SFB 492:
Extracellular Matrix: Biogenesis, Assembly and Cellular Interactions
Subject Area
Biology
Medicine
Term
from 2000 to 2011
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5483940
The plethora of extracellular matrix functions can only be explained on the basis of structural features of supramolecular matrix aggregates. This central hypothesis defines the research directions of the collaborative research centre 492. Therefore, one of the major goals is the study of unique structural features of basically diverging matrix suprastructures, e.g. cartilage fibrils, type I-collagen containing fibrils, microfibrils, or anchoring fibrils. On this structural basis, the role of the extracellular matrices for cell adhesion, cell migration and differentiation is investigated.
Special emphasis is given to interactions of individual cells like antigen presenting cells and bacteria to matrix suprastructures. In addition, organ-specific matrix organzation forms will be addressed.
The experimental approaches will include the combined use of biophysical, genetic, biochemical, and immunological methods as well as by ultrastructural studies on the macromolecular level.
DFG Programme
Collaborative Research Centres
Completed projects
-
A02 - Suprastructure of the Extracellular Matrix: Macromolecular Alloys and Networks
(Project Head
Bruckner, Peter
)
-
A3 - Biologie und Pathobiologie der Verankerungsfibrillen der Haut
(Project Head
Bruckner-Tuderman, Leena Kaarina
)
-
A4 - Die proteolytische Konversion von Profibrillin zu Fibrillin und ihre Modulation: Rolle bei der Bildung elastischer Mikrofribrillen
(Project Head
Raghunath, Ph.D., Michael
)
-
A5 - Struktur und Funktion der Prokollagen C-Proteinase (BMP1)
(Project Head
Stöcker, Walter
)
-
A6 - Struktur, Stoffwechsel und Interaktionen von Dermatansulfat-Proteoglykanen der extrazellulären Matrix
(Project Head
Kresse, Hans
)
-
A7 - Internalisierung von Proteinen der extrazellulären Matrix zur Regulation ihrer extrazellulären Konzentration und biologischen Aktivität
(Project Head
Gerke, Volker
)
-
A8 - Studien zur Komposition und supramolekularen Interaktion von Kollagen XVI-positiven Fibrillen
(Project Head
Grässel, Susanne
)
-
A9 - Biogenese und pathogenetische Bedeutung kleiner leucinreicher Proteoglycane
(Project Head
Seidler, Daniela G.
)
-
A10 - The Role of ESAM and CD99 in Leukocyte Transmigration through Endothelium and Basement Membrane
(Project Head
Vestweber, Dietmar
)
-
A11 - Inhibition of Hyaluronan Export
(Project Head
Prehm, Peter
)
-
A12 - Bedeutung des pyrophosphatgenerierenden Enzyms ENPP1 als Modulator vaskulärer Mineralisationsprozesse
(Project Heads
Plenz, Gabriele
;
Rutsch, Frank
)
-
A13 - Die Rolle des Matrixproteinvon Willebrand-Faktor beiTumorzelladhäsion, -migration und -invasion
(Project Head
Schneider, Stefan Werner
)
-
A14 - Structural and Functional Characterisation of the Extracellular Matrix of the Spleen
(Project Head
Sorokin, Lydia
)
-
A16 - LG/LNS Domains as Mediators of Interactions between Synaptic Cell-Surface Proteins and L-Dystroglycan/ECM in the Brain
(Project Head
Missler, Markus
)
-
A17 - Integrin Signalling via the LIM-only Protein FHL2 and its Role in Lung and Skin Fibrosis
(Project Head
Wixler, Ph.D., Viktor
)
-
B2 - Interaktionen von dendritischen Antigen-präsentierenden Zellen mit Komponenten der extrazellulären Matrix bei Migration und Antigenpräsentation
(Project Head
Grabbe, Stephan
)
-
B03 - Zelluläre Wechselwirkungen mit Laminin-5: Von der Integrinerkennung zur zellbiologischen Funktion
(Project Head
Eble, Johannes Andreas
)
-
B4 - Einfluß der extrazellulären Matrix auf die Differenzierung des Endothels und des Epithels der Blut-Hirn-Schranken
(Project Head
Galla, Hans Joachim
)
-
B5 - Slit und Integrin vermittelte Signale bei der Bildung der Kommissuren im embryonalen ZNS von Drosophila
(Project Head
Klämbt, Christian
)
-
B09 - Adhesive Interactions between Staphylococcus aureus and Matrix-Suprastructures as Determinants of Invasive Infections: the Role of Eap and Emp
(Project Heads
Bruckner, Peter
;
Löffler, Bettina
;
Peters, Georg
)
-
B10 - Pathogenetische Bedeutung der kleinen, leucinreichen Proteoglycane Decorin und Biglycan bei diabetischer Nephropathie
(Project Heads
Schaefer, Roland M.
;
Schaefer, Liliana
)
-
B12 - Analyse der Funktion von Syndecan-4 und extrazellulärer Matrixkomponenten bei der Wundheilung
(Project Head
Echtermeyer, Frank
)
-
B13 - Interaction of Proteinase-Activated Receptors with the Extracellular Matrix in Malignant Melanoma
(Project Head
Steinhoff, Martin
)
-
B14 - Molekulare Analyse der Funktion der extrazellulären Matrix für die Steuerung der Navigation durch das chemorepulsive Signal Semaphorin 3A
(Project Head
Püschel, Andreas
)
-
B15 - Roles of Heparan Sulfate in Sonic Hedgehog (Shh) Gradient Formation and Cardiac Development in the Mouse
(Project Head
Grobe, Kay
)
-
B17 - Coupling Integrin Activation to the Actin Cytoskeleton
(Project Heads
Bogdan, Sven
;
Klämbt, Christian
)
-
B18 - Environmental Control of Chondrocyte Differentiation in Endochondral Ossification and Degenerative Joint Diseases
(Project Head
Dreier, Rita
)
-
B19 - Regulation of Fibroblast Attachment and Invasiveness by PI3KGamma-Mediated Signalling Pathways in Rheumatoid Arthritis
(Project Head
Pap, Thomas
)
-
B20 - Regulation of Mural Cell Function in the Cardiovascular System by Integrins and Integrin-Associated Molecules
(Project Head
Adams, Ralf H.
)
-
Z01 - Central Administration
(Project Head
Bruckner, Peter
)
-
Z02 - Characterization and Quantification of Proteins, Glycoproteins and Proteoglycans from Extracellular Matrix by Mass Spectrometry-Based Proteomics and Glycomics
(Project Head
Mormann, Michael
)
-
Z03 - Imaging Techniques
(Project Head
Robenek, Horst
)
