SFB 1310:  Predictability in Evolution

• Subject Area: Biology ; Medicine
• Term: since 2018
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325931972

No abstract available

• DFG Programme: Collaborative Research Centres
• International Connection: Netherlands, USA

Current projects

• A01 - Cellular mechanisms of drug resistance evolution (Project Heads Bollenbach, Tobias ;  Macaluso, Francesca )
• A02 - Predicting evolutionary pathways to β-lactam resistance (Project Heads Ernst, Christoph ;  Krug, Joachim ;  de Visser, Arjan G.M. )
• A04 - Predicting metabolic evolution in the minimal cell (Project Heads Lercher, Martin ;  Pang, Tin Yau )
• A05 - Fitness effects of cross-species gene transfer in bacteria (Project Head Maier, Berenike )
• A07 - Predicting the evolution of multi-drug resistance in Mycobacterium tuberculosis (Project Head Rybniker, Ph.D., Jan )
• B01 - Leaving footprints: How immune imprinting shapes vaccine responses and viral evolution (Project Head Klein, Florian )
• B02 - Predicting viral-immune co-evolution (Project Head Lässig, Michael )
• B04 - Impact of aging on immune responses to pathogenic challenges (Project Heads Dönertas, Handan Melike ;  Valenzano, Ph.D., Dario Riccardo )
• C01 - Predicting and controlling resistance evolution against targeted/ferroptotic combination therapies (Project Heads Berg, Johannes ;  Brägelmann, Johannes ;  von Karstedt, Silvia )
• C02 - Mapping the fitness landscapes of metastasizing cancers (Project Heads Beyer, Andreas ;  Hillmer, Axel )
• C03 - Predicting therapy resistance in human cancer (Project Heads Bozek, Katarzyna ;  Büttner, Reinhard )
• C04 - The fitness landscape of BRCA2 loss and therapy resistance across cancers (Project Heads Büttner, Reinhard ;  Hillmer, Axel )
• C05 - Immuno-metabolic fitness models for cancer evolution (Project Heads Frezza, Christian ;  Luksza, Marta ;  Lässig, Michael )
• Z01 - Central activities (Project Head Lässig, Michael )
• Z02 - Technology for massively parallel laboratory evolution (Project Heads Bollenbach, Tobias ;  Kreer, Christoph ;  Maier, Berenike )
• Z03 - Evolutionary bioinformatics (Project Heads Beyer, Andreas ;  Kovacova, Viera ;  Lässig, Michael )

Completed projects

• A03 - Predicting evolutionary shifts of cell metabolism (Project Head Lässig, Michael )
• B03 - Adaptive immune control of evolving pathogens (Project Head Nour Mohammad, Armita )
• B06 - Evolutionary models for spatially structured tumors (Project Head Berg, Johannes )
• B07 - Predicting the constrained evolution of tumors (Project Head Beyer, Andreas )
• B08 - Predicting patterns of adaptation to radio-chemotherapy in cancer (Project Head Büttner, Reinhard )

• Applicant Institution: Universität zu Köln
• Participating Institution: Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI); Memorial Sloan Kettering Cancer Center
• Participating University: Heinrich-Heine-Universität Düsseldorf; Rheinische Friedrich-Wilhelms-Universität Bonn; Wageningen University; École Normale Supérieure - PSL
• Spokesperson: Professor Dr. Michael Lässig