SFB 1350:  Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk

• Subject Area: Medicine ; Biology
• Term: from 2019 to 2022
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280

Chronic kidney disease (CKD) is of great medical and socio-economic significance and is associated with high mortality. CKD can result from either systemic diseases, such as diabetes mellitus and arterial hypertension, or diseases primarily affecting the kidney, such as primary glomerular diseases, tubular defects, and cystic kidney disease. Regardless of the underlying cause of CKD, the tubular system and interstitial cells are critically involved in either the development or progression of chronic kidney disease and thus have a central position in the pathogenesis of this common disease. Normally, the different cell types of the tubular system and interstitium work together in a coordinated and finely tuned way, thereby allowing the kidney to adapt to various physiological needs. Importantly, many renal disease processes also affect more than one cell type and elicit complex responses in tubules and interstitium. These processes can turn maladaptive and aggravate disease progression. The underlying mechanisms are yet poorly understood and examining the exact nature of the complex crosstalk between tubular cells and interstitial cells is technically demanding and requires an integrative, multidisciplinary approach. The overarching aim of CRC 1350 is to gain insights into the (patho-) physiology of the tubular system and the renal interstitium using a comprehensive and interdisciplinary strategy. In particular, we aim to improve understanding of the diverse functions of the various cell types and their crosstalk during disease progression and regeneration processes in the kidney. The expected results of the collaboration between basic researchers and clinical scientists can help identify novel targets and develop future therapeutic strategies for chronic kidney disease.

• DFG Programme: Collaborative Research Centres

Completed projects

• A01 - Mechanisms of early ciliogenesis (Project Head Witzgall, Ralph )
• A02 - Slowing polycystic kidney disease by inhibition of HIF-1α-dependent- and calcium-mediated secretory signaling pathways (Project Head Buchholz, Björn )
• A03 - CFTR and TMEM16A/F in polycystic kidney disease and metabolic alkalosis (Project Heads Kunzelmann, Karl ;  Schreiber, Rainer )
• A04 - Tubular and interstitial proteases as regulators of the epithelial sodium channel (ENaC) (Project Heads Härteis, Silke ;  Korbmacher, Christoph )
• A05 - Molecular mechanisms of transport and inhibition in SGLTs (Project Head Ziegler, Christine Maria )
• A06 - Cardio- and nephroprotective mechanisms of SGLT2 inhibition (Project Heads Maier, Lars ;  Schweda, Frank ;  Wagner, Stefan )
• A07 - Low molecular weight proteinuria caused by a mutation of the Vesicle Associated Protein (VAP) (Project Head Warth, Richard )
• B01 - (Patho-) physiology of resident PDGFRβ+ interstitial cells in the kidney (Project Heads Kurtz, Armin ;  Wagner, Charlotte )
• B02 - Assessment of the structure and function of the renal interstitium by intravital multiphoton microscopy (Project Heads Castrop, Hayo ;  Schießl, Ina Maria )
• B03 - Fibronectin and its role in polycystic kidney diseases (Project Heads Buchholz, Björn ;  Tamm, Ernst R. )
• B04 - Relevance of inflammation and fibrosis for renal regeneration (Project Head Mack, Matthias )
• B05 - Role of prolyl-hydroxylase domain enzyme inhibitors in chronic renal inflammation (Project Heads Jantsch, Jonathan ;  Willam, Carsten )
• B06 - Relevance of immigrating B-lymphocytes and their functional properties for the development of allograft nephropathy (Project Heads Banas, Bernhard ;  Bergler, Tobias ;  Geissler, Ph.D., Edward K. )
• C02 - Complement-mediated crosstalk between tubular and interstitial cells in renal transplantation - focus on the lectin-activated pathway (Project Heads Amann, Kerstin ;  Büttner-Herold, Maike ;  Daniel, Christoph )
• C03 - Endocrine communication of renal tubules (Project Head Schweda, Frank )
• C04 - Pathogenesis of Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) (Project Head Wiesener, Michael )
• C05 - Epigenetic identity and plasticity of renal tubular and interstitial cells (Project Head Schödel, Ph.D., Johannes )
• C06 - Prioritizing genes for kidney function decline in the population and high risk groups (Project Heads Böger, Carsten A. ;  Heid, Iris M. )
• Z01 - Intravital multiphoton microscopy (Project Head Castrop, Hayo )
• Z02 - Proteome and metabolome analyses (Project Heads Dettmer-Wilde, Katja ;  Gronwald, Wolfram ;  Oefner, Peter )
• Z03 - Central Tasks of the Collaborative Research Center (Project Head Warth, Richard )
• Z04 - Electron microscopy (Project Heads Rachel, Reinhard ;  Witzgall, Ralph )

• Applicant Institution: Universität Regensburg
• Participating University: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Spokesperson: Professor Dr. Richard Warth