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Institution
Philipps-Universität Marburg
Fachbereich Pharmazie
Institut für Pharmazeutische Chemie
Address
Marbacher Weg 6-10
35037 Marburg
Deutschland
GERiT
This institution in GERiT
35037 Marburg
Projects
Research Grants
Current projects
Dissecting the co-transcriptional processing of human mitochondrial mRNAs
(Applicant
Tan, Ph.D., Benedict
)
Exploiting the potential of allostery in the 5-HT2A receptor as a new paradigm for schizophrenia treatments
(Applicants
Kolb, Peter
;
Shahraki, Ph.D., Aida
)
Structure-based development of novel broad-spectrum antiviral inhibitors through inhibition of the human eIF4A-RNA complex
(Applicants
Grünweller, Arnold
;
Schlitzer, Martin
)
The inner workings of the μ-opioid receptor: Elucidating the role of individual residues in translating ligand binding to G protein activation
(Applicant
Heydenreich, Franziska
)
Completed projects
17beta-Hydroxysteroid Dehydrogenase Type 14: Development of potent and selective inhibitors using crystallization-aided optimization and enzyme characterization
(Applicants
Klebe, Gerhard
;
Marchais-Oberwinkler, Sandrine
)
Anti-schistosomal Biarylalkyl Carboxylic Acids Amides: Development and Target-Identification
(Applicants
Grevelding, Christoph G.
;
Schlitzer, Martin
)
Catalysis by an "RNA-free" RNase P
(Applicant
Hartmann, Roland K.
)
Charakterisierung bakterieller Ribonuklease P sowie der tRNA-Prozessierung in Aquifex aeolicus
(Applicant
Hartmann, Roland K.
)
Comparison of protein binding cavities with neural networks: from structure to function and drug design
(Applicant
Ultsch, Alfred
)
Computer-aided tailoring of the efficacy profiles of G protein-coupled receptor ligands
(Applicant
Kolb, Peter
)
Design, Synthese und in vitro-Testung neuer nAChR-Liganden: Bioisostere der hochtoxischen Alkaloide (+)-Anatoxin-a, (-)-Ferruginin und (-)-Cytisin
(Applicant
Seitz, Gunther
)
Design, synthesis and molecular characterization of selective inverse agonists and antagonists of the Peroxisome Proliferator-Activated Receptor (PPAR) beta/delta
(Applicants
Adhikary, Till
;
Diederich, Wibke Elisabeth
)
Development of improved fosmidomycin derivates
(Applicant
Schlitzer, Martin
)
Development of small molecule inhibitors and stabilizers of dimerization of tRNA-guanine transglycosylase to treat Shigellosis
(Applicant
Klebe, Gerhard
)
Expression, purification, structural and biochemical characterization of the hemagglutinin-cleaving proprotein convertase PC5
(Applicant
Hardes, Kornelia
)
Halbleiterbasierte Zwei-Photonen-Mikroskopie zur Untersuchung der Stoffwechselleistung von tierischen Zellen
(Applicants
Keusgen, Michael
;
Moritz, Werner
)
Kreuzkorrelation von Proteinbindetaschen zum Erkennen verwandter Bindungsepitope, unerwarteter Nebenwirkungsprofile und funktioneller Verwandtschaften
(Applicant
Klebe, Gerhard
)
Kristallisation und Röntgenstrukturanalyse eines Komplexes der S-Adenosylmethionin: tRNA-Ribosyltransferase-Isomerase (QueA) mit einem kognaten tRNA-Substrat
(Applicant
Klebe, Gerhard
)
Molecaular mechanisms underlying the activation of muscarinic M1-, M3- and M5-receptors by the membrane potential
(Applicant
Rinne, Andreas
)
Ribonuklease P - Untersuchungen zum Spaltmechanismus, zur Substrat- und Produkt-Bindung sowie zur Identifizierung und Charakterisierung wichtiger funktioneller Gruppen der katalytischen RNA-Untereinheit bakterieller Enzyme
(Applicant
Hartmann, Roland K.
)
SARS-CoV-2-RNA: Understanding the RNA architecture of SARS-CoV-2
(Applicants
Schwalbe, Harald
;
Weigand, Julia Erika
;
Wöhnert, Jens
)
Selektion von RNA-Aptameren gegen Schlüsselkomponenten bei der Endotoxin-vermittelten Sepsis
(Applicant
Hartmann, Roland K.
)
Specific Inhibition of a Conformationally Flexible t-RNA Modifying Enzyme by Ligands Synthesized by Combinatorial Chemistry
(Applicant
Link, Andreas
)
Specific Inhibition of an Conformationally Flexible t-RNA Modifying Enzyme by Ligands Synthesized by Combinatorial Chemistry
(Applicant
Klebe, Gerhard
)
Specifying the rules for target recognition and regulation by Roquin in vivo
(Applicant
Weigand, Julia Erika
)
Structural chemistry of inhibitor binding to Aldose Reductase: An integrated approach combining subatomic resolution crystallography, microcalorimetry, multipolar modeling and quantum modeling
(Applicant
Klebe, Gerhard
)
Structure, function and evolution of the novel PIN_5 domain-type RNases P
(Applicant
Hartmann, Roland K.
)
Strukturbasiertes Design, Synthese und strukturbiologische Charakterisierung von Apartylprotease-Inhibitoren - Zielproteine für HIV- und Malaria-Infektionen
(Applicants
Diederich, Wibke Elisabeth
;
Klebe, Gerhard
)
Strukturbiologische Untersuchungen Shigellen-spezifischer Pathogenitätsfaktoren als Grundlage für rationelles Wirkstoff-Design
(Applicant
Klebe, Gerhard
)
Strukturvariationen des Arzneistoffs Colchicin
(Applicant
Seitz, Gunther
)
Understanding the Binding Characteristics of Aldose Reductase
(Applicants
Klebe, Gerhard
;
Schlitzer, Martin
)
Research Fellowships
Completed projects
Activation mechanisms of Class F GPCRs – from structural understanding to novel therapeutics
(Applicant
Schihada, Hannes
)
Synthese von Strukturanaloga sowie von affinity labels des Naturstoffs Salicylihalamid A zur Untersuchung von Struktur-Wirkungsbeziehungen sowie zur Charakterisierung der Interaktion von Salicyclihalamiden mit ihrem biologischen Target
(Applicant
Diederich, Wibke Elisabeth
)
Priority Programmes
Current projects
Machine-Learning-guided chemical space exploration: automatic creation and navigation of ultra-large open-source molecular libraries
(Applicant
Kolb, Peter
)
Completed projects
Directed evolution to understand enzyme function of almost protein independent bacterial RNase P RNA versus largely protein-dependent archaeal RNase P RNA
(Applicant
Hartmann, Roland K.
)
Structural and functional aspects of the small riboregulator 6S RNA
(Applicant
Hartmann, Roland K.
)
Research Units
Completed projects
Metallhybridenzyme zur Katalyse von Click-Chemie-Reaktionen
(Applicants
Klebe, Gerhard
;
Koert, Ulrich
)
Perturbance of enzyme function by blocking dimer interface formation: Novel route to specific antibiotics
(Applicant
Klebe, Gerhard
)
Emmy Noether Independent Research Groups
Current projects
Decoding the conformational diversity of heterotrimeric G proteins that defines receptor-specific signaling
(Applicant
Schihada, Hannes
)
Completed projects
Understanding and predicting the specificity of small molecule protein interactions
(Applicant
Kolb, Peter
)
Heisenberg Professorships
Completed projects
In silico tailoring of ligands for G protein-coupled receptors: designing selectivity, efficacy and molecular structures
(Applicant
Kolb, Peter
)
Heisenberg Grants
Completed projects
In silico tailoring of ligands for G protein-coupled receptors: designing selectivity, efficacy and molecular structures
(Applicant
Kolb, Peter
)
Major Research Instrumentation
Completed projects
400 MHz NMR-Konsole
Collaborative Research Centres
Completed projects
High-throughput identification of conserved structures in mRNAs
(Project Head
Weigand, Julia Erika
)
Mechanisms and regulation of Ebola virus RNA synthesis
(Project Heads
Becker, Stephan
;
Biedenkopf, Nadine
;
Hartmann, Roland K.
)
CRC/Transregios
Completed projects
Chemoinformatics, Medicinal Chemistry & Peptidomimetics
(Project Heads
Diederich, Wibke Elisabeth
;
Kolb, Peter
;
Vazquez, Olalla
)
Research Training Groups
Current projects
GRK 2355: Regulatory networks in the mRNA life cycle: from coding to noncoding RNAs
(Spokesperson
Sträßer, Katja
)
GRK 2937: Nucleotide Metabolism in Microbes
(Spokesperson
Graumann, Peter
)
Completed projects
GRK 541: Protein Function at the Atomic Level
(Spokesperson
Buckel, Wolfgang
)
International Research Training Groups
Completed projects
GRK 1384: Enzymes and Multienzyme Complexes Acting on Nucleic Acids
(Spokesperson
Friedhoff, Peter
)
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