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Professorin Dr. Ana Jesús Garcia Sáez

Address Max-Planck-Institut für Biophysik
Abteilung für Membran-Dynamik
Max-von-Laue-Straße 3
60438 Frankfurt am Main

Projects

As Applicant
- Current projects
  - The wave of death: ferroptosis propagation from single cell death to tissue damage (Priority Programmes)
- Completed projects
  - Structural dynamics of membrane-bound BAX oligomers: intramolecular flexibility vs population heterogeneities (Research Grants)
  - Stoichiometry of homo- and hetero-complexes of Bcl-2 proteins at the single molecule level (Research Units)
  - Mechanisms of MLKL in necroptosis: from intramolecular rearrangements to isoform regulation (Research Grants)
As Leader
- Completed projects
  - Konfokales Mikroskop mit FCS-Modul (Major Research Instrumentation)
  - 3D STED Super-resolution Confocal Microscope (Major Research Instrumentation)
As Participating Researcher
- Current projects
  - EXC 2180: Image-Guided and Functionally Instructed Tumor Therapies (iFIT) (Clusters of Excellence (ExStra))
As Project Head
- Current projects
  - Understanding resistance towards venetoclax in lymphoma: physiology of genetic alterations in BTG1 and BCL2 (Collaborative Research Centres)
  - Necroptosis in aortic aneurysm disease - significance of inflammation in MLKL dependent cell death (CRC/Transregios)
  - Death pores: decision-making at the execution step of regulated necrosis (CRC/Transregios)
  - Cross-talk between dying and bystander cells in vitro and in vivo: an optogenetics approach (Collaborative Research Centres)
  - Ultra-structure of the plasma membrane harbouring MLKL oligomers and MLKL-mediated Ca2+ influx during plant and animal immunogenic cell death (Collaborative Research Centres)
  - Dynamic architecture of DRP1 macromolecular assemblies in mitochondrial fission (Collaborative Research Centres)
  - Mitochondrial structure and dynamics in light and electron microscopy (Collaborative Research Centres)
- Completed projects
  - Effect of Bcl-2 proteins on mitochondrial structure, dynamics and function (Collaborative Research Centres)

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