SFB 596:  Molecular Mechanisms of Neurodegeneration

• Subject Area: Medicine ; Biology
• Term: from 2001 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5484845

13 groups are involved in research on neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington, and prion diseases at the university of Munich, the Max-Planck Institute for Biochemisty, and the Max-Planck-Institute for Psychiatry. All projects focus on molecular mechanisms of human neurodegenerative disorders using tissue culture systems or animal models such as transgenic mice, zebrafish, and Caenorhabditis elegans.

• DFG Programme: Collaborative Research Centres

Completed projects

• A01 - Transgenic Alpha-Synuclein Expression in Oligodendrocytes: In-Vivo Models of multiple System Atrophy (Project Head Kahle, Philipp J. )
• A2 - A Null-Mutation für Parkin as a Mouse-Model for Parkinsonism (Project Heads Gasser, Thomas ;  Wurst, Wolfgang )
• A3 - Functional genetic Analysis of Parkinsons Disease-related Genes in Caenorhabditis Elegans (Project Head Baumeister, Ralf )
• A04 - Functional Analysis and bichemical Characterization of the mutant notch3 Receptor; Generation of a transgenic Mouse Model für Cadasil (Project Head Dichgans, Martin )
• A06 - Analysis of synaptic Transmission in transgenic Animal Models of Alzheimers Disease (Project Head Herms, Jochen W. )
• A08 - Intracellular Trafficking and Clearance of PRPSc (Project Head Schätzl, Hermann M. )
• A09 - Post-transcriptional Regulation of ß-Secretase (Bace1) and a-Secretase (Adam10) (Project Heads Haass, Christian ;  Lammich, Sven ;  Willem, Michael )
• A10 - Genetic Analysis of trophic Ret and DJ-1 in the dopaminergic System (Project Head Klein, Rüdiger )
• A11 - Pathophysiology of in vivo Ca2+ signalling in Mouse Models of Alzheimer Disease (Project Head Garaschuk, Olga )
• A12 - Functional Analysis of Genetic Animal Models for Parkinson's Disease (Project Head Wurst, Wolfgang )
• A13 - Kinetics and mechanisms of dendritic spine loss in alzheimer's disease (Project Head Herms, Jochen W. )
• A14 - The role of Parkin in Parkinson's Disease: Physiological Function and pathological Alterations (Project Head Winklhofer, Konstanze )
• A15 - Glial Reactivity and Neurogenesis - Novel Regenerative Approaches in Alzheimer Disease Models (Project Head Götz, Magdalena )
• A16 - Modeling mechanisms of neurodegenerative disease using in vivo imaging in zebrafish (Project Heads Misgeld, Thomas ;  Schmid, Bettina )
• B1 - Functional Analysis of ß-secretase (Bace) and Regulation of subcellular Trafficking (Project Head Haass, Christian )
• B02 - Crystal structure Determination of Proteins Related to Alzheimer`s Disease (Project Heads Bode, Wolfram ;  Than, Manuel E. )
• B3 - Pathogenesis of prion Protein Mutations: Analysis of Aggregation and Cellular Phenotypes (Project Heads Kretzschmar, Hans A. ;  Windl, Otto )
• B04 - Functional characterization of physiological and neurotoxic Conformers of the prion protein (Project Head Tatzelt, Jörg )
• B06 - Mechanisms of proteotoxicity in neurodegenerative Diseases (Project Head Hartl, Franz-Ulrich )
• B7 - Analysis of the cellular Function of FMRP, the Disease Gene Product of Fragile X Syndrome (Project Head Fischer, Utz )
• B8 - Funkctional Analysis of neuronal estrogen receptor Target Genes (Project Head Behl, Christian )
• B09 - Functional Characterization of y-Secretase (Project Heads Haass, Christian ;  Steiner, Harald )
• B10 - Lipid-Protein Interaction in Neurodegeneration: Modulation of Protein Aggregation and Fibrillization at the Membrane-Water Interface (Project Head Beyer, Klaus )
• B12 - Regulation of Ectodomain Shedding of the amyloid Precursor Protein (Project Head Lichtenthaler, Stefan )
• B13 - Co-Aggregation of Amyloidogenic Peptides (Project Heads Giese, Armin ;  Kretzschmar, Hans A. )
• B14 - Analysis of prion strain dissemination and the role of glycosamino-glycans in prion cell culture models (Project Head Vorberg, Ina Maja )
• B15 - Molecular requirements for prion propagation (Project Head Kretzschmar, Hans A. )
• B16 - TDP-43 as disease protein in FTLD-U and ALS: Transgenic models for TDP-43 Proteinopathies and Physiologic function of TDP-43 in the brain (Project Head Neumann, Manuela )
• N01 - Unwrapping Myelination in the Zebrafish (Project Head Brösamle, Ph.D., Christian )
• N01 - Unwrapping Myelination in the Zebrafish (Project Head Brösamle, Ph.D., Christian )
• V01 - Administration, Travel, Meetings and Seminars of the Collaborative Research Centre (Project Head Haass, Christian )
• Z01 - Protein Analysis unit / core facility (Project Head Imhof, Axel )
• Z02 - Core facility monoclonal antibodies for SFB 596 (Project Head Kremmer, Elisabeth )

• Applicant Institution: Ludwig-Maximilians-Universität München
• Participating University: Technische Universität München (TUM)
• Participating Institution: Helmholtz Zentrum München; Deutsches Forschungszentrum für Gesundheit und Umwelt; Max-Planck-Institut für Biochemie (MPIB); Max-Planck-Institut für Neurobiologie (MPIN) (aufgelöst)
• Spokesperson: Professor Dr. Christian Haass