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Institution
Universität Duisburg-Essen
Campus Essen
Zentrum für Medizinische Biotechnologie (ZMB)
Address
Universitätsstraße
45141 Essen
Deutschland
GERiT
This institution in GERiT
45141 Essen
Projects
Research Grants
Current projects
Context-specific control of the Cdk8/19-cyclin C kinase by MTBP and Med12
(Applicant
Boos, Dominik
)
Dissecting mechanisms of p97-assisted protein degradation by the proteasome in the human system.
(Applicant
Meyer, Hemmo
)
Modular DNA Nanocompartments for Programmable Biomolecular Transport
(Applicant
Saccà, Barbara
)
Regulation of PP1 holoenzyme dynamics by p97-mediated structural remodelling
(Applicant
Meyer, Hemmo
)
The molecular response to endolysosomal damage and its regulation by ubiquitylation and VCP/p97
(Applicants
Behrends, Ph.D., Christian
;
Meyer, Hemmo
)
Completed projects
A semisynthetic protease DNA-nanomachine
(Applicant
Saccà, Barbara
)
Callyaerins as lead structures and chemical probes for antitubercular drug discovery
(Applicants
Kaiser, Markus
;
Kalscheuer, Rainer
)
Cellular factors implicated in amyloid fibril homeostasis
(Applicant
Ehrmann, Michael
)
Characterisation of the human serine protease HTrA1
(Applicant
Ehrmann, Michael
)
Exploration of carbohydrate metabolism in hyperthermophilic archaea: novel approaches, enzymes and metabolic pathways
(Applicants
Kaiser, Markus
;
Siebers, Bettina
)
Exploring function and dynamics in the human VCP/p97-cofactor network
(Applicant
Meyer, Hemmo
)
Extracytoplasmic protein folding stress signalling as a target for the development of novel antibiotics
(Applicants
Ehrmann, Michael
;
Kaiser, Markus
)
Genome-wide activity-based profiling of Arabidopsis proteomes
(Applicants
van der Hoorn, Renier A.L.
;
Kaiser, Markus
;
Schmidt, Jürgen
)
Implications of the human serine protease HtrA1 in Alzheimer's disease
(Applicant
Ehrmann, Michael
)
Implications of the serine protease HTRA1 in Light Chain Amyloidosis
(Applicants
Carpinteiro, Alexander
;
Ehrmann, Michael
)
Multivalency in DNA-confined spaces
(Applicant
Saccà, Barbara
)
Reconfigurable DNA-nanochambers as dynamic compartmentalization systems
(Applicant
Saccà, Barbara
)
Regulation of intracellular HTRA1 protease
(Applicant
Ehrmann, Michael
)
Replication origin firing regulation to ensure genome stability in metazoan cells
(Applicant
Boos, Dominik
)
Self-assembling DNA-nanoarrays containing mechanical units
(Applicant
Saccà, Barbara
)
Structure-function analysis of DegP
(Applicant
Ehrmann, Michael
)
Struktur- und Funktionsanalyse eines komplexen integralen Membranproteins aus der ABC-Transporter-Familie
(Applicant
Ehrmann, Michael
)
The network of protein quality control factors in the cell envelope of Escherichia coli
(Applicant
Ehrmann, Michael
)
Ubiquitin-regulated sorting of Caveolin-1 in the endosomal system
(Applicant
Meyer, Hemmo
)
Priority Programmes
Completed projects
Mechanisms of FHOD1 regulated stress fiber formation
(Applicant
Nalbant, Ph.D., Perihan
)
Optogenetic manipulation of cell contraction signal network dynamics in tumors
(Applicant
Nalbant, Ph.D., Perihan
)
Structure-function analysis of DegP and DegS
(Applicant
Ehrmann, Michael
)
VCP/p97-governed sorting of mono-ubiquitinated proteins in the endocytic pathway
(Applicant
Meyer, Hemmo
)
Research Units
Current projects
FOR 2800: Chromosome Instability: Cross-talk of DNA replication stress and mitotic dysfunction
(Spokesperson
Bastians, Holger
)
Interaction of heparan sulfate and integrin signaling in maintaining the articular cartilage
(Applicant
Vortkamp, Andrea
)
Mutual impact of replication origin firing regulation and mitotic chromosome segregation
(Applicant
Boos, Dominik
)
Research Fellowships
Completed projects
Räumlich-zeitliche Dynamik der Cdc42 Aktivierung in lebenden, migrierenden Zellen
(Applicant
Nalbant, Ph.D., Perihan
)
Major Research Instrumentation
Completed projects
Atomic force microscope integrated with an inverted optical microscope
High-speed TIRF-SIM/SIM super-resolution microscope for live-cell imaging
Konfokales Laserscanning-Mikroskop
Lattice Light-Sheet Microscope (LLSM) for fast and gentle volumetric live cell imaging
Lebendzell Spinning Disk Konfokal- und Weitfeld Imaging System mit FRAP/PA-Einheit
Marker Free Protein Analysis System
Mass Photometer-Mass Fluidics High Concentration System
Nano-LC-ESI Massenspektrometer
Nano-LC-MS Massenspektrometer mit HDX-Automation
Optical Tweezers with Confocal Fluorescence Microscop
Collaborative Research Centres
Current projects
A molecular interface linking DNA replication with cell states of different replication Competence
(Project Head
Boos, Dominik
)
Central proteomics support
(Project Head
Kaschani, Farnusch
)
Central Tasks of the Collaborative Research Centre
(Project Head
Meyer, Hemmo
)
Detection and modulation of cell state transitions using advanced light microscopy
(Project Head
Schulze, Nina
)
Developing chemical tools for investigating cell state transitions
(Project Head
Kaiser, Markus
)
Golgi stress: impacting cell cycle transitions
(Project Head
Hellerschmied-Jelinek, Doris
)
Implications of deregulated proteostasis in cell state transitions
(Project Head
Ehrmann, Michael
)
Integrated Research Training Group on “Molecular and Chemical Cell Biology”
(Project Heads
Nalbant, Ph.D., Perihan
;
Westermann, Stefan
)
Research data management (RDM)– an integrated database and standardised analysis of ex-perimental data
(Project Heads
Meyer, Hemmo
;
Rehwald, Stephanie
;
Schulze, Nina
)
SFB 1430: Molecular Mechanisms of Cell State Transitions
(Spokesperson
Meyer, Hemmo
)
Switching of spatio-temporal Rho GTPase signal network dynamics during cell cycle phase transitions
(Project Head
Nalbant, Ph.D., Perihan
)
VCP/p97-cofactor complexes at the intersection of DNA repair and checkpoint control
(Project Head
Meyer, Hemmo
)
Completed projects
Chemical tools from protein class-specific supramolecular ligands
(Project Head
Kaiser, Markus
)
DNA origami nanoarchitectures for predesigned spatial confinement of proteins
(Project Head
Saccà, Barbara
)
Probing mechanisms of the Cdc48/p97 segregase with supramolecular ligands
(Project Head
Meyer, Hemmo
)
Supramolecular ligands modulate assembly and function of HtrA proteases
(Project Head
Ehrmann, Michael
)
Research Training Groups
Completed projects
GRK 1431: Transcription, Chromatin Structure and DNA Repair in Development and Differentiation
(Spokesperson
Meyer, Hemmo
)
GRK 1739: Molecular Determinants of the Cellular Radiation Response and their Potential for Response Modulation
(Spokesperson
Jendrossek, Verena
)
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