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Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
im Forschungsverbund Berlin e.V.

Address Robert-Rössle-Straße 10
13125 Berlin
Deutschland

GERiT This institution in GERiT

13125 Berlin

Projects

Research Units
- Current projects
  - Cell type-specific roles of lysosomal chloride/proton exchange
    (Applicants Jentsch, Thomas J. ; Stauber, Tobias )
  - FOR 2518: Functional dynamics of ion channels and transporters - DynIon -
    (Spokesperson Benndorf, Klaus )
  - FOR 2625: Mechanisms of Lysosomal Homeostasis
    (Spokesperson Braulke, Thomas )
  - FOR 5228: Membrane trafficking processes underlying presynaptic proteostasis
    (Spokesperson Kreutz, Michael R. )
  - Ion Permeation in Potassium Selective and Non-selective Cation Channels
    (Applicants Plested, Andrew ; Sun, Han )
  - Mechanism of regulation of lysosome biogenesis and function by cellular ion homeostasis
    (Applicant Haucke, Ph.D., Volker )
  - Molecular mechanism and function of neuronal ER-phagy
    (Applicants Haucke, Ph.D., Volker ; Kuijpers, Marijn )
- Completed projects
Research Grants
- Current projects
- Completed projects
Research Fellowships
- Completed projects
Priority Programmes
- Completed projects
Independent Junior Research Groups
- Completed projects
Reinhart Koselleck Projects
- Completed projects
  - Molecular mechanisms of presynaptic membrane recycling, turnover, and transport
    (Applicant Haucke, Ph.D., Volker )
Collaborative Research Centres
- Current projects
  - Atomic structure and conduction mechanism of viral proton channels in liposomes studied by solid-state NMR
    (Project Head Lange, Adam )
  - Fluorine-Specific Interactions for the Enhancement of Cellular Uptake of Proteins and Drug Conjugates into Living Cells
    (Project Head Hackenberger, Christian )
  - Proton exchange processes in phytochromes and retinal proteins investigated by MAS NMR
    (Project Heads Hegemann, Peter ; Oschkinat, Hartmut )
  - Proton permeation pathway and ion selectivity of viroporins investigated by atomistic molecular dynamics simulations
    (Project Head Sun, Han )
  - Role of mTORC1 and protein translation in memory consolidation in the neocortex
    (Project Heads Haucke, Ph.D., Volker ; Larkum, Matthew ; Mikhaylova, Marina )
  - Semi-synthetic approaches to probe mucin function
    (Project Heads Hackenberger, Christian ; Seitz, Oliver )
  - SFB 1078: Protonation Dynamics in Protein Function
    (Spokespersons Dau, Holger ; Heberle, Joachim )
  - SFB 1286: Quantitative Synaptology
    (Spokesperson Rizzoli, Ph.D., Silvio-Olivier )
  - SFB 1315: Mechanisms and disturbances in memory consolidation: From synapses to systems
    (Spokesperson Larkum, Matthew )
  - SFB 1349: Fluorine-Specific Interactions: Fundamentals and Functions
    (Spokesperson Hasenstab-Riedel, Sebastian )
  - SFB 1449: Dynamic Hydrogels at Biointerfaces
    (Spokesperson Haag, Rainer )
- Completed projects
  - Acid-activated Cl- channels in kidney function and protection
    (Project Head Jentsch, Thomas J. )
  - Bestimmung der Raumstrukturen von Rezeptoren sowie gebundener Agonisten und Antagonisten mittels Festkörper-NMR-Spektroskopie
    (Project Heads Oschkinat, Hartmut ; van Rossum, Barth-Jan )
  - Central Tasks-SFB Headquarters and Administration
    (Project Heads Haucke, Ph.D., Volker ; Sigrist, Stephan J. )
  - Charakterisierung der vesikulären Chloridkanäle CIC-3, CIC-4 und CIC-5
    (Project Head Jentsch, Thomas J. )
  - Die Rolle von Interleukin-2 bei Aktivierung und Proliferation von Lymphocyten
    (Project Head Horak, Ivan )
  - Einfluß von Astrozyten auf Gehirnendothelzellen bei Hypoxie
    (Project Head Blasig, Ingolf )
  - ER-Insertion und Qualitätskontrolle von G-Protein-gekoppelten Rezeptoren
    (Project Heads Rosenthal, Walter ; Schülein, Ralf )
  - Functional analysis of septin scaffolds assembled at the plasma membrane during cytokinesis
    (Project Heads Daumke, Oliver ; Ewers, Helge ; Krauß, Michael )
  - Functional organization and dynamics of PI-kinase-based modules for protein sorting at endosomal membranes
    (Project Heads Haucke, Ph.D., Volker ; Krauß, Michael )
  - Functional peptide- and protein conjugates for multivalent targeting in vitro and in vivo
    (Project Heads Budisa, Nediljko ; Hackenberger, Christian )
  - Funktionelle Analyse ausgewählter CLC Chloridkanäle mit transgenen Mausmodellen
    (Project Head Jentsch, Thomas J. )
  - Herstellung und Haltung genetisch veränderter Mäuse
    (Project Heads Horak, Ivan ; Rohde, Elvira )
  - Identification and characterization of a novel metazoan disaggregase module
    (Project Head Kirstein-Miles, Janine )
  - Integrated Research Training Group
    (Project Heads Ewers, Helge ; Knaus, Petra ; Krauß, Michael )
  - Interaktion von G-Protein-gekoppelten Rezeptoren mit dem Translokon der ER-Membran und Entwicklung neuer Überxpressionssysteme für integrale Membranproteine
    (Project Heads Rosenthal, Walter ; Schülein, Ralf )
  - Modulation of cytokine expression and cytokin mediated expression
    (Project Heads Frank, Ronald ; Nourbakhsh, Mahtab )
  - Modules involved in endosomal/lysosomal Ion homeostasis and function
    (Project Head Jentsch, Thomas J. )
  - Molekulare Mechanismen der Sortierungssignalerkennung und Membrandeformation
    (Project Head Haucke, Ph.D., Volker )
  - Multivalency in Chemistry and Biochemistry
    (Project Heads Hackenberger, Christian ; Paulus, Beate )
  - Multivalent interactions of WW and SH2 domains containing proteins
    (Project Heads Freund, Christian ; Oschkinat, Hartmut )
  - Multivalent modulation of clathrin-mediated endocytosis
    (Project Head Haucke, Ph.D., Volker )
  - NMR-spectroscopic investigation of light-induced structural changes in protein-chromophore complexes
    (Project Head Schmieder, Peter )
  - Orientierung von G-Protein-gekoppelten Rezeptoren in der ER-Membran von Säugerzellen
    (Project Heads Rosenthal, Walter ; Schülein, Ralf )
  - Proteomics platform for protein interaction mapping
    (Project Heads Freund, Christian ; Liu, Fan ; Multhaup, Gerhard ; Weise, Christoph )
  - Regulation der Biogenese synaptischer Vesikel
    (Project Head Haucke, Ph.D., Volker )
  - Regulation of SH3 domain-based scaffolds in clathrin-mediated endocytosis
    (Project Heads Freund, Christian ; Haucke, Ph.D., Volker )
  - Regulation signal-induzierter Membrantransportprozesse an chemischen Synapsen durch Proteine und Lipide
    (Project Head Haucke, Ph.D., Volker )
  - Role of volume-regulated anion channels (VRACs) in kidney integrity
    (Project Head Jentsch, Thomas J. )
  - SFB 366: Cellular Signal Recognition and Transduction
    (Spokesperson Reutter, Werner )
  - SFB 444: Basis of Neuronal Communication and signal transduction
    (Spokesperson Jentsch, Thomas J. )
  - SFB 449: Structure and Function of Membrane Integral Receptors
    (Spokesperson Haucke, Ph.D., Volker )
  - SFB 498: Protein-Cofactor Interactions in Biological Processes
    (Spokespersons Bittl, Robert ; Stehlik, Dietmar )
  - SFB 740: From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
    (Spokespersons Hofmann, Klaus Peter ; Spahn, Christian M. T. )
  - SFB 765: Multivalency as Chemical Organisation and Action Principle: New Architectures, Functions and Applications
    (Spokesperson Haag, Rainer )
  - SFB 958: Scaffolding of Membranes: Molecular Mechanisms and Cellular Functions
    (Spokespersons Haucke, Ph.D., Volker ; Sigrist, Stephan J. )
  - SFB 1365: Renoprotection
    (Spokesperson Persson, Pontus Börje )
  - Structural and dynamical studies of ß-strand-membrane proteins by liquid-/solid-state NMR spectroscopy
    (Project Heads Andreas, Loren ; Griesinger, Christian ; Lange, Adam ; Linser, Ph.D., Rasmus )
  - Structural and functional organization of endocytic scaffolds within the periactive zone
    (Project Heads Haucke, Ph.D., Volker ; Maritzen, Tanja )
  - Structural characterization of chaperone modulated protein aggregation in S. cervisiae
    (Project Head Reif, Bernd )
  - Structural investigations of modules involved in protein homeostasis
    (Project Heads Oschkinat, Hartmut ; van Rossum, Barth-Jan )
  - Strukturelle Analyse von BACE-Substrat Wechselwirkungen: APP-BACE und ABeta-BACE
    (Project Heads Multhaup, Gerhard ; Reif, Bernd )
  - Struktur und Funktion des Vasopressinsensitiven Wasserkanals der Niere
    (Project Head Rosenthal, Walter )
  - Struktur und Spezifität von Cytokin-Rezeptoren (IL-4Ra und IL-2Ry) und ihren niedermolekularen Antagonisten
    (Project Heads Müller, Thomas ; Oschkinat, Hartmut )
  - Strukturuntersuchungen an solubilisiertem Rhodopsin und funktionellen Komplexen mit der Flüssigphasen-NMR-Spektroskopie
    (Project Heads Hofmann, Klaus Peter ; Oschkinat, Hartmut )
  - Untersuchungen von CRF- und CRF-Rezeptor-Mutanten zur Entwicklung eines Modells für die Ligandenerkennung von G-Protein-gekoppelten Rezeptoren der Familie 2
    (Project Heads Beyermann, Michael ; Bienert, Michael ; Rosenthal, Walter )
  - Untersuchungen von Protein-Kofaktor-Wechselwirkungen mit der Festkörper- und Lösungs-NMR-Spektroskopie
    (Project Heads Oschkinat, Hartmut ; Schmieder, Peter )
  - Verwaltung des SFB
    (Project Head Jentsch, Thomas J. )
DIP Programme
- Completed projects
  - Dynamic Nuclear Polarization: Integrating fundamentals and new applications
    (Applicants Oschkinat, Hartmut ; Vega, Shimon )
Major Research Instrumentation
- Completed projects
  - STORM/PALM Super-Resolution Mikroskopie System
  - Structures Illumination Microscopy (SIM) System
CRC/Transregios
- Current projects
  - Molecular switches in the TGF-β signaling pathway – the role of inositol pyrophosphate messengers
    (Project Heads Fiedler, Dorothea ; Klingmüller, Ursula )
  - Phosphoinositide-based switches in endolysosomal membrane dynamics and signaling
    (Project Heads Haucke, Ph.D., Volker ; Schultz, Carsten )
- Completed projects
  - Molecular switches in polarized sorting and signaling in intestinal epithelial cells
    (Project Heads Boulant, Steeve ; Haucke, Ph.D., Volker )
Research Training Groups
- Current projects
- Completed projects
  - GRK 80: Model Studies of Structures, Properties and Recognition of Biologically Relevant Molecules at Atomic Level
    (Spokesperson Höhne, Wolfgang )
  - GRK 238: Mechanisms of Damage in CNS Disease - Application of Imaging Techniques
    (Spokesperson Heinemann, Uwe )
  - GRK 255: Signal Transduction in the Nervous System and its Pathology
    (Spokesperson Schachner, Melitta )
  - GRK 782: Spectroscopy and Dynamics of Molecular Aggregates, Chains, Coils and Networks
    (Spokesperson Suhm, Martin )
  - GRK 788: Hydrogen Bonding and Hydrogen Transfer
    (Spokesperson Limbach, Hans-Heinrich )
  - GRK 1123: Cellular Mechanisms of Learning and Memory Consolidation in the Hippocampal Formation
    (Spokesperson Schmitz, Dietmar )
Major Instrumentation Initiatives
- Completed projects
  - Lattice Light Sheet Microscope (LLSM)
Clusters of Excellence
- Completed projects
  - EXC 257: NeuroCure - Towards a Better Outcome of Neurological Disorders
    (Spokesperson Schmitz, Dietmar )
Graduate Schools
- Completed projects
  - GSC 1091: Berlin School of Integrative Oncology (BSIO)
    (Spokespersons Na, Il-Kang ; Schmitt, Clemens A. )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2008: UniSysCat
    (Spokespersons Dobbek, Holger ; Drieß, Matthias ; Mroginski, Maria Andrea ; Rappsilber, Juri ; Thomas, Arne )
  - EXC 2049: NeuroCure
    (Spokespersons Dirnagl, Ulrich ; Schmitz, Dietmar )

Subinstitutions

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