Project Details
Projekt
EXC 257: NeuroCure - Towards a Better Outcome of Neurological Disorders
Subject Area
Neurosciences
Term
from 2007 to 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 39052203
Neurological disorders contribute to more than 35 percent of overall disease burden in Germany, and with an aging society, this number will be increasing further. Recently major advances have been made in understanding the pathophysiologicial processes underlying such disorders, thereby promising new avenues of intervention that could eventually lead to cure. The cluster of excellence NeuroCure will serve as an interdisciplinary consortium and unites neuroscientists, basic researchers and clinicians alike on one campus, independent of their current institutions.
NeuroCure will be committed to a strong translational research approach. Due to the wealth of knowledge and success of Berlin based neuroscientists working in the areas of cerebrovascular diseases, neuroinflammation and disorders of network formation, the initial focus is on stroke, multiple sclerosis, as well as on focal epilepsies and CNS disturbances due to mitochondrial dysfunction. These neurological disorders are known to have overlapping pathophysiological cascades.
Building on innovative programmes for promoting early-stage scientists (e.g. the Graduate Programme "Medical Neurosciences") and established structures (e.g. the Neurowissenschaftliches Forschungszentrum) as well as core facilities (e.g. the Berlin NeuroImaging Center) for interdisciplinary research, the funding of NeuroCure will enable us:
(1) to establish intramural flexible funds to start-up interactive and innovative projects allocated according to outstanding scientific merit and monitored by peer-review,
(2) to set-up an animal research unit for long-term outcome and behavioural analysis,
(3) to found the NeuroCure Clinical Research Centre (NCRC), and
(4) to recruit complementing tenure-track faculty for key research areas such as mechanisms of brain damage, endogenous brain protection, regeneration, crosstalk between the nervous and immune system, developmental disturbances as well as developmental and experience dependent plasticity.
NeuroCure will be committed to a strong translational research approach. Due to the wealth of knowledge and success of Berlin based neuroscientists working in the areas of cerebrovascular diseases, neuroinflammation and disorders of network formation, the initial focus is on stroke, multiple sclerosis, as well as on focal epilepsies and CNS disturbances due to mitochondrial dysfunction. These neurological disorders are known to have overlapping pathophysiological cascades.
Building on innovative programmes for promoting early-stage scientists (e.g. the Graduate Programme "Medical Neurosciences") and established structures (e.g. the Neurowissenschaftliches Forschungszentrum) as well as core facilities (e.g. the Berlin NeuroImaging Center) for interdisciplinary research, the funding of NeuroCure will enable us:
(1) to establish intramural flexible funds to start-up interactive and innovative projects allocated according to outstanding scientific merit and monitored by peer-review,
(2) to set-up an animal research unit for long-term outcome and behavioural analysis,
(3) to found the NeuroCure Clinical Research Centre (NCRC), and
(4) to recruit complementing tenure-track faculty for key research areas such as mechanisms of brain damage, endogenous brain protection, regeneration, crosstalk between the nervous and immune system, developmental disturbances as well as developmental and experience dependent plasticity.
DFG Programme
Clusters of Excellence
Applicant Institution
Freie Universität Berlin; Humboldt-Universität zu Berlin
Participating Institution
Charité - Universitätsmedizin Berlin; Deutsches Rheuma-Forschungszentrum Berlin (DRFZ); Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
im Forschungsverbund Berlin e.V.; Max-Delbrück-Centrum für Molekulare Medizin (MDC)
im Forschungsverbund Berlin e.V.; Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Spokesperson
Professor Dr. Dietmar Schmitz
Participating Researchers
Professorin Dr. Carmen Birchmeier; Professor Dr. Michael Brecht; Professor Dr. Ulrich Dirnagl; Professor Dr. Matthias Endres; Professorin Dr. Annette Grüters-Kieslich; Professor Volker Haucke, Ph.D.; Professor Dr. John-Dylan Haynes; Professor Dr. Andreas Heinz; Professor Dr. Frank Heppner; Professor Dr. Thomas J. Jentsch; Professor Dr. Helmut Kettenmann; Professor Dr. Peter Michael Kloetzel; Professorin Dr. Andrea Kühn; Professor Dr. Gary Richard Lewin, Ph.D.; Professor Dr. Gerhard Multhaup; Professor Dr. Josef Priller; Professor Dr. Andreas Radbruch; Professorin Constance Scharff, Ph.D.; Professor Dr. Christian M. T. Spahn; Professor Dr. Mathias Treier; Professor Dr. Peter Vajkoczy; Professor Dr. Arno Villringer; Professor Dr. Erich E. Wanker
