-Transporter-Familie
(Applicant
Ehrmann, Michael
)
The network of protein quality control factors in the cell envelope of Escherichia coli
(Applicant
Ehrmann, Michael
)
Priority Programmes
Completed projects
Mechanisms of FHOD1 regulated stress fiber formation
(Applicant
Nalbant, Ph.D., Perihan
)
Optogenetic manipulation of cell contraction signal network dynamics in tumors
(Applicant
Nalbant, Ph.D., Perihan
)
Structure-function analysis of DegP and DegS
(Applicant
Ehrmann, Michael
)
Research Units
Current projects
FOR 2800: Chromosome Instability: Cross-talk of DNA replication stress and mitotic dysfunction
(Spokesperson
Bastians, Holger
)
Interaction of heparan sulfate and integrin signaling in maintaining the articular cartilage
(Applicant
Vortkamp, Andrea
)
Mutual impact of replication origin firing regulation and mitotic chromosome segregation
(Applicant
Boos, Dominik
)
Research Fellowships
Completed projects
Räumlich-zeitliche Dynamik der Cdc42 Aktivierung in lebenden, migrierenden Zellen
(Applicant
Nalbant, Ph.D., Perihan
)
Major Research Instrumentation
Completed projects
Atomic force microscope integrated with an inverted optical microscope
High-speed TIRF-SIM/SIM super-resolution microscope for live-cell imaging
Konfokales Laserscanning-Mikroskop
Marker Free Protein Analysis System
Mass Photometer-Mass Fluidics High Concentration System
Nano-LC-ESI Massenspektrometer
Nano-LC-MS Massenspektrometer mit HDX-Automation
Optical Tweezers with Confocal Fluorescence Microscop
Collaborative Research Centres
Current projects
A molecular interface linking DNA replication with cell states of different replication Competence
(Project Head
Boos, Dominik
)
Central proteomics support
(Project Head
Kaschani, Farnusch
)
Detection and modulation of cell state transitions using advanced light microscopy
(Project Head
Schulze, Nina Denise
)
Developing chemical tools for investigating cell state transitions
(Project Head
Kaiser, Markus
)
Golgi stress: impacting cell cycle transitions
(Project Head
Hellerschmied-Jelinek, Doris
)
Implications of deregulated proteostasis in cell state transitions
(Project Head
Ehrmann, Michael
)
Integrated Research Training Group on “Molecular and Chemical Cell Biology”
(Project Heads
Nalbant, Ph.D., Perihan
;
Westermann, Stefan
)
Research data management (RDM)– an integrated database and standardised analysis of ex-perimental data
(Project Heads
Meyer, Hemmo
;
Rehwald, Stephanie
;
Schulze, Nina Denise
)
Switching of spatio-temporal Rho GTPase signal network dynamics during cell cycle phase transitions
(Project Head
Nalbant, Ph.D., Perihan
)
Completed projects
Chemical tools from protein class-specific supramolecular ligands
(Project Head
Kaiser, Markus
)
DNA origami nanoarchitectures for predesigned spatial confinement of proteins
(Project Head
Saccà, Barbara
)
Supramolecular ligands modulate assembly and function of HtrA proteases
(Project Head
Ehrmann, Michael
)
Research Training Groups
Completed projects
GRK 1431: Transcription, Chromatin Structure and DNA Repair in Development and Differentiation
(Spokesperson
Meyer, Hemmo
)
GRK 1739: Molecular Determinants of the Cellular Radiation Response and their Potential for Response Modulation
(Spokesperson
Jendrossek, Verena
)
Additional Information
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