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Institution
Justus-Liebig-Universität Gießen
Biomedizinisches Forschungszentrum Seltersberg (BFS)
Address
Schubertstraße 81
35392 Gießen
Deutschland
GERiT
This institution in GERiT
35392 Gießen
Projects
Research Grants
Current projects
Anti-schistosomal Biarylalkyl Carboxylic Acids Amides: Development and Target-Identification
(Applicants
Grevelding, Christoph G.
;
Schlitzer, Martin
)
Functional analyses of male-competence factors to unravel their role during the exceptional sex interplay in Schistosoma mansoni
(Applicant
Grevelding, Christoph G.
)
Investigation of the underlying mechanisms for the stability of mcr-1-encoding IncX4 plasmids
(Applicant
Falgenhauer, Linda
)
Strategies to protect the lung from ventilation-induced injury and fibrosis due to abnormal alveolar micromechanics
(Applicants
Knudsen, Lars
;
Maus, Ulrich A.
;
Ruppert, Ph.D., Clemens
)
Unveiling the role of G-protein-coupled receptors in Pulmonary Hypertension
(Applicant
Schermuly, Ralph
)
Completed projects
Effects of TLR9 stimulation by CpG-ODN in implant-associated bone infections caused by Staphylococcus aureus
(Applicants
Alt, Volker
;
Sethi, Shneh
)
Etablierung der RNAi-Technik, Versuch zur Transformation und Entwicklung einer Zellkultur für Schistosoma mansoni
(Applicant
Grevelding, Christoph G.
)
Genetic adaptation of non-typhoid Salmonella within human and animal reservoirs in sub-Sahara Africa
(Applicants
Dekker, Denise
;
Eibach, Daniel
;
Flieger, Antje
)
Identifizierung und Charakterisierung Ovar-exprimierter Rezeptormoleküle und Transposon-basierte Keimbahntransformation in Schistosoma mansoni
(Applicant
Grevelding, Christoph G.
)
Identifizierung und Charakterisierung von Genen mit essentieller Funktion für die Entwicklung von Schistosomen-Weibchen
(Applicant
Grevelding, Christoph G.
)
Relative role and interdependence of urokinase and hepatocyte growth factor in mediating epithelial cell-protective effects in lung fibrosis
(Applicant
Ruppert, Ph.D., Clemens
)
Role of Dimethylarginine Dimethylaminohydrolase (DDAH) in vascular and parenchymal lung diseases
(Applicant
Schermuly, Ralph
)
Role of mast cells in pressure overload induced right ventricular remodeling and failure
(Applicant
Schermuly, Ralph
)
Role of Porphyromonas gingivalis Fimbriae in infection of oral epithelial cells
(Applicants
Domann, Eugen
;
Gröger, Sabine Elisabeth
)
Role of tyrosine kinases in the pathogenesis of pulmonary arterial hypertension
(Applicant
Schermuly, Ralph
)
Schistosoma mansoni: Molecular genetic effects following inhibitor treatment; functional characterization of differentially expressed genes potentially involved in regulating mitoses and egg-formation processes
(Applicant
Grevelding, Christoph G.
)
Stellenwert der enzymatisch vermittelten Konversion pulmonalen Surfactants bei akuter respiratorischer Insuffizienz - Entwicklung therapeutischer Ansätze
(Applicant
Ruppert, Ph.D., Clemens
)
Surfactant inactivation, alveolar collapsibility and their role in the progression to pulmonary fibrosis in animal models of lung injury and fibrosis
(Applicants
Hoymann, Ph.D., Heinz-Gerd
;
Knudsen, Lars
;
Ruppert, Ph.D., Clemens
)
Tyrosine kinase inhibition in pulmonary hypertension: experimental and clinical studies
(Applicant
Ghofrani, Hossein Ardeschir
)
Collaborative Research Centres
Current projects
Inflammatory lung microenvironment in lung cancer-associated pulmonary hypertension
(Project Heads
Ghofrani, Hossein Ardeschir
;
Grimminger, Friedrich
;
Schermuly, Ralph
;
Weiß, Astrid
)
Completed projects
Cryoelektronenmikroskopie
(Project Head
Hardt, Martin
)
Der Internalisierungsvorgang von Listeria monocytogenes in Eukaryonten und die Charakterisierung der daran beteiligten Faktoren
(Project Head
Domann, Eugen
)
Identifizierung und Charakterisierung von Genen mit essentieller Funktion für die Entwicklung von Schistosomen-Weibchen
(Project Head
Grevelding, Christoph G.
)
Phosphodiesterase-Inhibitoren und Aktivatoren/Stimulatoren der löslichen Guanylatzyklase zur Induktion von "Reverse Remodeling" bei pulmonaler Hypertonie
(Project Head
Schermuly, Ralph
)
The role of HIF-1 and its regulators p53 and Smyd2 in right ventricular hypertrophy and failure
(Project Heads
Novoyatleva, Tatyana
;
Schermuly, Ralph
)
Tyrosinkinase Inhibition zur antiproliferativen Therapie kardiopulmonaler Erkrankungen
(Project Heads
Grimminger, Friedrich
;
Schermuly, Ralph
)
Priority Programmes
Current projects
Biomechanics of the Platyhelminth Adhesion, Locomotion, and Reproduction
(Applicants
Grevelding, Christoph G.
;
Häberlein, Simone
;
Mosig, Alexander
;
Schacher, Felix H.
)
Completed projects
Role of Listeriolysin (LLO) in Listeria monocytogenes-infected host cells
(Applicant
Domann, Eugen
)
Clinical Research Units
Completed projects
Pathogenetische Rolle und therapeutischer Nutzen des pulmonalen Surfactant-Systems bei fibrosierenden Lungenerkrankungen
(Applicant
Günther, Andreas
)
Rolle der HIF/VEGF-Achse bei der Bronchopulmonalen Dysplasie (BPD): Entwicklung pharmakologischer und molekularer Interventionsstrategien
(Applicant
Schermuly, Ralph
)
CRC/Transregios
Completed projects
Novel pathways of neutrophil-endothelial cell interaction in acute bacterial pneumonia: impact on transmigration kinetics and organ failure
(Project Heads
Santoso, Sentot
;
Schermuly, Ralph
)
Role of ER stress in SARS-CoV-2 lung infection
(Project Heads
Abu Mraheil, Mobarak
;
Chakraborty, Trinad
;
Hippenstiel, Stefan
;
Pillich, Helena
)
Research Training Groups
Completed projects
GRK 370: Biochemistry of Nucloeprotein Complexes
(Spokesperson
Pingoud, Alfred
)
International Research Training Groups
Completed projects
GRK 1062: Signalling Mechanisms in Lung Physiology and Disease (SMLPD)
(Spokesperson
Seeger, Werner
)
Clusters of Excellence
Completed projects
EXC 147: Cardio-Pulmonary System
(Spokespersons
Dimmeler, Stefanie
;
Seeger, Werner
;
Zeiher, Andreas Michael
)
Clusters of Excellence (ExStra)
Current projects
EXC 2026: Cardio-Pulmonary Institute (CPI)
(Spokespersons
Dimmeler, Stefanie
;
Seeger, Werner
)
Additional Information
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