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Deutsches Rheuma-Forschungszentrum Berlin (DRFZ)

Address Charitéplatz 1
10117 Berlin
Deutschland

GERiT This institution in GERiT

10117 Berlin

Projects

Research Grants
- Current projects
  - Heterogeneity and Imprinting of Long-lived Plasma Cells
    (Applicant Chang, Hyun-Dong )
  - In situ single-cell metabolic profiling of the microbiota and its control by the immune system
    (Applicants Chang, Hyun-Dong ; Kruglov, Andrey A. )
- Completed projects
Reinhart Koselleck Projects
- Completed projects
  - Tetrazyklin- induzierbare, Proliferations- regulierende Gene zur Etablierung und Funktionsanalyse langzeitig wachsender hämatopoietischer Progenitorzelllinien
    (Applicant Melchers, Fritz )
Priority Programmes
- Completed projects
  - Delineation of human plasma cell subsets and their bone marrow niche
    (Applicant Dörner, Thomas )
  - Mesenchymal stroma cells as organizers of immunological memory in the bone marrow
    (Applicants Chang, Hyun-Dong ; Radbruch, Andreas )
Core Facilities
- Completed projects
  - GERMANET. the nationwide GERman MAss cytometry NETwork: project-specific supervision, exchange of expertise, technology transfer, data analysis
    (Applicant Mei, Henrik )
Collaborative Research Centres
- Current projects
  - SFB 1403: Cell Death in Immunity, Inflammation and Disease
    (Spokesperson Pasparakis, Manolis )
  - SFB 1454: Metaflammation and Cellular Programming
    (Spokespersons Latz, Eicke ; Wachten, Dagmar )
- Completed projects
  - Analysis of the presentation of orally applied antigens and the specific T cell reaction: tolerance versus immunity
    (Project Heads Radbruch, Andreas ; Scheffold, Alexander )
  - Analysis of tolerance induction of interleukin-17-producing T helper cells in the small intestine
    (Project Heads Esplugues, Ph.D., Enric ; Hauser, Anja Erika )
  - An integrated high-resolution immunophenotyping and computational biomarker discovery approach for monitoring clinical trials
    (Project Heads Grützkau, Ph.D., Andreas ; Häupl, Thomas ; Sawitzki, Birgit )
  - Antigene Spezifität der synovialen B-Zellen bei Patienten mit Rheumatoider Arthritis
    (Project Head Berek, Claudia )
  - Antigen-specific regulatory T-cells for cellular therapies
    (Project Heads Sieper, Joachim ; Thiel, Andreas )
  - Characterization of IL-10 producing B-lymphocytes
    (Project Head Fillatreau, Simon )
  - Engineering resting B cells for the suppression of unwanted immunity
    (Project Head Fillatreau, Simon )
  - Entwicklung und Durchführung von Technologien zur Antigen-spezifischen Zytomerie mittels Multiparamteranalyse
    (Project Head Scheffold, Alexander )
  - Exploiting NK cells for suppression of unwanted immune responses in transplantation
    (Project Heads Romagnani, Ph.D., Chiara ; Uharek, Lutz )
  - Funktion von Kohlenhydrat/Protein-Interaktionen für das Homing von Lymphozyten
    (Project Head Hamann, Alf )
  - Identification of T cell epitopes relevant for inflammatory bowel diseases and their rheumatic manifestations
    (Project Heads Duchmann, Rainer ; Sieper, Joachim ; Thiel, Andreas )
  - Immune modulation of allergic diseases by nuclear hormone receptor ligands
    (Project Heads Heine, Guido ; Radbruch, Andreas ; Worm, Margitta )
  - Induction of specific homing receptors and of regulatory properties in mucosal T cells
    (Project Heads Hamann, Alf ; Hühn, Jochen )
  - Induction of stable FOXP3+ regulatory T-cells
    (Project Head Hamann, Alf )
  - Induktion und Stabilisierung des IL-10 Gedächtnisses von Tr1-Zellen für zelluläre immunregulatorische Therapien
    (Project Heads Radbruch, Andreas ; Sieper, Joachim ; Thiel, Andreas )
  - Integrated Research Training Group IMMUCO
    (Project Heads Klugewitz, Katja ; Moos, Verena ; Radbruch, Andreas ; Zeitz, Martin )
  - Integration of signal transduction and cytokine expression in T helper lymphocytes
    (Project Heads Höfer, Thomas ; Löhning, Max ; Radbruch, Andreas )
  - Präparative Zellsortierung und Modifikation von regulatorischen Zellpopulationen
    (Project Heads Radbruch, Andreas ; Radtke, Hartmut ; Scheffold, Alexander )
  - Redirecting the antigen-specificity of polyclonal regulatory T cells to optimize their therapeutic efficacy and safety
    (Project Heads Fillatreau, Simon ; Scheffold, Alexander ; Uckert, Wolfgang )
  - Regulation und Funktion von Selektin-Liganden auf Lymphozyten
    (Project Head Hamann, Alf )
  - Regulatory T cell induction by manipulation of transcription factors
    (Project Head Baumgraß, Ria )
  - Rekrutierung von T-Zell-Subsets: Rolle von Antigen und Crosstalk mit Endothel
    (Project Heads Hamann, Alf ; Hühn, Jochen )
  - Role and potential therapeutic use of interleukin-22+ Natural Killer cells in colitis
    (Project Head Romagnani, Ph.D., Chiara )
  - SFB 421: Protective and Pathological Effects of Antigen Processing
    (Spokesperson Kloetzel, Peter Michael )
  - SFB 618: Theoretical Biology: Robustness, Modularity and Evolutionary Design of Living Systems
    (Spokesperson Hammerstein, Peter )
  - SFB 633: Induction and Modulation of T cell Mediated Immune Responses in the Gastrointestinal Tract
    (Spokespersons Siegmund, Britta ; Zeitz, Martin )
  - SFB 650: Cellular Approaches for the Suppression of Unwanted Immune Reactions - From Bench to Bedside
    (Spokesperson Volk, Hans-Dieter )
  - SFB 760: Biomechanics and Biology of Musculoskeletal Regeneration - From Functional Assessment to Guided Tissue Formation
    (Spokesperson Duda, Georg )
  - Significance of tumor necrosis factor and lymphotoxin signalling for mucosal immunity
    (Project Head Nedospasov, Sergei A. )
  - Stabilität und Plastizität der Expression von Zytokinen in T-Lymphozyten
    (Project Head Radbruch, Andreas )
  - Targeting of memory plasma cells in autoimmune diseases
    (Project Heads Burmester, Gerd-Rüdiger ; Hiepe, Falk ; Radbruch, Andreas )
  - Targeting of pathogenic T helper cells in chronic rheumatic inflammation
    (Project Heads Chang, Hyun-Dong ; Mashreghi, Mir-Farzin ; Radbruch, Andreas )
  - The role of AP-1 signalling in the pathology of bone remodelling
    (Project Head David, Ph.D., Jean-Pierre )
  - The role of proinflammatory T cells in chronic mucosal inflammation
    (Project Heads Chang, Hyun-Dong ; Radbruch, Andreas ; Thiel, Andreas )
Clinical Research Units
- Completed projects
  - Identifizierung von Signalen, die die Differenzierung und das Überleben von humanen Plasmazellen regulieren
    (Applicant Manz, Rudolf )
CRC/Transregios
- Current projects
  - Dissecting the role of epithelial inflammasome activation in regulating immune responses in colitis
    (Project Heads Chang, Hyun-Dong ; Radbruch, Andreas ; Ronchi, Francesca )
  - TRR 241: Immune-Epithelial Communication in Inflammatory Bowel Diseases
    (Spokesperson Becker, Christoph )
- Completed projects
  - B cells and beyond
    (Project Heads Jäck, Hans-Martin ; Melchers, Fritz ; Schuh, Wolfgang )
  - Binary Decision Making in Gene Expression Control of T Lymphocytes
    (Project Heads Baumgraß, Ria ; Radbruch, Andreas )
  - Deciphering the antibody-independent functions of antibody-producing cells in autoimmune diseases
    (Project Head Fillatreau, Simon )
  - Deciphering the survival code of memory plasma cells and memory B cells
    (Project Heads Chang, Hyun-Dong ; Mashreghi, Mir-Farzin ; Radbruch, Andreas )
  - Effector and regulatory CD4 T cells in tumor surveillance
    (Project Heads Fillatreau, Simon ; Romagnani, Ph.D., Chiara )
  - Epigenetic Control of the Transcription of Homing Receptors
    (Project Heads Hamann, Alf ; Syrbe, Uta )
  - Heterogeneity and Imprinting of Long-lived Plasma Cells
    (Project Heads Dörner, Thomas ; Mei, Henrik )
  - Regulation of Foxp3 Expression
    (Project Heads Hamann, Alf ; Hühn, Jochen )
  - Transcriptional Regulation of the Human and Mouse TNF/Lymphotoxin Locus in T Lymphocytes of Transgenic and Knock-in Mice
    (Project Head Nedospasov, Sergei A. )
  - TRR 36: Principles and Applications of Adoptive T Cell Therapy
    (Spokesperson Blankenstein, Thomas )
  - TRR 52: Transcriptional Programming of Individual T Cell Subsets
    (Spokesperson Schmitt, Edgar )
  - TRR 54: Growth and Survival, Plasticity and Cellular Interactivity of Lymphatic Malignancies
    (Spokesperson Dörken, Bernd )
  - TRR 130: B Cells: Immunity and Autoimmunity
    (Spokesperson Nitschke, Lars )
  - "Versatile memory T cells" for adoptive T Cell therapy - identification, characterisation and strategies for clinical applications
    (Project Heads Radbruch, Andreas ; Thiel, Andreas )
Research Fellowships
- Completed projects
  - Leukocytes as biosensors for clinical parameters, the effects of novel therapeutics and prediction of disease course in patients with SLE
    (Applicant Mei, Henrik )
New Instrumentation for Research
- Current projects
  - Development of a demonstrator for the label-free flow cytometry based on light scatter-driven pulse shapes
    (Applicants Chang, Hyun-Dong ; Kaiser, Toralf )
- Completed projects
  - Flow cytometric pulse form analysis and sorting for microbiota cytometry
    (Applicants Chang, Hyun-Dong ; Kaiser, Toralf )
Further Instrumentation Related Funding
- Current projects
  - The German Mass Cytometry Alliance
    (Applicants Baumgart, Sabine ; Bengsch, Ph.D., Bertram ; Chang, Hyun-Dong ; Kunkel, Désirée ; Mei, Henrik ; Warth, Sarah )
Research Training Groups
- Completed projects
  - GRK 1121: Genetic and Immunologic Determinants of Pathogen-Host-Interactions
    (Spokesperson Lucius, Richard )
Clusters of Excellence
- Completed projects
  - EXC 257: NeuroCure - Towards a Better Outcome of Neurological Disorders
    (Spokesperson Schmitz, Dietmar )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 3118: ImmunoPreCept: Exploring the Health-Disease Bifurcation for Cell-based Molecular Prevention and Interceptive Medicine
    (Spokespersons Diefenbach, Andreas ; Rajewsky, Nikolaus ; Siegmund, Britta )
Graduate Schools
- Completed projects
  - GSC 203: Berlin-Brandenburg School for Regenerative Therapies (BSRT)
    (Spokesperson Duda, Georg )
NFDI technical and methodological consortia
- Current projects
  - National Research Data Infrastructure for Immunology
    (Spokesperson Busse, Christian )

Subinstitutions

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