Project Details

Professor Dr. Markus F. Neurath

Address Universitätsklinikum Erlangen AöR
Medizinische Klinik 1
Gastroenterologie, Pneumologie und Endokrinologie
Ulmenweg 18
91054 Erlangen

Projects

As Applicant
- Current projects
  - Deciphering immune interactions between human iPSC-derived enteric neural lineages and 3D intestinal epithelial organoids in mucosal inflammation (Clinical Research Units)
  - Tec kinase ITK-dependent signaling pathways in the resolution of inflammation in ulcerative colitis (Research Grants)
- Completed projects
  - Cytokine gene transcription of IL-12 in IBD (Research Grants)
  - Mechanisms of microbiota induced IL-23/Th17 immune responses in chronic colitis (Priority Programmes)
  - Characterization and expansion of regulatory T cells for cell-based therapy of Inflammatory bowel disease (IBD) (Clinical Research Units)
  - Analysis and functional modulation of the cross-talk between pSTAT3high cancer-associated fibroblasts and tumor cells in colorectal cancer (Research Units)
  - IL-20-mediated suppression of pro-inflammatory epithelial STAT2 signaling in mucosal healing and inflammatory bowel disease (Research Grants)
As Leader
- Completed projects
  - Tischdurchflusszytometer (Major Research Instrumentation)
  - Konfokales Laserscanning-Mikroskop (Major Research Instrumentation)
  - Multimodales Kleintier-Bildgebungsgerät (Major Research Instrumentation)
  - MicroCT-Einheit (Major Research Instrumentation)
  - Multispektraler optoakustischer Tomograph (Major Research Instrumentation)
As Spokesperson
- Completed projects
  - KFO 257: Molecular Pathogenesis and Optimised Therapy of Inflammatory Bowel Diseases (Clinical Research Units)
As Participating Researcher
- Completed projects
  - GSC 80: Erlangen Graduate School in Advanced Optical Technologies (SOAT) (Graduate Schools)
As Project Head
- Current projects
  - A phase II multi-center clinical trial to study the efficacy and in vivo trafficking of autologous adoptively transferred ex vivo expanded regulatory T cells in patients with ulcerative colitis (CRC/Transregios)
  - KFO 5024: Immune checkpoints of gut to brain communication in inflammatory and neurodegenerative diseases (GB.Com) (Clinical Research Units)
- Completed projects
  - Analyse der pathogenetischen Bedeutung von Epstein-Barr virus induced gene 3 (EBI-3) bei der Persistenz bakteriell induzierter intestinaler Entzündungsreaktionen (Collaborative Research Centres)
  - Molekulare Analyse der pathogenetischen Bedeutung von GATA-3 und NFAT-Tanskriptionsfaktoren bei chronisch entzündlichen Darmerkrankungen (Collaborative Research Centres)
  - Analyse der pathogenetischen Bedeutung von Epstein-Barr viruinduced gene 3 (EBI3) und IL-27 bei der Persistenz bakteriell induzierter Entzündungsreaktionen (Collaborative Research Centres)
  - Molecular analysis of TGF-beta signal transduction in the immunopathogenesis of sporadic and colitis associated colorectal cancer (Collaborative Research Centres)
  - Transcriptional Regulation and Pathogenetic Relevance of IL-28/IL-29 Cytokine System in Colitis and Colitis Associated Colon Carcinoma (CRC/Transregios)
  - Regulation and Pathogenetic Relevance of the IL-28/IL-28R Signaling Pathway in Experimental Colitis and Inflammatory Bowel Diseases (Collaborative Research Centres)
  - Functional analysis of bacterial Type VI effectors in EBI3-dependent regulation of enteric infection and inflammation (Collaborative Research Centres)
  - Tec kinase ITK-dependent signaling pathways in the resolution of inflammation in ulcerative colitis (Collaborative Research Centres)
As Participating Person
- Completed projects
  - TH2 Zytokine in der Pathogenese des Colitis-assoziierten Colonkarzinoms: Molekulare und immuntoxikologische Untersuchungen (Research Units)
  - Molecular analysis of intestinal stem cells in the context of premature aging, chronic inflammation and colorectal carcinogenesis (Research Grants)
  - Identification of molecular mechanisms of cholestatic pruritus (Research Grants)

Servicenavigation

Hauptnavigation

Professor Dr. Markus F. Neurath

Additional Information

Servicenavigation

Hauptnavigation

Professor Dr. Markus F. Neurath

Additional Information

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