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Heinrich-Heine-Universität Düsseldorf
Institut für Biochemie
Lehrstuhl für Biochemie I

Address Universitätsstraße 1
40225 Düsseldorf
Deutschland

GERiT This institution in GERiT

40225 Düsseldorf

Projects

Research Grants
- Current projects
- Completed projects
  - Analyse der molekularen Dynamik der Nukleotid-bindenden Domäne des ABC-Transporters HlyB mittels NMR
    (Applicants Dötsch, Volker ; Schmitt, Lutz )
  - Auswirkungen mitochondrialer Dysfunktion in hämatopoietischen Zellen: Störung des Energie- und Eisenstoffwechsels und Entstehung genetischer Instabilität
    (Applicant Gattermann, Norbert )
  - Funktion des scERV1 und des homologen huALR Gens für die Aktivität und Biogenese der Mitochondrien in Hefe und menschlichen Zellen
    (Applicant Hofhaus, Götz )
  - Inhibitoren der Peptidyl-Prolyl-cis/trans-lsomerase auf der Basis von Übergangszustandsanaloga
    (Applicant Braun, Manfred )
  - Maturation and secretion of nisin A from Lactococcus lactis
    (Applicant Schmitt, Lutz )
  - Maturation and secretion of nisin A from Lactococcus lactis
    (Applicant Schmitt, Lutz )
  - Membrane protein folding in the crowded environment
    (Applicant Kedrov, Alexej A. )
  - Molekulare Mechanismen tierischer Anpassung
    (Applicant Grieshaber, Manfred K. )
  - Molekulare Struktur des mitochondrialen Atmungsketten-Komplex I
    (Applicant Weiss, Hanns )
  - Neurospora Genomprojekt
    (Applicant Schulte, Ulrich )
  - Photoaktivierbare Proteine
    (Applicant Schmitt, Lutz )
  - Single-molecule functional analysis of the yeast ABC-transporter Pdr5p
    (Applicants Schmitt, Lutz ; Volkmer, Andreas )
  - Structural and functional principles of low potassium signaling and the integration of nutrient sensing and adaptation in Arabidopsis
    (Applicants Kudla, Jörg ; Schmitt, Lutz )
  - Struktur und Evolution der Opindehydrogenasen
    (Applicant Grieshaber, Manfred K. )
  - Systemische und molekulare Mechanismen tierischer Anpassung
    (Applicant Grieshaber, Manfred K. )
Emmy Noether Independent Junior Research Groups
- Completed projects
  - Struktur, Dynamik und Funktion von ABC-Transportern
    (Applicant Schmitt, Lutz )
Priority Programmes
- Completed projects
  - Molecular interaction and high-resolution X-ray structures of the subunits of the osmoregulated ABC-transporter OpuA from B. subtillis
    (Applicant Schmitt, Lutz )
Heisenberg Fellowships
- Completed projects
  - Biochemie
    (Applicant Schmitt, Lutz )
Clinical Research Units
- Completed projects
  - Quantitative Struktur-Aktivitätsanalysen hepatobiliärer Transport-Systeme und deren pharmakologische Relevanz
    (Applicant Schmitt, Lutz )
Collaborative Research Centres
- Current projects
  - Links between mitochondrial energy metabolism and intracellular stress response pathways
    (Project Heads Reichert, Andreas ; Schmitt, Lutz )
  - Sensors for monitoring microbial metabolism and its regulation: structural and imaging approaches
    (Project Heads Frommer, Wolf-Bernd ; Smits, Sander ; Weidtkamp-Peters, Stefanie )
- Completed projects
  - Bedeutung des ALR-Proteins bei der Leberregeneration
    (Project Heads Hofhaus, Götz ; Lisowsky, Thomas )
  - Central Tasks
    (Project Head Schmitt, Lutz )
  - Interaction network and regulation of the human ABC transporter MDR3
    (Project Head Schmitt, Lutz )
  - In vitro characterization of ABC-transporters in human liver
    (Project Head Schmitt, Lutz )
  - Membrane translocation and chaperone-dependent folding of the lipase A of Pseudomonas aeruginosa
    (Project Head Kedrov, Alexej A. )
  - Protein Transport Across Biological Membranes - the HlyB/HlyA System from E.coli
    (Project Head Schmitt, Lutz )
  - SFB 1208: Identity and Dynamics of Membrane Systems - from Molecules to Cellular Functions
    (Spokesperson Schmitt, Lutz )
  - The hemolysin A secretion machinery from E. coli
    (Project Head Schmitt, Lutz )
Major Research Instrumentation
- Completed projects
Core Facilities
- Completed projects
  - Center for Structural Studies
Further Instrumentation Related Funding
- Current projects
  - Sustainable Remote Access to Chromatography-Coupled SAXS at Synchrotron Radiation Sources
    (Applicants Blanchet, Ph.D., Clement ; Smits, Sander )
Major Instrumentation Initiatives
- Completed projects
  - DNP-enhanced solid-state NMR spectroscopy
    (Applicant Heise, Henrike )
Research Training Groups
- Completed projects
  - GRK 57: Molecular Physiology: Metabolism and Energy Transformation
    (Spokesperson Grieshaber, Manfred K. )
  - GRK 320: Pathological Processes of the Nervous System: From Gene to Behavior
    (Spokesperson Reifenberger, Ph.D., Guido )
  - GRK 541: Protein Function at the Atomic Level
    (Spokesperson Buckel, Wolfgang )
  - GRK 2158: Natural products and natural product analogs against therapy-resistant tumors and microorganisms: new lead structures and modes of action
    (Spokesperson Gohlke, Holger )
Clusters of Excellence
- Completed projects
  - EXC 1028: Cluster of Excellence on Plant Sciences (CEPLAS) - From Complex Traits towards Synthetic Modules
    (Spokesperson Weber, Andreas P.M. )

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