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Ruprecht-Karls-Universität Heidelberg
Zentrum für Molekulare Biologie (ZMBH)

Address Im Neuenheimer Feld 282
69120 Heidelberg
Deutschland

GERiT This institution in GERiT

69120 Heidelberg

Projects

Research Grants
- Current projects
  - Allosteric mechanisms of AAA+ machines: the case of the central bacterial protease ClpC/ClpP
    (Applicant Mogk, Axel )
  - Coordination of mRNA translation with the action of ribosome-associated chaperones in yeast
    (Applicant Kramer, Günter )
  - DBT-DFG Indo-German Research Proposal: The recruitment of the γ-TuRC to the Sas-6 cartwheel for centriole microtubule assembly
    (Applicant Schiebel, Elmar )
  - Dynamic regulation of the modular assembly of the mitochondrial respiratory chain
    (Applicant Vögtle, Friederike-Nora )
  - Functional and structural analysis of gamma-tubulin complexes
    (Applicants Pfeffer, Stefan ; Schiebel, Elmar )
  - Functional specification of HSP70 by J-domain protein co-chaperones
    (Applicant Bukau, Bernd )
  - Mechanisms of Hsp100 chaperones
    (Applicant Mogk, Axel )
  - Mechanisms of small heat shock protein sequestrases
    (Applicants Bukau, Bernd ; Mogk, Axel )
  - Molecular mechanism of the Hsp70 Chaperone network
    (Applicant Mayer, Matthias Peter )
  - Molecular mechanism of the regulation of the mammalian heat shock transcription factor Hsf1
    (Applicant Mayer, Matthias Peter )
  - Spatial organisation of centrosomes by centrosome cohesion and centrosome nuclear envelope interactions.
    (Applicant Schiebel, Elmar )
  - The cellular origins and evolution of the maternal-fetal interface in mammals
    (Applicants Anders, Simon ; Kaessmann, Ph.D., Henrik ; Stegle, Ph.D., Oliver )
  - The role of actin in the γ-TuRC
    (Applicants Pfeffer, Stefan ; Schiebel, Elmar )
  - The role of the centriolar CEP350 network in centrobin removal from centrioles and distal appendage/CEP19 recruitment
    (Applicants Pereira, Gislene ; Schiebel, Elmar )
  - The role of the hCDC14B-HIPK2-MeCP2 axis in mitotic cell fate determination.
    (Applicant Schiebel, Elmar )
- Completed projects
Priority Programmes
- Current projects
- Completed projects
Heisenberg Fellowships
- Completed projects
  - Molekularbiologie
    (Applicant Mogk, Axel )
Research Units
- Current projects
  - FOR 2509: The concert of dolichol-based glycosylation: from molecules to disease models
    (Spokesperson Strahl, Sabine )
  - Monitoring the glycosylation network by quantitative mass spectrometry to study its functional and structural organization
    (Applicant Luzarowski, Marcin )
- Completed projects
  - Coordination of translation and assembly of protein complexes
    (Applicant Kramer, Günter )
  - FOR 1805: Ribosome Dynamics in Regulation of Speed and Accuracy of Translation
    (Spokesperson Ignatova, Zoya )
  - Functional analysis of enzymes involved in the co-translational modification of nascent chains
    (Applicant Bukau, Bernd )
Independent Junior Research Groups
- Completed projects
  - Novel roles of the mitochondrial presequence processing machinery in health and disease
    (Applicant Vögtle, Friederike-Nora )
WBP Position
- Current projects
  - Role of the DEAD-box helicases CshA and CshB in bacterial translational quality control
    (Applicant Rodriguez Carvajal, Ph.D., Alan )
Collaborative Research Centres
- Current projects
  - Central tasks of the SFB
    (Project Head Bukau, Bernd )
  - Diverse functions of the mitochondrial presequence processing machinery
    (Project Head Vögtle, Friederike-Nora )
  - Fusion of the inner and outer nuclear membranes during nuclear pore complex assembly
    (Project Head Schiebel, Elmar )
  - Membrane remodelling during the mitochondrial unfolded protein response
    (Project Head Vögtle, Friederike-Nora )
- Completed projects
  - Applying quantitative profiling and imaging methods to explore the proteolytic plasticity of protein N-termini and protein misfolding processest
    (Project Heads Doroudgar, Ph.D., Shirin ; Knop, Michael )
  - Bioinformatic analysis and comparative data mining
    (Project Heads Kaessmann, Ph.D., Henrik ; Lohmann, Jan )
  - Biology and mechanisms of the translational stress signalling protein, Rqc2
    (Project Head Joazeiro, Claudio )
  - Das Merozoitenoberflächenprotein 1 (MSP-1), ein Kandidat für einen Impfstoff gegen P.falciparum-Infektionen: Untersuchungen zur zellulären Immunantwort des Menschen
    (Project Head Bujard, Hermann )
  - Die Rolle von molekularen Chaperonen bei der de novo Faltung von Proteinen in E. Coli
    (Project Heads Bukau, Bernd ; Deuerling, Elke )
  - Die Rolle von molekularen Chaperonen bei der de novo Faltung von Proteinen in E.coli
    (Project Heads Bukau, Bernd ; Deuerling, Elke )
  - Flow Cytometry/Fluorescence Activated Cell Sorting (FACS)
    (Project Heads Knop, Michael ; Sourjik, Victor )
  - Functional analysis of the RanGAP1 SUMO-1/RanBP2 complex in interphase und mitosis
    (Project Head Melchior, Frauke )
  - Funktion eines RNA-bindenden Proteins beim Transport und der Translation von mRNA
    (Project Head Seedorf, Matthias )
  - Glykosomale Membranproteine
    (Project Heads Clayton, Christine Elizabeth ; Lorenz, Patrick )
  - Interplay of Hsp70/J-domain proteins and sequestrases in organization of protein quality control and stress response in yeast
    (Project Heads Bukau, Bernd ; Mogk, Axel )
  - Inter-tissue proteostasis networks to combat α-synuclein mediated endo-lysosomal damage in C. elegans
    (Project Head Nussbaum-Krammer, Carmen )
  - Mechanism and dynamics of Hsp70 and Hsp90-assisted folding of Transcription factors and kinases
    (Project Head Mayer, Matthias Peter )
  - Mechanism of action of ribosome-associated chaperones in co-translational folding and transport of proteins
    (Project Heads Bukau, Bernd ; Kramer, Günter )
  - Molecular mechanism of the heat shock transcription factor Hsf1
    (Project Head Mayer, Matthias Peter )
  - Nuclear envelope insertion of the yeast centrosome
    (Project Head Schiebel, Elmar )
  - Protein analysis by mass spectrometry
    (Project Heads Lechner, Johannes ; Ruppert, Thomas )
  - Quantitative protein analysis
    (Project Heads Mayer, Matthias Peter ; Ruppert, Thomas )
  - Regulation der Translokation von Protein durch die Membran des endoplasmatischen Retikulums
    (Project Head Dobberstein, Bernhard )
  - Regulatory and phenotypic evolution of the male mammalian germline and underlying stem cells
    (Project Head Kaessmann, Ph.D., Henrik )
  - Release of hCdc14B phosphatase from the nucleolus in response to DNA damage
    (Project Head Schiebel, Elmar )
  - RNA binding proteins in gene regulation and survival
    (Project Head Clayton, Christine Elizabeth )
  - SFB 523: Protein and Membrane Transport between Cellular Compartments
    (Spokesperson Melchior, Frauke )
  - SFB 1036: Cellular Surveillance and Damage Response
    (Spokesperson Bukau, Bernd )
  - Signal peptides and the insertion of TA proteins into te membrane of the endoplasmic reticulum
    (Project Head Dobberstein, Bernhard )
  - SUMOylation in Oxidative Stress Response
    (Project Head Melchior, Frauke )
  - Sumoylation of nuclear transport receptors
    (Project Head Melchior, Frauke )
  - Trypanosoma brucei: neue und alte Ziele für die Chemotherapie
    (Project Head Clayton, Christine Elizabeth )
  - Zelluläre Funktionen und Mechanismus des Hsp70-Chaperonsystems
    (Project Heads Bukau, Bernd ; Mayer, Matthias Peter )
  - Zelluläre Funktionen und Mechanismus des HSP70-Chaperonsystems
    (Project Heads Bukau, Bernd ; Mayer, Matthias Peter )
  - Zentrale Protein- und Nukleinsäurechemie
    (Project Head Frank, Rainer Wolfram )
  - Zentrales Verwaltungsprojekt
    (Project Head Melchior, Frauke )
Emmy Noether International Fellowships
- Completed projects
  - Analyse von Transkriptionsfaktor-Genen beim Menschen durch Vergleiche mit anderen Genomen
    (Applicant Kaessmann, Ph.D., Henrik )
Research Fellowships
- Completed projects
Major Research Instrumentation
- Completed projects
CRC/Transregios
- Completed projects
  - Analysis of a SUMO switch in EGF receptor signaling
    (Project Heads Blüthgen, Nils ; Melchior, Frauke )
  - Centromeric Chromatin
    (Project Head Schiebel, Elmar )
  - Targeting the chaperone Hsp90 as a novel therapeuticc strategy in HCC
    (Project Heads Kern, Michael ; Mayer, Matthias Peter ; Singer, Stephan )
Research Training Groups
- Current projects
  - GRK 2606: Understanding protease functions in cellular pathways through discovery and analysis of protease substrates (ProtPath)
    (Spokesperson Reinheckel, Thomas )
- Completed projects
  - GRK 230: Molecular Cell Biology
    (Spokesperson Dobberstein, Bernhard )
  - GRK 300: Pathogenic Microorganisms: Molecular Mechanisms and Genomic Approaches
    (Spokesperson Clayton, Christine Elizabeth )
  - GRK 388: Biotechnology: Biochemical and Molecular Foundation
    (Spokesperson Wink, Michael )
  - GRK 521: Protein-Protein Interactions during Intracellular Transport of Macromolecules
    (Spokesperson Doenecke, Detlef )
  - GRK 1188: Quantitative Analysis of Dynamic Processes in Membrane Transport and Translocation
    (Spokespersons Fackler, Ph.D., Oliver T. ; Nickel, Walter )
Clusters of Excellence
- Completed projects
  - EXC 81: Cellular Networks: From Analysis of Molecular Mechanisms to a Quantitative Understanding of Complex Functions (CellNetworks)
    (Spokesperson Kräusslich, Hans-Georg )
Graduate Schools
- Completed projects
  - GSC 249: The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology
    (Spokesperson Wittbrodt, Joachim )
NFDI technical and methodological consortia
- Current projects
  - NFDI4Biodiversity – Biodiversity, Ecology & Environmental Data
    (Spokesperson Glöckner, Frank Oliver )

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