Project Details
Projekt
FOR 784: Signalling by Fatty Acid Metabolites and Sphingolipids
Subject Area
Medicine
Term
from 2006 to 2013
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 26333961
Biology and medicine have entered a new area, in which the wealth of genomic, proteomic and small-molecule data provide new means to approach the analysis of molecules that so far have not been in the focus of research. New technologies are allowing investigators to more comprehensively identify missing pieces of complex biological questions.
Increasingly, lipids are recognized as important participants in the regulation and control of cell physiology and pathophysiology. Lipids are linked to such fundamental physiological processes as bioenergetics, cellular recognition and signal transduction across cells and cellular compartments.
The diversity of their chemical structure requires a truly comprehensive lipidomics approach that comprises multiple separation and identification techniques.
The Research Unit has established a platform that aims to characterise the lipid molecular species derived from fatty acids and sphingolipids and their specific biological roles, the expression of related enzymes and functional proteins, and the actions on gene expression. Finally, this may provide novel therapeutic approaches for the treatment of diseases.
Increasingly, lipids are recognized as important participants in the regulation and control of cell physiology and pathophysiology. Lipids are linked to such fundamental physiological processes as bioenergetics, cellular recognition and signal transduction across cells and cellular compartments.
The diversity of their chemical structure requires a truly comprehensive lipidomics approach that comprises multiple separation and identification techniques.
The Research Unit has established a platform that aims to characterise the lipid molecular species derived from fatty acids and sphingolipids and their specific biological roles, the expression of related enzymes and functional proteins, and the actions on gene expression. Finally, this may provide novel therapeutic approaches for the treatment of diseases.
DFG Programme
Research Units
International Connection
Switzerland
Projects
- Crosstalk von Sphingolipiden, Prostanoiden und Endocannabinoiden bei der Nozizeption (Applicant Scholich, Klaus )
- Die Funktion der C2 Domäne der 5-Lipoxygenase bei der Regulation der Enzymaktivität (Applicant Steinhilber, Dieter )
- Die Regulation des Ceramid/Sphingosin-1-Phosphat-Gleichgewichts durch Ceramidasen und Sphingosinkinasen in Nierenzellen und deren Bedeutung für Entzündungs- und Firbroseprozesse (Applicant Pfeilschifter, Josef M. )
- Die Rolle der verschiedenen Sphingosin 1-Phosphat (S1P) Rezeptorsubtypen bei Entzündungsprozessen in vitro und in vivo bei entzündlichen Nierenerkrankungen (Applicant Huwiler, Andrea )
- Die Rolle von Ceramidsynthasen in der Brustkrebs-Kanzerogene (Applicant Grösch, Sabine )
- Einfluss bioaktiver Lipide aus apoptotischen Zellen auf den Makrophagenphänotyp (Applicant Brüne, Bernhard )
- Gewebespezifische Funktionen der löslichen Epoxihydrolase in vaskulären Schädigungsmodellen (Applicant Brandes, Ralf P. )
- "Peroxisome proliferator-activated receptors" (PPARs) als Vermittler zwischen Sphingolipid- und Eicosanoid-Signalwegen (Applicant Koch, Alexander )
- Quantifizierung von Lipidmediatoren mittels Tandem-Massenspektrometrie (Applicant Geißlinger, Gerd )
- Regulation der Ca2+-Homöostase durch Enzyme des Sphingosin-1-Phosphat-Metabolismus (Applicant Meyer zu Heringdorf, Dagmar )
- Zentralprojekt (Applicant Pfeilschifter, Josef M. )
Spokesperson
Professor Dr. Josef M. Pfeilschifter
