SFB 423:  Kidney Pathology: Pathogenesis and Regenerative Mechanisms

• Subject Area: Medicine
• Term: from 1999 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5482962

Different types of acute and chronic kidney disease lead to reduction or loss of renal function. Progressive kidney disease and endstage renal failure is of great medical and socioeconomic relevance. Both, incidence and prevalence of acute and chronic kidney failure have continuously increased in the last decades.
Acute or chronic-irreversible forms of renal failure can be the consequence of various types of injury to the kidney tissue: etiological and pathogenetic causes of renal diseases include immunological, metabolic, ischemic, toxic, infectious, mechanical and hereditary factors.
However, the current knowledge about pathogenetic mechanisms of many of these illnesses is too fragmentary to effective diagnostic and therapeutic measures. Thus, renal replacement therapies (e.g. dialysis and kidney transplantation) are necessary in order to prevent death of uremic patients. While these treatments are life-supporting, their character is only palliative and associated with substantial physical and psychological burdens of the patients, and huge financial costs. In order to develop effective preventive and therapeutic measures to treat renal disease, research efforts are required to obtain new information on the pathogenesis of renal injury and on mechanisms allowing protection or regeneration of kidney structure and function.
The common aim of research within the collaborative research centre 423 is the development of new knowledge about mechanisms of development, damage, regeneration and protection of kidney tissue. Hereby, we expect better understanding of etiology, pathogenesis, progression or healing of certain renal diseases.
The cooperative work within the collaborative research centre 423 will support the synergism of different research activities and thus extend the knowledge in the field of renal pathology. Accordingly, the common research efforts are expected to lead to development of new concepts for rational diagnostic and therapeutic measures for renal diseases.

• DFG Programme: Collaborative Research Centres
• International Connection: USA

Completed projects

• A01 - Molecular mechanisms of glomerular deposition of autoantibodies and their role in the pathogenesis of lupus nephritis (Project Head Winkler, Thomas )
• A02 - Alpha8 Integrin-mediated cell-matrix-interactions in the mesangium of normal and diseased glomeruli and in tubulointerstitial injury (Project Head Hartner, Andrea )
• A3 - Die Regulation der bildung von Fenestrierungen, Poren und Caveolae im Blutgefäßendothel der Niere: MECA-32 und FELS als Mitglieder einer neuen Proteinfamilie von Caveolae-assoziierten Molekülen (Project Head Hallmann, Rupert )
• A5 - Tubuloepitheliale und mesangiale Zellschädigung und Protektion durch Redoxsignale (Project Head Brüne, Bernhard )
• A6 - Protektive Wirkung von Interleukin-15-Fusionsproteinen durch Hemmung der Apoptose nach allogener Nierentransplantation (Project Heads Kunzendorf, Ulrich ;  Tran, Thuong Hien )
• A09 - Die Rolle von Proteinen der Olfactomedin-Familie bei glomerulären Erkrankungen (Project Head Tamm, Ernst R. )
• A12 - Regulation of the epithelial sodium channel (ENaC) (Project Head Korbmacher, Christoph )
• A13 - Genetische Determinanten der Niereninsuffizienz bei Nagel-Patella-Syndrom (Project Head Winterpacht, Andreas )
• A14 - HIF-prolylhydroxylases in the kidney: expression, regulation and effects of inhibition (Project Heads Eckardt, Kai-Uwe ;  Willam, Carsten )
• A15 - The role of the antiapoptotic gene survivin in the kidney (Project Head Wiesener, Michael )
• A16 - Functional characterization of VHL-regulated genes of renal cell carcinoma (Project Head Behrens, Jürgen )
• A18 - The role of p38MAPKá in rapid progressive crescentic glomerulonephritis (Project Heads Schett, Georg ;  Zwerina, Jochen )
• A19 - Molecular elucidation of syndromic disorders with congenital or infantile nephrosis (Project Head Zenker, Martin )
• B1 - Die Bedeutung des Transkriptionsfaktors Egr-1 für die Wachstumsregulation glomerulärer Mesangiumzellen in vivo (Project Head Rupprecht, Harald )
• B2 - Bedeutung von anti-dsDNA-Antikörpern für die Pathogenese der Lupusnephritis (Project Heads Kalden, Joachim R. ;  Winkler, Thomas )
• B03 - Molekulare Mechanismen der Fibroblastendifferenzierung als Ansatzpunkt für antifibrotische Therapie (Project Head Goppelt-Strübe, Margarete )
• B05 - Role of oxidative Stress for the progression of diabetic nephropathy (Project Heads Schmieder, Roland E. ;  Schneider, Markus )
• B06 - The role and therapeutic modulation of Thrombospondin-1 and -2 during development of chronic allograft nephropathy (Project Head Hugo, Christian )
• B08 - Histopathogenese, Mechanismen und Relevanz bei glomerulären Erkrankungen (Project Head Amann, Kerstin )
• B10 - Einfluss von CTGF und Endostation auf die renale Angiogenese und Fibroplasie (Project Heads Bork, Jens Peter ;  Rascher, Wolfgang ;  Schuppan, Detlef )
• B12 - Role of Renal Primary Sensory Neurons in Renal Inflammation and Sclerosis (Project Heads Tiegs, Gisa ;  Veelken, Roland )
• B13 - Renal inflammation after intrauterine growth restriction: mechanisms of perinatal programming and reprogramming (Project Heads Dötsch, Jörg ;  Plank, Christian )
• Z - Zentrale Aufgaben (Project Head Schmieder, Roland E. )
• Z01 - SFB Office / Coordination (Project Head Eckardt, Kai-Uwe )
• Z02 - Quantitative structural analysis (Project Head Amann, Kerstin )
• Z03 - Genetically modified mice (Project Head Winkler, Thomas )

• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Spokesperson: Professor Dr. Kai-Uwe Eckardt