Project Details
Projekt
FOR 630: Biological Function of Organometallic Compounds
Subject Area
Chemistry
Medicine
Medicine
Term
from 2006 to 2015
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 14065420
Bioorganometallic Chemistry is a young and interdisciplinary field of study. This Research Unit will establish organometallic chemistry as part of medicinal chemistry. Selected classes of organometallic compounds will be studied in their interaction with cellular components like receptors, proteins, peptides and DNA. The compounds will be optimised by variation of structural properties with respect to cellular uptake, intracellular localisation, and finally, their cytotoxic properties. We are aiming to identify metal-specific mechanisms of cytotoxicity.
The findings will guide the design of novel metal-based lead structures and contribute to the understanding of signalling pathways and protein expression patterns. The seven participating groups combine a broad expertise from organic and metal-organic synthesis to analytical chemistry, biochemistry and cell biology. By combining the broad and diverse expertise of these groups, the core of a competent network is formed that will contribute to the development of medicinal bioorganometallic chemistry in Germany and beyond.
The findings will guide the design of novel metal-based lead structures and contribute to the understanding of signalling pathways and protein expression patterns. The seven participating groups combine a broad expertise from organic and metal-organic synthesis to analytical chemistry, biochemistry and cell biology. By combining the broad and diverse expertise of these groups, the core of a competent network is formed that will contribute to the development of medicinal bioorganometallic chemistry in Germany and beyond.
DFG Programme
Research Units
International Connection
Austria
Projects
- Design und Struktur-Wirkungsbeziehungen von cytotoxischen Rhodium(III)- und Iridium(III)-Komplexen (Applicant Sheldrick, William S. )
- Markierung von Peptidhormonen mit Metallkomplexen für Tumordiagnostik und -therapie (Applicants Beck-Sickinger, Annette G. ; Neundorf, Ines )
- Oktaedrische Iridiumverbindungen als Proteinkinase-Inhibitoren (Applicant Meggers, Eric Leif )
- Optimierung auf Metallen basierender Wirkkomponenten für Tumortherapeutika (Applicants Gust, Ronald ; Ott, Ingo )
- Organometall-Peptidkonjugate: Modulation der Cytotoxizität durch gezielte Veränderung von Aufnahme und zellulärer Lokalisierung (Applicant Metzler-Nolte, Nils )
- Rationelles Design und Targetermittlung von potentiell antitumorwirksamen Organoruthenium- und Organoiridiumkomplexen (Applicant Sheldrick, William S. )
- Wirkstoffprüfung und Targetidentifizierung von neuartigen organometallischen Verbindungen und präklinische Evaluation für die Therapie maligner Erkrankungen im Kindesalter (Applicants Prokop, Aram ; Wölfl, Stefan )
- Zentrale Mittel für den Sprecher der FOR 630 "Biologische Funktion von Organometallverbindungen" (Applicant Metzler-Nolte, Nils )
- Zytotoxizität von Metallcarbonyl-Komplexen mit und ohne Photoaktivierung (Applicant Schatzschneider, Ulrich )
- Übergangsmetall-komplexierte Naturstoffderivate: Synthese und biologische Evaluierung metallhaltiger Nucleoside, Aminosäurederivate und Analoga anderer relevanter Naturstoffe als potentielle Tumortherapeutika (Applicant Schmalz, Hans-Günther )
Spokesperson
Professor Dr. Nils Metzler-Nolte
