Universitätsklinikum Hamburg-Eppendorf
Zentrum für Diagnostik
Institut für Medizinische Mikrobiologie, Virologie und Hygiene
Address
Martinistraße 52
20251 Hamburg
Deutschland
GERiT
This institution in GERiT
20251 Hamburg
Projects
Priority Programmes
Current projects
Function of Small basic protein (Sbp) in Staphylococcus epidermidis biofilm matrix assembly: molecular mechanisms and spatio-temporal patterning.
(Applicant
Rohde, Holger
)
Completed projects
Crosstalk between Signaling Processes of Innate Immunity and Yersinia YopP Effector Functions
(Applicant
Ruckdeschel, Klaus
)
Function of the actin-activated Yersinia kinase YopO
(Applicant
Aepfelbacher, Martin
)
Funktion und zytoskeletale Zielproteine des kleinen G-Proteins CDC42Hs in menschlichen Monozyten und Blutplättchen
(Applicant
Aepfelbacher, Martin
)
Macrophage podosomes as integrative models for formin- and Arp2/3-based actin nucleation
(Applicant
Linder, Stefan
)
Mechanismen der Biofilmbildung von Staphylococcus epidermidis
(Applicant
Mack, Dietrich
)
Regulation dynamischer Adhäsionsstrukturen durch das CDC42Hs-Effektorprotein WASp in menschlichen Makrophagen
(Applicant
Aepfelbacher, Martin
)
Rolle des Zytoskeletts bei der Endothel-Infektion durch S. aureus
(Applicant
Aepfelbacher, Martin
)
Research Fellowships
Completed projects
"NES" vermittelter Proteinexport in der Hefe Saccharomyces cerevisiae
(Applicant
Fischer, Nicole Brigitte
)
Research Grants
Current projects
iDfellows: Hamburg Clinician Scientist Programme in Infectious Diseases
(Applicant
Lohse, Ansgar W.
)
Regulation of podosome dynamics and function by the podosome cap and base
(Applicant
Linder, Stefan
)
Completed projects
Deregulation of Toll-like receptor-controlled life and death signals by Yersinia
(Applicant
Ruckdeschel, Klaus
)
Drebrin as a regulator of endothelial cell-cell and cell-matrix contact
(Applicant
Linder, Stefan
)
Function of the Yersinia virulence factor YopM
(Applicant
Hentschke, Moritz
)
Intracellular processing of Borrelia burgdorferi in human macrophages
(Applicant
Linder, Stefan
)
Mechanotransduction at podosomes
(Applicant
Linder, Stefan
)
Molecular basis of giant Extracellular Matrix Binding Protein (Embp) mediated Staphylococcus epidermidis adherence to fibronectin and biofilm accumulation on artificial surfaces
(Applicant
Rohde, Holger
)
Molecular mechanisms of podosome dynamics and macrophage invasion
(Applicant
Linder, Stefan
)
Monitoring the emergence and origin of SARS-CoV-2 mutations – Genetic Inter- and Intrahost SARS-CoV-2 diversity in immunocompetent and immunocompromised patients
(Applicants
Aepfelbacher, Martin
;
Fischer, Nicole Brigitte
;
Grundhoff, Adam
)
Ökologie der Resistenz gegen quaternäre Ammoniumverbindungen bei klinischen Isolaten gram-negativer Species: Charakterisierung der funktionellen und genetischen Resistenzmechanismen und deren mögliche Korrelation mit einer multiplen Antibiotikaresistenz
(Applicant
Kaulfers, Paul-Michael
)
Regulation von Rho-GTPasen durch Yersinia Adhäsine und translozierte Yersinia Effektoren in menschlichen Zellen
(Applicant
Aepfelbacher, Martin
)
Targeting of autophagy by Yersinia enterocolitica
(Applicant
Ruckdeschel, Klaus
)
Transport of cell adhesion molecules: How does Rab21 organise integrin trafficking on a mechanistic level?
(Applicant
Aepfelbacher, Martin
)
Untersuchung zur Funktion des Accumulation associated proteins (Aap) bei der Staphylococcus epidermidis Biofilmbildung
(Applicant
Rohde, Holger
)
Yersinia-induced deregulation of cellular life and death signals in macrophages
(Applicants
Ruckdeschel, Klaus
;
Tholey, Andreas
)
Yersinien-induzierte Apoptose und TNFalpha-Suppression: Analyse der zellulären Mechanismen
(Applicant
Ruckdeschel, Klaus
)
Research Units
Current projects
FOR 5200: Disrupt - Evade - Exploit: Gene expression and host response programming in DNA virus infection (DEEP-DV)
(Spokesperson
Brinkmann, Melanie
)
Shaping of viral gene expression and replication patterns by host responses during early infection with human polyomaviruses
(Applicant
Fischer, Nicole Brigitte
)
Collaborative Research Centres
Current projects
Integrating mass spectrometry, network and structure modelling to study virus-host interactions in Arenaviruses
(Project Heads
Topf, Ph.D., Maya
;
Uetrecht, Charlotte
)
Metagenomics in emerging viral infections – integrating non-host and host transcriptional responses
(Project Head
Fischer, Nicole Brigitte
)
Targeting the ADPR-binding macrodomain associated deMARylation/dePARylation enzyme activity as novel approach towards SARS-CoV-2
(Project Heads
Fliegert, Ralf
;
Meier, Chris
;
Pfefferle, Susanne
)
Completed projects
Regulation of matrix metalloprotease activity during proteolytic invasion of human macrophages
(Project Head
Linder, Stefan
)
Struktur und Funktion des interzellulären Polysaccharid-Adhäsins (PIA) in Staphylokokken-Biofilmen
(Project Head
Rohde, Holger
)
Zytoskelett-Dynamik in Adhäsionsstrukturen humaner Makrophagen
(Project Heads
Aepfelbacher, Martin
;
Linder, Stefan
)
Major Research Instrumentation
Completed projects
3D STED-Mikroskop
Advanced confocal laser scan system for imaging fixed and living biological samples
Konfokales Laserscanning Mikroskopie System
Konfokales Mikroskop
SpinningDisk-TIRF Mikroskop
Major Instrumentation Initiatives
Completed projects
Analysis of highly dynamic subcellular mechanisms by Lattice Light Sheet Microscopy
Research Training Groups
Current projects
GRK 2771: Humans and Microbes: Reorganisation of Cell Compartments and Molecular Complexes during Infection
(Spokesperson
Aepfelbacher, Martin
)
GRK 2887: VISualization and structure in virus infectION (VISION)
(Spokesperson
Krey, Thomas
)
Completed projects
GRK 303: Infection and Immunity
(Spokesperson
Heesemann, Jürgen
)
GRK 438: Vascular Biology in Medicine
(Spokesperson
Siess, Wolfgang
)
GRK 1459: Sorting and Interactions Between Proteins of Subcellular Compartments
(Spokesperson
Braulke, Thomas
)
