TRR 205:  The Adrenal: Central Relay in Health and Disease

• Subject Area: Medicine ; Agriculture, Forestry and Veterinary Medicine ; Biology ; Chemistry
• Term: since 2017
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

No abstract available

• DFG Programme: CRC/Transregios
• International Connection: France

Current projects

• A01 - Ferroptotic cell death in adrenal inflammation and septic shock (Project Heads Bornstein, Stefan R. ;  Kanczkowski, Waldemar ;  Linkermann, Andreas )
• A02 - The systemic influence of adrenal hypoxia pathway proteins: from physiological functions to pathological alterations (Project Heads Chavakis, Triantafyllos ;  El-Armouche, Ali ;  Wielockx, Ph.D., Ben )
• A04 - Novel diagnostic, therapeutic and monitoring options in congenital adrenal hyperplasia (Project Heads Hübner, Ph.D., Angela ;  Köhler, Katrin ;  Reisch, Nicole )
• A05 - Cell-based, immune-protected therapy for patients with adrenal insufficiency (Project Heads Bornstein, Stefan R. ;  Ludwig, Barbara )
• A06 - Translating strategies for adrenal regeneration and healthy function (Project Heads Andoniadou, Ph.D., Cynthia L. ;  Bornstein, Stefan R. ;  Schedl, Andreas ;  Steenblock, Charlotte )
• A07 - Metabolic regulation of adrenocortical function (Project Heads Alexaki, Vasileia Ismini ;  Eaton, Suzanne ;  Henneicke, Ph.D., Holger )
• A08 - Crossroads of stress response: epigenetic and epitranscriptomic changes as cause and effect of cortisol secretion and their therapeutic potential (Project Heads Chen, Alon ;  Riester, Anna ;  Sbiera, Silviu )
• A09 - Development of sex-specific therapeutic approaches towards glucocorticoids-driven metabolic dysfunction (Project Heads Herzig, Stephan ;  Uhlenhaut, Nina Henriette )
• B11 - Towards personalized treatment strategies for aggressive PPGLs: novel biomarkers and therapeutic approaches (Project Heads Mohr, Hermine ;  Nölting, Svenja ;  Pellegata, Natalia S. )
• B12 - Neural-crest derived catecholamine producing tumours: implementation of molecular and metabolic fingerprints to predict disease progression and therapeutic response (Project Heads Bechmann, Nicole ;  Eisenhofer, Ph.D., Graeme ;  Klink, Barbara ;  Lenders, Ph.D., Jacques W.M. ;  Pamporaki, Ph.D., Christina )
• B13 - Improvement and dissemination of molecular imaging and therapy of adrenocortical tumours (Project Heads Fuß, Carmina Teresa ;  Hahner, Stefanie ;  Reincke, Martin ;  Schirbel, Andreas )
• B14 - Reversibility of organ damage in primary aldosteronism: role of salt-dependent mechanisms (Project Heads Beuschlein, Felix ;  Gudermann, Thomas ;  Reincke, Martin ;  Schneider, Holger )
• B15 - Pathophysiology and advanced approaches for subtyping and diagnostic stratification in primary aldosteronism (Project Heads Eisenhofer, Ph.D., Graeme ;  Lenders, Ph.D., Jacques W.M. ;  Williams, Ph.D., Tracy Ann )
• B16 - Steroid hormones and cancer immunity – learning from adrenocortical carcinoma (Project Heads Fassnacht, Martin ;  Hudecek, Michael ;  Kroiß, Ph.D., Matthias ;  Landwehr, Laura-Sophie )
• B17 - Mechanisms and prediction strategies for refractory corticotroph tumours (Project Heads Reincke, Martin ;  Theodoropoulou, Marily )
• B19 - Development and pharmacological characterisation of a pig model for primary aldosteronism (Project Heads Kemter, Elisabeth Gabriele ;  Williams, Ph.D., Tracy Ann ;  Wolf, Eckhard )
• B20 - Exploiting ferroptosis-based strategies in cancers of the adrenal (Project Heads Alborzinia, Ph.D., Hamed ;  Friedmann Angeli, José Pedro ;  Fuß, Carmina Teresa ;  Kroiß, Ph.D., Matthias ;  Weigand, Isabel )
• INF - Information infrastructure for adrenal research (Project Heads Beuschlein, Felix ;  Eisenhofer, Ph.D., Graeme ;  Fassnacht, Martin ;  Müller-Pfefferkorn, Ralph ;  Reisch, Nicole )
• S01 - Analytical platform (Project Heads Alves, Tiago ;  Bidlingmaier, Martin ;  Kurlbaum, Max ;  Peitzsch, Mirko ;  Walch, Axel Karl )
• S02 - Clinical studies and biobanks (Project Heads Chifu, Irina ;  Eisenhofer, Ph.D., Graeme ;  Fassnacht, Martin ;  Pamporaki, Ph.D., Christina ;  Reincke, Martin )
• Z01 - Central tasks of the Collaborative Research Centre/ Transregio 205 (Project Head Bornstein, Stefan R. )

Completed projects

• A03 - Understanding the mechanisms leading to autoimmune adrenalitis by generating the first experimental animal model (Project Head Chavakis, Triantafyllos )
• B10 - Targeting radio- and chemo-resistance in metastatic phaeochromocytoma/ paraganglioma (Project Heads Pietzsch, Jens ;  Richter, Ph.D., Susan ;  Ziegler, Ph.D., Christian G. )

• Applicant Institution: Technische Universität Dresden
• Co-Applicant Institution: Julius-Maximilians-Universität Würzburg; Ludwig-Maximilians-Universität München
• Participating University: Technische Universität München (TUM)
• Participating Institution: Helmholtz Zentrum München; Deutsches Forschungszentrum für Gesundheit und Umwelt
• Spokesperson: Professor Dr. Stefan R. Bornstein