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Institution
Universität zu Köln
Department für Chemie
Institut für Biochemie
Address
Otto-Fischer-Straße 12-14
50674 Köln
Deutschland
GERiT
This institution in GERiT
50674 Köln
Projects
Priority Programmes
Current projects
Coordination of proteostasis and mitochondrial intermembrane space protein import
(Applicants
Hoppe, Thorsten
;
Riemer, Jan
)
Completed projects
Mitochondrial and cytosolic maturation of human FeS-dependent molybdenum cofactor synthesis MOCS1A proteins and links between both cofactor pathways
(Applicant
Schwarz, Günter
)
Redox regulation of human adenylate kinase 2 (AK2), an essential key controller of energy metabolism
(Applicant
Riemer, Jan
)
Sensor modules of the osmoregulatory glycine betaine uptake carrier from Corynebacterium glutamicum: structure and interaction with the transport domain Transport-Domäne
(Applicant
Krämer, Reinhard
)
SPP 1070: Struktur funktioneller Module von energiewandelnden Systemen in Prokaryoten
(Spokesperson
Krämer, Reinhard
)
Structure of functional modules from energy-transducing complexes in prokaryotes
(Applicant
Krämer, Reinhard
)
Research Grants
Current projects
Controlling collagen deposition by fibroblasts in cutaneous fibrosis by targeting TANGO1 function
(Applicants
Krieg, Thomas
;
Sengle, Gerhard
)
Exploration and Exploitation of Secondary Sites of Protein Kinase CK2
(Applicants
Jose, Joachim
;
Niefind, Karsten
)
Structural conformations of kainate receptors in physiology and pathophysiology
(Applicant
Brown, Ph.D., Patricia
)
Completed projects
Activation and Inactivation Mechanisms of Membrane-bound Guanylyl Cyclases
(Applicant
Behrmann, Elmar
)
Crystallizations and X-ray structure determination of sulfite oxidas and nitrate reductase (molybdenum domai) from Arabidopsis thaliana
(Applicant
Schwarz, Günter
)
Edelgase und Stickstoff in Mars-Meteoriten als Hinweise zur Entwicklung der Mars-Atmosphäre
(Applicant
Jochum, Klaus Peter
)
Functionalization of LbL-Microcarriers as Drug Delivery System for Elastase Inhibitors and HOCl Scavengers for the Termination of Chronic Inflammation
(Applicant
Reibetanz, Uta
)
Geschlechtsspezifische Regulation der Mitochondrienfunktion im ZNS durch Östrogen im Morbus Parkinson-Tiermodell
(Applicant
Arnold, Susanne
)
Mechanism of selective metal incorporation and cofactor maturation during tungsten cofactor biosynthesis
(Applicant
Schwarz, Günter
)
Mia40 and ALR substrates: initial steps in biogenesis and regulation
(Applicant
Riemer, Jan
)
Molecular mechanisms of nitrate reduction, NO synthesis and post-translational regulation of plant nitrate reductases
(Applicant
Schrader, Katrin
)
Molybdän-Cofaktor-Defizienzen beim Menschen
(Applicant
Schwarz, Günter
)
NOVEL TARGETS OF THE SULFHYDRYL : CYTOCHROME C OXIDOREDUCTASE ALR
(Applicant
Riemer, Jan
)
Nuclear Activities of DNA-Associated Immune Receptors
(Applicants
Niefind, Karsten
;
Parker, Jane E.
)
Regulation der Glucosylglycerol-Konzentration in Synechocystis sp. PCC 6803
(Applicant
Marin, Kay
)
Sensing, signal transduction, and conformational coupling of the transporter BetP and the two component system MtrAB from Corynebacterium glutamicum
(Applicant
Krämer, Reinhard
)
Structural and biochemical characterisation of plant EDS1 disease resistance regulatory complexes
(Applicants
Niefind, Karsten
;
Parker, Jane E.
)
Structural and genetic variability of the proteostasis network in Saccharomyces cerevisiae.
(Applicant
Weith, Matthias
)
Structure-function-correlations of protein kinase CK2
(Applicant
Niefind, Karsten
)
Structure-function relationships in the collagen-specific chaperone Hsp47: Crystal structure, in-vivo and invitro studies and development of antifibrotic agents.
(Applicant
Baumann, Ulrich
)
Structure-function relationships of protein kinase CK2
(Applicants
Niefind, Karsten
;
Pietsch, Markus
)
Struktur und Funktion von Hydroxyprolin-Glykanen in Chlamydomonas reinhardtii
(Applicant
Waffenschmidt, Sabine
)
Studies on the absolute configuration of hydroxy- and epoxyiridals
(Applicant
Marner, Franz-Josef
)
Systematic and comprehensive interdisciplinary analysis of all Martian meteorites - TOF-SIMS investigation
(Applicant
Stephan, Thomas
)
Systematische und umfassende interdisziplinäre Analyse aller Marsmeteorite
(Applicant
Herpers, Ulrich
)
Systematische und umfassende interdisziplinäre Analyse aller Marsmeteorite
(Applicant
Michel, Rolf
)
Systematische Untersuchungen der Stoßwellenmetamorphose aller Marsmeteorite (Systematic investigation of shock metamorphism of all Martian meteorites)
(Applicant
Greshake, Ansgar
)
Tailoring of a membrane-active peptide with dual biological activities
(Applicant
Neundorf, Ines
)
The structural and functional basis of neuroreceptor clustering by gephyrin
(Applicants
Schindelin, Hermann
;
Schwarz, Günter
)
Independent Junior Research Groups
Completed projects
The regulation of oxidative energy metabolism in astrocytes in coordination with neuronal activity
(Applicant
Arnold, Susanne
)
Collaborative Research Centres
Current projects
Integrated Research Training Group "mito-RTG"
(Project Heads
Dohmen, Jürgen
;
Riemer, Jan
)
Metabolic signaling as a safeguard of translational fidelity
(Project Heads
Ignatova, Zoya
;
Weith, Matthias
)
Mitochondrial Hydrogen Peroxide Signalling
(Project Head
Riemer, Jan
)
Protein targeting and safeguarding upon oxidative unfolding stress
(Project Head
Ulrich, Kathrin
)
Stress-dependent regulation of organellar proteome plasticity by dynamic selection of different translation initiation sites
(Project Head
Riemer, Jan
)
Sulfite-dependent regulation of mitochondrial function by sulfite oxidase
(Project Head
Schwarz, Günter
)
Completed projects
Ferroptosis and regulated cell death in sulphite oxidase deficiency
(Project Head
Schwarz, Günter
)
Functional and structural basis of the 14-3-3 mediated inhibition of plant nitrate reductase activity
(Project Head
Schwarz, Günter
)
Post-translation control of gephyrin clustering at inhibitory synapses: phosphorylation and palmitoylation
(Project Head
Schwarz, Günter
)
Proteolysis as a regulatory principle in GlnK stability and the network of nitrogen control in Corynebacterium glutamicum
(Project Heads
Burkovski, Ph.D., Andreas
;
Krämer, Reinhard
)
Proteolytic degradation by FtsH proteases as regulatory mechanism of stress acclimatisation in cyanobacteria
(Project Heads
Krämer, Reinhard
;
Marin, Kay
)
Structural determinants of avian magnetoreception
(Project Head
Behrmann, Elmar
)
Structure-function analysis of Arabidopsis EDS1 immune signalling complexes
(Project Heads
Niefind, Karsten
;
Parker, Jane E.
)
Structure-function relationships of Hsp47/SERPINH1 and its role in skin fibrosis
(Project Heads
Baumann, Ulrich
;
Sengle, Gerhard
;
Zaucke, Frank
)
Synthese potentieller Inhibitoren fuer Zuckernukleosiddiphosphat-abhaengige Glykosyltransferasen
(Project Head
Legler, Günter
)
Research Units
Completed projects
Markierung von Peptidhormonen mit Metallkomplexen für Tumordiagnostik und -therapie
(Applicants
Beck-Sickinger, Annette G.
;
Neundorf, Ines
)
Mechanism of insertion of prosthetic groups into complex molybdo-enzymes (molybdo-iron-flavo enzymes)
(Applicant
Schwarz, Günter
)
Struktur-Funktions-Beziehung von Cnx1 und Gephyrin bei der Bildung von Proteinclustern in pflanzlichen und tierischen Zellen
(Applicant
Schwarz, Günter
)
Major Research Instrumentation
Completed projects
Automatisiertes Multiplex-Live-Cell-Imaging-System
Isothermes Titrationskalorimeter
Röntgendiffraktionsmessplatz
Röntgendiffraktometer für makromolekulare Kristallographie
Research Fellowships
Completed projects
Iron export failure in the neurodegenerative disease: Alzheimer´s, Parkinson´s and dementia
(Applicant
Belaidi, Ph.D., Abdel Ali
)
Structural and functional studies of repulsive guidance molecule (RGM) and its receptor neogenin
(Applicant
Gebauer, Jan
)
Research Training Groups
Current projects
GRK 2550: Dynamic regulation of cellular protein localization
(Spokesperson
Riemer, Jan
)
Completed projects
GRK 192: Scientific Computing - Computer Simulation, Optimization, Multigrid Methods, Parallel Computing
(Spokesperson
Speckenmeyer, Ewald
)
GRK 238: Mechanisms of Damage in CNS Disease - Application of Imaging Techniques
(Spokesperson
Heinemann, Uwe
)
GRK 306: Molecular Analysis of Developmental Processes
(Spokesperson
Flügge, Ulf-Ingo
)
Clusters of Excellence
Completed projects
EXC 229: Cellular Stress Responses in Aging-Associated Diseases
(Spokesperson
Brüning, Jens Claus
)
Additional Information
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