SPP 1089:  Neue Vakzinierungsstrategien

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2000 bis 2006
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5470124

Keine Zusammenfassung vorhanden

• DFG-Verfahren: Schwerpunktprogramme

Projekte

• Dendritic cell-based vaccination against infection: analysis of the parameters determining the protective of dendritic cells in the modell of leishmaniasis (Antragstellerin Moll, Heidrun )
• Development of a Yersinia oral live carrier vaccine: Influence of the typeIII-secreted/translocated effector proteins (Yops) on the immune response (Antragsteller Heesemann, Jürgen )
• Development of optimized adjuvant vectors for DNA vaccination (Antragsteller Haas, Jürgen )
• Development of protein-based subunit vaccines against Streptococcus pneumoniae (Antragsteller Chhatwal, Gursharan Singh )
• Development of Yersinia carrier systems for vaccination and investigation of cell-mediated Immune responses (Antragsteller Autenrieth, Ingo Birger )
• Entwicklung einer oralen Amöbiasisvakzine unter Verwendung rekombinanter, attenuierter Yersinia enterocolitica (Antragsteller Tannich, Egbert )
• Generation and characterization of recombinant coxsackievirus replicons for prevention of virus-induced heart disease (Antragsteller Henke, Andreas )
• Identification of low-molecular mass ligands for targeting of subunit vaccines to Peyer`s patch M cells (Antragsteller Frey, Andreas )
• Immunisation protokolls utilising cpG-DNA coupled proteins for the activation of Dendritic Cells (DCs) with special emphasis on the cross-presentation/priming ability of plasmacytoid DCs (Antragsteller Wagner, Hermann )
• Impact of compartimentalized antigen expression by Mycobacterium bovis Bacille Calmette-Guérin (BCG) on the induction of T-cell mediated immunity (Antragsteller Hess, Jürgen )
• Induction of Mucosal Immune Responses by the AIDA Autotransporter-mediated Presentation of Heterologous Antigens in (Commensal) Live Vectors (Antragsteller Schmidt, Marcus Alexander )
• Kombinierte CpG-Oligodeoxynukleotid/Lipopeptid Liposomen als neuer immunmodulatorischer Impfstoff gegen Hepatitis C Virus Infektion (Antragsteller Spengler, Ulrich )
• Kombinierte CpG-Oligodeoxynukleotid/Lipopeptid Liposomen als neuer immunmodulatorischer Impfstoff gegen Hepatitis C Virus Infektion (Antragsteller Will, Hans )
• Live vaccines based on virulence-attenuated Listera monocytogenes carrying novel plasmid vectors - a comparison of efficiency (Antragsteller Goebel, Werner )
• Native display of Borrelia antigens on the surface of hepatitis B virus capsids: Improved prophylactic and potential therapeutic vaccines against Lyme disease (Antragsteller Nassal, Michael )
• Native display of Borrelia antigens on the surface of hepatitis B virus capsids: Improved prophylactic and potential therapeutic vaccines against Lyme disease (Antragsteller Simon, Markus Michael )
• Oligodesoxynucleotides as adjuvants: Use in prophylactic and therapeutic vaccines (Antragsteller Zimmermann, Stefan )
• Oligodesoxynucleotides as adjuvants: Use in prophylactic and therapeutic vaccines (Antragsteller Heeg, Klaus Michael )
• Optimisation of host immune responses against vaccine antigens (Antragsteller Guzman, Ph.D., Carlos Alberto )
• Optimisation of recombinant Helicobacter pylori Ghosts for vaccination in H. pylori mouse and Mongolian Gerbil models (Antragsteller Haas, Rainer )
• Optimization of Salmonella-mediated oral vaccination (Antragsteller Weiß, Siegfried )
• Protective mechanism of Salmonella-based vaccination against Helicobacter pylori in mice (Antragsteller Meyer, Thomas F. )
• Rational vaccination strategy against tuberculosis based on heat shock protein/polypeptide complexes (Antragsteller Kaufmann, Stefan H.E. )
• Recombinant live herpesvirus vaccines (Antragsteller Koszinowski, Ulrich H. )
• Recombinant Respiratory Syncytial Virus Vectors for Immunization of Respiratory Epithelia (Antragsteller Conzelmann, Karl-Klaus )
• Role of dendritic cells as adjuvants and carrier of microbial antigens in mucosal immunization (Antragsteller Beuscher, Horst Ulrich )
• Salmonella as a live carrier for recombinant vaccines: Rational design of improved carrier strains (Antragsteller Hensel, Michael )
• Salmonella type III-mediated antigen targeting to induce cellular immunity: characterzition of effector and memory T cell populations after oral vaccination (Antragsteller Rüssmann, Holger )

• Sprecher: Professor Dr. Stefan H.E. Kaufmann