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Institution
Universitätsklinikum Köln
Department of Translational Genomics
Address
Weyertal 115b
50931 Köln
Deutschland
GERiT
This institution in GERiT
50931 Köln
Projects
Research Grants
Current projects
Targeting inflammatory cell death pathways in squamous cell head and neck carcinomas to improve anti-tumor immunity
(Applicant
Brägelmann, Johannes
)
Understanding cancer-autonomous versus systemic mechanisms of KRAS-induced necroptotic priming
(Applicant
von Karstedt, Silvia
)
Understanding tumor progression and therapy resistance in Head and Neck Squamous Cell Carcinomas
(Applicants
Abedpour, Ph.D., Nima
;
George, Julie
)
Completed projects
Ein Chemical-Genomics Ansatz für die Identifizierung von Onkogenabhängigkeit beim kleinzelligen Bronchialkarzinom
(Applicant
Thomas, Roman
)
Esophageal adenocarcinoma: understanding the molecular basis of differential treatment response
(Applicants
Alakus, Hakan
;
Hillmer, Axel
;
Peifer, Martin
)
High-resolution analysis of structural genomic alterations in neuroblastoma by linked-read whole-genome sequencing
(Applicants
Bartenhagen, Christoph
;
Fischer, Matthias
)
Targeting ferroptosis pathway vulnerability in small cell lung cancer (SCLC)
(Applicant
von Karstedt, Silvia
)
Understanding mechanisms of drug resistance and clonal evolution in diffuse large B cell lymphoma
(Applicant
Reinhardt, Christian
)
Priority Programmes
Current projects
cPLA2α-mediated ferroptosis regulation in small cell lung cancer (SCLC)
(Applicant
von Karstedt, Silvia
)
Clinical Research Units
Completed projects
Central diagnostics, genomics and biobanking
(Applicants
Herling, Carmen Diana
;
Kreuzer, Karl-Anton
;
Peifer, Martin
)
KFO 286: Exploiting Defects in the DNA Damage Response for the Treatment of Chronic Lymphocytic Leukemia
(Spokesperson
Hallek, Michael
)
Collaborative Research Centres
Current projects
A translational platform for longitudinal molecular studies of SCLC under therapy
(Project Heads
Höpker, Katja
;
Lang, Ulrich
;
Peifer, Martin
;
Wesner, Stefan
;
Wolf, Jürgen
)
Bioinformatics and Data management
(Project Heads
Abedpour, Ph.D., Nima
;
Peifer, Martin
;
Valencia-Schneider, Monica
)
Bioinformatics, Research-Data Management, IT Infrastructure and Optimization
(Project Heads
Peifer, Martin
;
Schenk, Jasmin
;
Wesner, Stefan
)
Cell Death Assessment Unit
(Project Heads
Fritsch, Melanie
;
von Karstedt, Silvia
;
Kashkar, Hamid
)
Central administration
(Project Head
Thomas, Roman
)
Clonal evolution of SCLC
(Project Head
Peifer, Martin
)
How cell death shapes tumor evolution during carcinogenesis
(Project Heads
Berg, Johannes
;
von Karstedt, Silvia
)
Identification and characterization of molecular vulnerabilities in SCLC
(Project Heads
Beleggia, Filippo
;
Reinhardt, Christian
;
Wunderlich, Frank Thomas
)
Immuno-editing via programmed cell death in SCLC
(Project Head
von Karstedt, Silvia
)
Inflammatory signalling in ferroptotic cell death
(Project Head
von Karstedt, Silvia
)
Mechanisms of drug sensitivity and resistance in SCLC
(Project Heads
George, Julie
;
Thomas, Roman
)
Modeling the clonal evolution of high-risk CLL
(Project Heads
Fischer, Kirsten
;
Peifer, Martin
)
Molecular characterization of the immunogenic profile in SCLC tumors
(Project Head
George, Julie
)
Research data management, analysis and bioinformatics support
(Project Heads
Hofmann, Kay
;
von Karstedt, Silvia
;
Wesner, Stefan
)
SCLC response to chemotherapy and ionizing 𝛾-radiation
(Project Head
Cartolano, Maria
)
SFB 1399: Mechanisms of drug sensitivity and resistance in small cell lung cancer
(Spokesperson
Thomas, Roman
)
The role of ferroptosis in diffuse large B-cell lymphoma subtypes
(Project Head
von Karstedt, Silvia
)
Tracing clonal evolution in neuroblastoma by single-cell DNA sequencing
(Project Heads
Fischer, Matthias
;
Peifer, Martin
)
Completed projects
Validating therapeutic anti-angiogenic targets by a combined chemical genetics and imaging approach
(Project Heads
Thomas, Roman
;
Ullrich, Roland Tillmann
;
Wolf, Jürgen
)
International Research Training Groups
Current projects
GRK 3110: Tumor Heterogeneity and Genomic Instability in Lung Cancer – From Basic Mechanisms to Clinical Implications
(Spokesperson
Büttner, Reinhard
)
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