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Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

Address Beutenbergstraße 11
07745 Jena
Deutschland

GERiT This institution in GERiT

07745 Jena

Projects

Research Grants
- Current projects
- Completed projects
Priority Programmes
- Current projects
  - Phase separation in PML nuclear bodies through a multivalent polySUMO-2/3 network is required for efficient DNA recombination and repair
    (Applicants Dittrich, Peter ; Hemmerich, Peter )
- Completed projects
Research Units
- Current projects
  - FOR 5228: Membrane trafficking processes underlying presynaptic proteostasis
    (Spokesperson Kreutz, Michael R. )
  - Presynaptic crosstalk of autophagy and proteasomal activity to maintain proteostasis
    (Applicants Eickholt, Britta ; Kirstein, Janine )
- Completed projects
  - Impact of heme and heme degradation products on peptides and proteins
    (Applicants Imhof, Ph.D., Diana ; Ohlenschläger, Oliver )
  - In vivo Charakterisierung verschiedener Spleißvarianten des Wilms Tumorsuppressorgens WT1
    (Applicant Englert, Christoph )
Independent Junior Research Groups
- Completed projects
  - Genetic and functional analysis of cirrhosis induced by telomere shortening
    (Applicant Rudolph, Karl Lenhard )
  - Homeostasis of satellite cells during aging
    (Applicant Freiin von Maltzahn, Julia )
Heisenberg Fellowships
- Completed projects
  - Biologie
    (Applicant Weih, Falk )
Clinical Research Units
- Completed projects
Heisenberg Professorships
- Completed projects
  - Untersuchungen zum Einfluß von Telomerfunktion und Seneszenz auf Stammzellfunktion, Organhomeostase und Regeneration
    (Applicant Rudolph, Karl Lenhard )
Science Communication, Research Data, eResearch
- Current projects
  - Open Access Publication Funding / 2024-2026 / Leibniz Institute on Aging - Fritz Lipmann Institute
    (Applicant Briest, Wilfried )
Collaborative Research Centres
- Current projects
  - Co-evolution of gut microbiota and immune cells during ageing in killifish
    (Project Heads Dönertas, Handan Melike ; Valenzano, Ph.D., Dario Riccardo )
  - Multicomponent nanoparticles for efficient targeting of inflammatory signaling and memory in hematopoietic stem and myeloid cells
    (Project Heads Rudolph, Karl Lenhard ; Träger, Anja )
  - SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
    (Spokesperson Schubert, Ulrich S. )
  - SFB 1310: Predictability in Evolution
    (Spokesperson Lässig, Michael )
- Completed projects
  - Activation of distinct NF-kB pathways through the lymphotoxin ß receptor
    (Project Head Weih, Falk )
  - Alternative Splicing as a Modulator of Signal Transduction
    (Project Heads Backofen, Rolf ; Platzer, Matthias )
  - Analyse der genomischen Grundlagen komplexer Reaktionsmuster von multifunktionellen Signalproteinen
    (Project Head Platzer, Matthias )
  - Analyse des Einflusses von Telomerdysfunktion auf das Environment und die Differenzierung hämatopoetischer Stammzellen
    (Project Head Rudolph, Karl Lenhard )
  - Analyse des Einflusses von Telomerdysfunktion auf die Regeneration und Stammzellfunktion im Pankreas
    (Project Head Rudolph, Karl Lenhard )
  - Analysis of alterations of micro- and macroenvironment of the stem cell niche caused by telomere dysfunction
    (Project Head Rudolph, Karl Lenhard )
  - Computersimulation der Bindung von Liganden an SH2-Domänen
    (Project Head Zacharias, Martin )
  - Crystal structure Determination of Proteins Related to Alzheimer`s Disease
    (Project Heads Bode, Wolfram ; Than, Manuel E. )
  - Crystal structure Determination of Proteins Related to Alzheimer`s Disease
    (Project Head Than, Manuel E. )
  - Eya1 as a switch between signal transduction and transcription
    (Project Head Englert, Christoph )
  - Quality control of gamma-secretase assembly in the endoplasmic reticulum
    (Project Head Kaether, Christoph )
  - Quality control of gamma-secretase complex assembly in the endoplasmic reticulum
    (Project Head Kaether, Christoph )
  - Regulation of DNA polymerase alpha, Cdc45 and TopBP1 at the initiation step of DNA replication
    (Project Heads Große, Frank ; Hänel, Frank )
  - Regulation of the tumour suppressor protein merlin
    (Project Heads Herrlich, Peter ; Morrison, Helen )
  - SFB 604: Multifunctional signaling proteins
    (Spokesperson Wetzker, Reinhard )
  - Strukturaufklärung multimerer Proteinkomplexe durch Röntgenstrukturanalyse
    (Project Head Hilgenfeld, Rolf )
  - Struktur-/Funktionsaufklärung und Optimierung von Nitratreduktasen
    (Project Heads Diekmann, Stephan ; Steinrücke, Peter )
  - Virulenzfaktoren intrazellulärer Pathogene und Signaltransduktion in der infizierten Wirtszelle; Mechanismen und Struturen multifunktioneller Komplexe von Mip-Proteinen mit Naturstoffen und Wirtszell-Proteinen
    (Project Head Hilgenfeld, Rolf )
Research Fellowships
- Completed projects
Major Research Instrumentation
- Completed projects
Major Instrumentation Initiatives
- Current projects
  - Minflux-Jena – advancing single-molecule detection in cell-biological research
Research Training Groups
- Current projects
  - GRK 2155: ProMoAge - Protein Modification: A Key Mechanism for Ageing
    (Spokesperson Simm, Andreas )
- Completed projects
  - GRK 639: The Molecular and Structural Basis of Tumorinstability
    (Spokespersons Gessler, Manfred ; Müller-Hermelink, Hans-Konrad )
  - GRK 768: Biomolecular Switches ? Coding of Proteins via Conformational Changes and Posttranslational Modifications
    (Spokesperson Heinemann, Stefan H. )
  - GRK 1041: Molecular Diabetology and Endocrinology in Clinical Medicine
    (Spokesperson Böhm, Bernhard Otto )
  - GRK 1715: Molecular Signatures of Adaptive Stress Responses
    (Spokespersons Heinzel, Thorsten ; Wetzker, Reinhard )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2030: CECAD - Excellent in Aging Research
    (Spokespersons Benzing, Thomas ; Hoppe, Thorsten ; Niessen, Ph.D., Carien )
Graduate Schools
- Completed projects
  - GSC 270: International Graduate School in Molecular Medicine Ulm
    (Spokesperson Kühl, Michael )
NFDI technical and methodological consortia
- Current projects
  - NFDI4Microbiota - National Research Data Infrastructure for Microbiota Research
    (Spokesperson Förstner, Konrad )

Subinstitutions

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