SFB 1525:  Cardio-Immune Interfaces

• Subject Area: Medicine ; Biology
• Term: since 2022
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Elucidating the role of monocyte – Treg interactions as key drivers of cardiovascular remodelling after myocardial infarction (Project Heads Kastenmüller, Wolfgang ;  Zernecke-Madsen, Alma )
• A02 - T cells as a therapeutic target in an acute myocardial infarction pig model (Project Heads Beyersdorf, Niklas ;  Frey, Anna )
• A03 - Pathomechanisms of Immunosenescence in the post-myocardial infarction healing response (Project Heads Gasteiger, Georg ;  Ramos, Ph.D., Gustavo C. )
• A04 - Cellular junctions: target structures for inflammation in arrhythmogenic cardiomyopathy and beyond (Project Heads Dölken, Lars ;  Gerull, Brenda )
• A05 - Role of lymphocytes for the progression of a genetically determined cardiomyopathy (Project Head Hofmann, Ulrich )
• A06 - Platelet impacts on recruitment, gene expression and functional capacities of innate immune cells post myocardial infarction (Project Heads Cochain, Ph.D., Clement ;  Nieswandt, Bernhard )
• A07 - Impact of ischemic cardiomyopathy on haematopoiesis (Project Head Stegner, David )
• B01 - Role of β2-adrenergic- and natriuretic peptide receptor- induced signalling in CD4+ T-cells after myocardial infarction (Project Heads Frantz, Stefan ;  Nikolaev, Viacheslav )
• B02 - ANP-mediated cardiomyocyte-endothelial cell cross-talk (wrong-talk?): role in ischemia/reperfusion-induced activation of immune cells (Project Head Kuhn, Michaela )
• B03 - Impact of nuclear ERK 1/2 signalling in inflammation-driven cardiovascular diseases (Project Heads Lorenz, Kristina ;  Zernecke-Madsen, Alma )
• B04 - Role of mitochondrial reactive oxygen species for triggering inflammation during cardiac pressure overload (Project Head Maack, Christoph )
• B05 - Mitochondrial membrane remodelling regulates metabolism and controls innate and adaptive immune responses to myocardial infarction (Project Heads Dudek, Jan Alexander ;  Vaeth, Martin )
• B06 - Heart-specific antibodies as modulators of myocardial infarction (Project Heads Heinze, Katrin G. ;  Ramos, Ph.D., Gustavo C. )
• C01 - Novel PET radiotracer as a specific biomarker of acute inflammation in the heart (Project Heads Decker, Michael ;  Higuchi, Takahiro )
• C02 - Serial prospective multimodal imaging of the lymphatic organs and myocardium to predict cardiac function and remodelling in patients after myocardial infarction (Project Heads Reiter, Theresa Wei-yi Laetitia ;  Werner, Rudolf )
• C03 - Myeloid cell 7T ultra-high field magnetic resonance imaging in pigs as a translational platform for cardiac immunotherapy (Project Heads Bauer, Wolfgang Rudolf ;  Hofmann, Ulrich ;  Schreiber, Laura Maria )
• C05 - Role of anti-heart autoimmunity for disease progression in patients with acute decompensation of heart failure (Project Heads Beyersdorf, Niklas ;  Morbach, Caroline )
• PS1 - Animal model and imaging platform (Project Heads Lorenz, Kristina ;  Maack, Christoph ;  Schreiber, Laura Maria ;  Schuh, Kai )
• PS2 - Single-cell assays to investigate inflammatory dynamics in cardiovascular diseases (Project Heads Cochain, Ph.D., Clement ;  Erhard, Florian ;  Saliba, Antoine-Emmanuel )
• Z - Central Tasks of the Collaborative Research Centre (Project Head Frantz, Stefan )

• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Spokesperson: Professor Dr. Stefan Frantz