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Institution
Constructor University
School of Science
Department of Life Sciences and Chemistry
Address
Campus Ring 1
28759 Bremen
Deutschland
GERiT
This institution in GERiT
28759 Bremen
Projects
Priority Programmes
Completed projects
Auto-regulation of the thyroid gland by classical and non-classical pathways
(Applicant
Brix, Klaudia
)
Highly Robust and Efficient Water Oxidation Catalysts based on Nanoscopic Metal Oxide Species (Polyoxometalates): from Fundamental Science to Devices
(Applicants
Kortz, Ph.D., Ulrich
;
Vankova, Nina
)
London Dispersion Interactions inside Macrocycles
(Applicant
Nau, Werner
)
Organo-Ruthenium substituted Polyoxoanions and Their Homogeneous Oxidation Catalysis Properties
(Applicant
Kortz, Ph.D., Ulrich
)
Regulation des Metabolittransportes über die äußere Chloroplastenhüllmembran
(Applicant
Wagner, Richard
)
SPP1629 coordination project
(Applicants
Biebermann, Heike
;
Brix, Klaudia
;
Führer-Sakel, Dagmar
)
Synthesis and Structural Characterization of Lanthanide Containing Polyoxoanions Functionalized by Peroxo Groups, and Investigation of Their Catalytic Properties
(Applicant
Kortz, Ph.D., Ulrich
)
Synthesis and Structural Characterization of Transition Metal-Substituted Polyoxoanions and Investigation of Their Unique Magnetic Properties
(Applicant
Kortz, Ph.D., Ulrich
)
Untersuchungen zur Funktionalisierung von Bor-Dekaedern und -Dodekaedern mit organischen Resten über Bor-Kohlenstoff- und Bor-Heteroatom-Kohlenstoffbindungen
(Applicant
Gabel, Detlef
)
Research Grants
Current projects
Cell surface clusters of MHC class I molecules: origin, structure, and functions
(Applicant
Springer, Sebastian
)
Chaotropic Polyoxometalates: From Fundamentals to Applications
(Applicants
Kortz, Ph.D., Ulrich
;
Nau, Werner
)
Cross-talk between energy supply and drug translocation in the ABC transporter Pdr5
(Applicants
Schmitt, Lutz
;
Wagner, Richard
)
Data-driven development of an enzyme cascade for the synthesis of cyclic dinucleotides
(Applicant
Rosenthal, Katrin
)
Deciphering the rules of genome binding specificity: de-novo design of intrinsically disordered regions directing transcription factor binding.
(Applicant
Jonas, Felix
)
Decrypting MHC class I trafficking in cross-presentation
(Applicant
Springer, Sebastian
)
Enantioselective Ammonium Enolate Based Michael-Henry and Michael-Henry-Aldol Cascade Reactions: Development, Mechanistic Insight, and Applications for Morphine Family Analgesics
(Applicant
Nugent, Thomas
)
Extension of the substrate range of the cell factory Saccharomyces cerevisiae to use C1-derived feedstocks: succinic acid as a model target product
(Applicant
Nevoigt, Elke
)
Mechanisms and consequences of functional divergence in transcription factor paralogs
(Applicant
Jonas, Felix
)
Metabolic engineering of bakers yeast for more efficient respiratory and fermentative glycerol utilization
(Applicant
Nevoigt, Elke
)
Supramolecular Tandem Membrane Assays
(Applicants
Hennig, Andreas
;
Nau, Werner
)
Synthesis and Host-Guest Chemistry of Organically-Functionalized Polyoxomolybdate Wheels
(Applicant
Kortz, Ph.D., Ulrich
)
Synthesis of Noble Metal-oxo Cluster-based Metal-Organic Frameworks and their Use in Heterogeneous Catalysis and Magnetism
(Applicant
Kortz, Ph.D., Ulrich
)
The causes of MHC-I-opathies in cellular stress
(Applicant
Springer, Sebastian
)
Completed projects
Analysis of control types in transcriptional regulation
(Applicant
Hütt, Marc-Thorsten
)
Das Permeom der mitochondrialen Außenmembran: Elektrophysiologische und molekulare Identifizierung neuer Kanalproteine
(Applicants
Meisinger, Chris
;
Wagner, Richard
)
Diatoms - widespread nitrate respirers with overlooked impact on the marine nitrogen cycle
(Applicant
Kamp, Anja
)
Diazaborane des Typs (RNH2)B8H11NHR als neuartige Clustersysteme für die Bor-Neutroneneinfangtherapie
(Applicant
Gabel, Detlef
)
Enantioselective Conversion of Achiral Diketones and Triketones for Shortened Bioactive Molecule Synthesis
(Applicant
Nugent, Thomas
)
Endocytic sorting of MHC class I molecules
(Applicant
Springer, Sebastian
)
Enhancement of peptide binding to MHC class I molecules by small compounds - a combined biochemical and computational investigation
(Applicants
Springer, Sebastian
;
Zacharias, Martin
)
Entschlüsselung des Temperatursondierungsmechanismus der Histidinproteinkinase CorS aus Pseudomonas syringae
(Applicant
Ullrich, Matthias S.
)
Entwicklung von Elektrolytkomponenten und Additiven insbesondere zur Filmbildung an der Kathode von wieder aufladbaren Lithium-Ionen-Batterien
(Applicants
Röschenthaler, Gerd-Volker
;
Winter, Martin
)
ENVICOPAS - IMPACT OF ENVIRONMENTAL CHANGES ON COASTAL PATHOGEN SYSTEMS (ENVICOPAS)
(Applicants
Feudel, Ulrike
;
Gerdts, Gunnar
;
Ullrich, Matthias S.
;
Wegner, Mathias
)
ERA NanoSci - Novel force spectroscopy with nanopores
(Applicant
Winterhalter, Mathias
)
Fine-tuning the glycerol biosynthetic pathway in Saccharomyces cerevisiae to optimize the biotechnological production of bio-fuel ethanol and L-glycerol 3-phosphate (L-G3P)
(Applicant
Nevoigt, Elke
)
Fluorescence techniques applied to root-state detection in protein folding
(Applicant
Nau, Werner
)
From masked carbenes to heterocycles: Novel potentially biological active difluoromethylene phosphonates as versatile building blocks
(Applicant
Röschenthaler, Gerd-Volker
)
Funktion biologischer Variabilität bei der Musterbildung von Dictyostelium discoideum
(Applicant
Hütt, Marc-Thorsten
)
Funktion biologischer Variabilität bei der Musterbildung von Dictyostelium discoideum
(Applicant
Hauser, Marcus
)
Funktion von Cysteinproteasen im Dünndarm von Mäusen
(Applicant
Brix, Klaudia
)
Genome-wide analysis of multidrug efflux in the plant-pathogenic bacterium Pseudomonas syringae
(Applicant
Ullrich, Matthias S.
)
Hochauflösende kinetische Untersuchung zum molekularen Mechanismus von Glutamat-Transportern: Intra- und Intermolekulare Wechselwirkungen
(Applicant
Rauen, Thomas
)
Investigation of structure and function of bacterial porins with special emphasis on their role in physiology of Borrelia and related species
(Applicant
Benz, Roland
)
Ion and antibiotics transport through the phosphate specific outer membrane porins OprP and OprO
(Applicants
Benz, Roland
;
Kleinekathöfer, Ulrich
)
Liposomen mit Bor-haltigen Lipiden zur Neutroneneinfang-Therapie
(Applicants
Gabel, Detlef
;
Schubert, Rolf
)
Molecular cell biology of MHC class I retention by the gp40 protein of the murine cytomegalovirus
(Applicant
Springer, Sebastian
)
Molecular characterization of the aggregate formation-inducing interaction between Marinobacter adhaerens HP15 and the diatom, Thalassiosira weissflogii
(Applicant
Ullrich, Matthias S.
)
Neue fluorierte Bor-, Aluminium-, Phosphor-, Sauerstoff- und Schwefel-zentrierte Anionen; Elektrolyte, Redox-Shuttle und Additive
(Applicant
Röschenthaler, Gerd-Volker
)
Novel synthetic approaches towards organic sulfur pentafluorides
(Applicant
Röschenthaler, Gerd-Volker
)
Organization of excitable dynamics in hierarchical networks - Theoretical analysis, numerical simulation and application to neuroscience
(Applicant
Hütt, Marc-Thorsten
)
PolyoxoNobleMetalate Chemistry Merged with Metal-Organic Frameworks: A Novel Class of Heterogeneous Catalysts
(Applicant
Kortz, Ph.D., Ulrich
)
Polypeptide dynamics and structure studied simultaneously by collision-induced fluorescence quenching and resonance energy transfer in the 10-Å domain
(Applicant
Nau, Werner
)
Regulation des Metabolittransportes über die äußere Chloroplastenhüllmembran
(Applicant
Wagner, Richard
)
SARS-CoV-2 Spike Protein-Priming Cysteine Cathepsin L Acting at Microvilli of Intestine Epithelial Cells
(Applicant
Brix, Klaudia
)
Selective Passivation of Electrical Defects in Metal Oxides
(Applicants
Röschenthaler, Gerd-Volker
;
Wagner, Veit
)
Small molecules to manipulate peptide binding to MHC class I molecules, an optimized method for the generation of MHC tetramers by peptide exchange
(Applicant
Springer, Sebastian
)
Strukturelle Dynamik und Regulation des Sec61p-Komplexes
(Applicant
Wagner, Richard
)
Study of cell wall permeability of bacteria from the order Actinomycetales with special emphasis on structure and function of cell wall channels
(Applicant
Benz, Roland
)
Supramolecular Chemistry of Boron Clusters with Cyclodextrins: From Synthesis to Applications
(Applicants
Gabel, Detlef
;
Nau, Werner
)
Supramolecular tandem assays for monitoring enzymatic activity
(Applicant
Nau, Werner
)
Supramolecular Tandem Membrane Assays
(Applicants
Hennig, Andreas
;
Nau, Werner
)
Synchronization emergence in manufacturing systems and its effect on logistic performance
(Applicants
Arlinghaus, Julia
;
Hütt, Marc-Thorsten
)
Synthese und Eigenschaften liposomal gebundener Eisen-Schwefel-Cluster (Modelle von Eisen-Schwefel-Enzymen)
(Applicants
Gabel, Detlef
;
Weigand, Wolfgang
)
Synthesis and Structure of Ti-, Zr- and Hf-Containing Polyoxotungstates and Study of their Oxidation Catalysis Properties
(Applicant
Kortz, Ph.D., Ulrich
)
The First Broad Examination of Michael Reactions in the Presence of a Diverse Array of Acidic Spectator Functional Groups: Enantioselective Synthesis
(Applicant
Nugent, Thomas
)
The intracellular quality control mechanism of major histocompatibility complex class I molecules studied by controlled peptide delivery to cells - a combined cell biological, biochemical, and biophysical investigation
(Applicant
Springer, Sebastian
)
The Network Interface between Gene Regulation and Metabolism - Mathematical Description, Dynamics, and Evolutionary Design Principles
(Applicants
Bornholdt, Stefan
;
Hütt, Marc-Thorsten
)
The Regulated Intracellular Trafficking and Function of the Chaperones of the MHC Class I Peptide Loading Complex
(Applicant
Springer, Sebastian
)
The role of the dual compartment protein raver1 in cell polarity
(Applicant
Illenberger, Susanne
)
Transcriptional regulation, differential secretion, and eco-physiological function(s) of levansucrase in the plant pathogen, Pseudomonas syringae
(Applicant
Ullrich, Matthias S.
)
Untersuchung der Struktur und Funktion spezifischer Porine von Gram-negativen Bakterien
(Applicant
Benz, Roland
)
Untersuchung der Zellwandpermeabilität von Actinomyceten
(Applicant
Benz, Roland
)
Wirkmechanismen bei der Interaktion zwischen dem Antagonisten Pseudomonas syringae pv. syringae 22d/93, dem Pathogen Pseudomonas syringae pv. glycinea und der Sojabohne
(Applicant
Ullrich, Matthias S.
)
Research Units
Completed projects
Assembly of the Peroxisomal Translocon
(Applicants
Erdmann, Ralf
;
Sattler, Michael
;
Wagner, Richard
)
FOR 1905: Structure and Function of the Peroxisomal Translocon (PerTrans)
(Spokesperson
Erdmann, Ralf
)
Funktion und Regulation muskelspezifischer Strukturproteine während der Myogenese
(Applicant
Illenberger, Susanne
)
Funktion von Cysteinproteasen für die Migration und Differenzierung von Keratinocyten in der Regenerationsphase nach Verletzung der Haut
(Applicant
Brix, Klaudia
)
Genetische und biochemische Untersuchungen zur Funktion des "Dual Compartment-Proteins" Raver-1: Analyse von k.o. Maus-Mutanten
(Applicant
Arnold, Hans-Henning
)
Structural dynamics and regulation of the Sec61 complex
(Applicants
Wagner, Richard
;
Zimmermann, Richard
)
Clinical Research Units
Completed projects
Extrazelluläre Proteolyse nach operativer Schädigung des Darmepithels
(Applicant
Brix, Klaudia
)
Collaborative Research Centres
Completed projects
Die Bedeutung von Cathepsinen für die extrazelluläre Proteolyse an Zelloberflächen
(Project Head
Brix, Klaudia
)
Differentielle Expression und Sekretion von Levansucrase aus dem Bodenbakterium Pseudomonas fluorescens
(Project Head
Ullrich, Matthias S.
)
Mechanismen des Proteintransportes über die Chloroplasten- und Mitochondrienmembran
(Project Head
Wagner, Richard
)
Mechanism of protein transport across chloroplast and mitochondrial membranes
(Project Head
Wagner, Richard
)
Mechanismus und Pharmakologie des Toxintransports an Modellmembranen
(Project Head
Benz, Roland
)
Mechanismus und Pharmakologie des Toxintransports an Modellmembranen
(Project Head
Benz, Roland
)
Research Fellowships
Completed projects
Variabilität in Netzwerken nichtlinearer Oszillatoren: Theoretische Studien und Anwendung auf raumzeitliche Dynamiken in der Biologie
(Applicant
Hütt, Marc-Thorsten
)
Major Research Instrumentation
Completed projects
Flüssigkeitschromatographie gekoppeltes Ionenfallen-Massenspektrometer
High-resolution chromatography coupled ion mobility electrospray ionization mass spectrometer
Laser Scanning Microscope (LSM)
Single crystal X-ray diffractometer
International Research Training Groups
Completed projects
GRK 587: Regulation of Genes and Pathogens, Host Response during Infectious Diseases, Detection of Substances Influencing Gene Expression and Pathogens
(Spokesperson
Morschhäuser, Joachim
)
GRK 1141: Signal transduction: where cancer and infection converge
(Spokesperson
Rapp, Ulf Rüdiger
)
Core Facilities
Completed projects
MALDI Imaging Mass Spectrometry and Multi-Array Core Facility: MALDI-MULTI
(Applicant
Maedler, Ph.D., Kathrin
)
Research Training Groups
Completed projects
GRK 340: Communication in Biological Systems: From the Molecule to the Organism in the Environment
(Spokesperson
Pfeifer, Felicitas
)
GRK 612: Molecular Physiology: Interactions between Cellular Nanostructures
(Spokesperson
Brandt, Roland
)
Additional Information
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